|
|
||
|
|
||
| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 11200 |
Name | CHEK2 |
Synonymous | CDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1;checkpoint kinase 2;CHEK2;checkpoint kinase 2 |
Definition | CHK2 checkpoint homolog|cds1 homolog|checkpoint-like protein CHK2|protein kinase CHK2|serine/threonine-protein kinase Chk2 |
Position | 22q11|22q12.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
|
Regulation From TransFac database |
Chk2(h) + ATP --ATM(h)--> Chk2(h){pT68} + ADP (phosphorylation) | Chk2(h) + ATP --DNA-PK(h)--> ADP + Chk2(h){pT68} (phosphorylation) | Chk2(h) + STAT1(h) <==> Chk2(h):STAT1(h) (binding) | Chk2(h) + ATP --> Chk2(h){pT68} + ADP (phosphorylation) | Chk2(h) + ATP --> Chk2(h){pT387} + ADP (phosphorylation; automodification) | Chk2(h) + ATP --> Chk2(h){p} + ADP (phosphorylation) | Chk2(h) --> brca1(h):BARD1(h) (increase of binding) | Chk2(h) --> BARD1(h):Mre11(h) (increase of binding) | Chk2(h) + 5 ATP --> Chk2(h){pS120}{pS260}{pS379}{pS456}{pS516} + 5 ADP (phosphorylation) | Chk2(h) + n ubiquitin(h) --> Chk2(h){ub}n (ubiquitination) | CHEK2(h) --> Chk2(h) (expression). | Chk2(h){ub}n --Usp28(m.s.)--> Chk2(h) + ubiquitin(h) (deubiquitination) | Cdc25(h) + ATP --Chk2(h)--> Cdc25(h){p} + ADP (phosphorylation) | p53(h) + ATP --Chk2(h)--> p53(h){pS20} + ADP (phosphorylation) | p53(h) + ATP --Chk2(h)--> p53(h){pS15} + ADP (phosphorylation) | p53(h) + ATP --Chk2(h)--> p53(h){pT18} + ADP (phosphorylation) | p53(h) + ATP --Chk2(h)--> p53(h){pS37} + ADP (phosphorylation) | Cdc25A(h) + ATP --Chk2(h)--> Cdc25A(h){p} + ADP (phosphorylation) | Cdc25B(h) + ATP --Chk2(h)--> Cdc25B(h){p} + ADP (phosphorylation) | Cdc25C(h) + ATP --Chk2(h)--> Cdc25C(h){pS216} + ADP (phosphorylation) | Mdm4(h) + ATP --Chk2(h)--> Mdm4(h){pS367} + ADP (phosphorylation) | brca1(h) + ATP --Chk2(h)--> brca1(h){pS988} + ADP (phosphorylation) | Cdc25C(m.s.) + ATP --Chk2(h)--> Cdc25C(m.s.){pS216} + ADP (phosphorylation) | Cdc25C-isoform1(h) + ATP --Chk2(h)--> Cdc25C-isoform1(h){pS216} + ADP (phosphorylation) | CHEK2(h) --> Chk2-isoform1(h) (expression). | Mdm4(h) + 2 ATP --Chk2-isoform1(h)--> Mdm4(h){pS342}{pS367} + 2 ADP (phosphorylation) | brca1(h) + ATP --Chk2-isoform1(h)--> brca1(h){pS988} + ADP (phosphorylation) | CHEK2(h) --> Chk2-xbb2(h) (expression). | CHEK2(h) --> Chk2-xbb3(h) (expression). | CHEK2(h) --> Chk2-xbb4(h) (expression). | CHEK2(h) --> Chk2-xbb5(h) (expression). | CHEK2(h) --> Chk2-xbb6(h) (expression). | CHEK2(h) --> Chk2-xbb7(h) (expression). | CHEK2(h) --> Chk2-xbb8(h) (expression). | CHEK2(h) --> Chk2-xbb9(h) (expression). | CHEK2(h) --> Chk2-xbb10(h) (expression). | CHEK2(h) --> Chk2-xbb11(h) (expression). | CHEK2(h) --> Chk2-xbb12(h) (expression). |
|---|
Post Transcriptional Modification From dbPTM | | Top | |
|
Location (AA) |
PTM type |
Literature |
Database |
68 | Phosphothreonine (by MLTK). | Swiss-Prot 53.0 | 516 | Phosphoserine (CHK2) | 12805407 | Phospho.ELM 6.0 | 19 | Phosphoserine (ATM) | 10973490 | Phospho.ELM 6.0 | 28 | Phosphoserine (ATM) | 10973490 | Phospho.ELM 6.0 | 35 | Phosphoserine (ATM) | 10973490 | Phospho.ELM 6.0 | 50 | Phosphoserine (ATM) | 10973490 | Phospho.ELM 6.0 | 33 | Phosphoserine (ATM) | 10973490 | Phospho.ELM 6.0 | 68 | Phosphothreonine (ATM;CHK2;PLK) | 10973490;11901158;12493754 | Phospho.ELM 6.0 | 26 | Phosphothreonine (ATM;PLK1) | 10973490;12493754 | Phospho.ELM 6.0 | 383 | Phosphothreonine (CHK2) | 11390408 | Phospho.ELM 6.0 | 387 | Phosphothreonine (CHK2) | 11390408 | Phospho.ELM 6.0 |
|---|
Methylation Profile From DiseaseMeth database | | Top | |
|
Chromosome |
Location |
Source |
|---|---|---|
chr22 |
Promoter: 27467322 - 27469322 | GSE27584 |
chr22 |
Promoter: 27467322 - 27469322 | GSE27584 |
chr22 |
Promoter: 27467322 - 27469322 | GSE27584 |
chr22 |
Promoter: 27467322 - 27469322 | Agilent_014791_44K |
chr22 |
Promoter: 27467322 - 27469322 | Agilent_014791 |