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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 11200 |
Name | CHEK2 |
Synonymous | CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1;checkpoint kinase 2;CHEK2;checkpoint kinase 2 |
Definition | CHK2 checkpoint homolog|cds1 homolog|checkpoint-like protein CHK2|protein kinase CHK2|serine/threonine-protein kinase Chk2 |
Position | 22q11|22q12.1 |
Gene Type | protein-coding |
Gene Interactions: | Physical Interaction Metabolic Interaction Signaling Interaction |
Physical Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
interacts with |
MDC1 | BIOGRID; PUBMED:12607004; |
interacts with |
CDC25A | BIOGRID; PUBMED:12759351; |
interacts with |
CDC25A | BIOGRID; PUBMED:18480045; |
interacts with |
MDM2 | BIOGRID; PUBMED:16943424; |
interacts with |
MUS81 | BIOGRID; PUBMED:11741546; |
interacts with |
CDC25C | BIOGRID; PUBMED:16705183; |
interacts with |
MSH2 | BIOGRID; PUBMED:12447371; |
interacts with |
MSH2 | BIOGRID; PUBMED:15647386; |
interacts with |
MDM4 | BIOGRID; PUBMED:16163388; |
interacts with |
TP53BP1 | BIOGRID; PUBMED:17525332; |
interacts with |
VCP | BIOGRID; PUBMED:17525332; |
interacts with |
ATM | BIOGRID; PUBMED:15064416; |
interacts with |
BRCA2 | BIOGRID; PUBMED:17525332; |
interacts with |
BRCA1 | BIOGRID; PUBMED:10724175; |
interacts with |
BRCA1 | BIOGRID; PUBMED:18804494; |
interacts with |
ATR | BIOGRID; PUBMED:17035231; |
interacts with |
REV3L | BIOGRID; PUBMED:18622427; |
interacts with |
FOXM1 | BIOGRID; PUBMED:17101782; |
interacts with |
RAD50 | BIOGRID; PUBMED:17525332; |
interacts with |
PLK1 | BIOGRID; PUBMED:12493754; |
interacts with |
GINS2 | BIOGRID; PUBMED:17525332; |
interacts with |
PLK3 | BIOGRID; PUBMED:12242661; |
interacts with |
TP53 | BIOGRID; PUBMED:12810724; |
interacts with |
MRC1 | HPRD; PUBMED:11715017; |
interacts with |
MDC1 | HPRD; PUBMED:12607004; |
interacts with |
CDC25A | HPRD; PUBMED:12676583; |
interacts with |
MDM2 | HPRD; PUBMED:15862297; |
interacts with |
MUS81 | HPRD; PUBMED:11741546; |
interacts with |
CDC25C | HPRD; PUBMED:10557092; |
interacts with |
MSH2 | HPRD; PUBMED:12447371; |
interacts with |
MSH2 | HPRD; PUBMED:15647386; |
interacts with |
MDM4 | HPRD; PUBMED:16163388; |
interacts with |
NBN | HPRD; PUBMED:11438675; |
interacts with |
ATM | HPRD; PUBMED:11901158; |
interacts with |
ATR | HPRD; PUBMED:11715017; |
interacts with |
ASF1A | HPRD; PUBMED:11172707; |
interacts with |
ERCC6 | HPRD; PUBMED:9450932; |
interacts with |
E2F1 | HPRD; PUBMED:12717439; |
interacts with |
DBF4 | HPRD; PUBMED:12441400; |
interacts with |
RAD9A | HPRD; PUBMED:12049741; |
interacts with |
PPP2R5A | HPRD; PUBMED:15380617; |
interacts with |
AATF | HPRD; PUBMED:17157788; |
interacts with |
PPP2R5E | HPRD; PUBMED:15380617; |
interacts with |
PPP2R5D | HPRD; PUBMED:15380617; |
interacts with |
PPP2R5B | HPRD; PUBMED:15380617; |
interacts with |
PPP2R2A | HPRD; PUBMED:15380617; |
interacts with |
PLK1 | HPRD; PUBMED:12493754; |
interacts with |
KPNA2 | HPRD; PUBMED:12909615; |
interacts with |
PLK3 | HPRD; PUBMED:12242661; |
interacts with |
CHEK1 | HPRD; PUBMED:15647386; |
interacts with |
CDC25A | MINT; PUBMED:11298456; |
interacts with |
MDM2 | MINT; PUBMED:15862297; |
interacts with |
NBN | MINT; PUBMED:11438675; |
interacts with |
ATM | MINT; PUBMED:21070773; |
interacts with |
RB1 | MINT; PUBMED:17380128; |
interacts with |
PER3 | MINT; PUBMED:21070773; |
interacts with |
KPNA2 | MINT; PUBMED:12909615; |
interacts with |
STRAP | MINT; PUBMED:18833288; |
interacts with |
XRCC1 | MINT; DOI:10.1038/emboj.2008.229; |
interacts with |
TP53 | MINT; PUBMED:15862297; |
interacts with |
TP53 | MINT; PUBMED:18833288; |
Metabolic Interaction | | Top | |
There is no record for CHEK2 |
Signaling Interaction | | Top | |
|
Interaction Type |
Interactor |
Data Source |
|---|---|---|
state change |
MDC1 | NCI_NATURE; PUBMED:10435585;PUBMED:10973490;PUBMED:9836640;PUBMED:10097108; |
state change |
MRE11A | NCI_NATURE; PUBMED:10435585;PUBMED:10973490;PUBMED:9836640;PUBMED:10097108; |
state change |
TP53BP1 | NCI_NATURE; PUBMED:10435585;PUBMED:10973490;PUBMED:9836640;PUBMED:10097108; |
state change |
NBN | NCI_NATURE; PUBMED:10435585;PUBMED:10973490;PUBMED:9836640;PUBMED:10097108; |
state change |
ATM | NCI_NATURE; PUBMED:10435585;PUBMED:10973490;PUBMED:9836640;PUBMED:10097108; |
state change |
BRCA1 | NCI_NATURE; PUBMED:10435585;PUBMED:10973490;PUBMED:9836640;PUBMED:10097108; |
state change |
H2AFX | NCI_NATURE; PUBMED:10435585;PUBMED:10973490;PUBMED:9836640;PUBMED:10097108; |
state change |
RNF8 | NCI_NATURE; PUBMED:10435585;PUBMED:10973490;PUBMED:9836640;PUBMED:10097108; |
state change |
RAD50 | NCI_NATURE; PUBMED:10435585;PUBMED:10973490;PUBMED:9836640;PUBMED:10097108; |
state change |
PLK3 | NCI_NATURE; PUBMED:12242661; |