Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

8651

Name

SOCS1

Synonymous

CIS1|CISH1|JAB|SOCS-1|SSI-1|SSI1|TIP3;suppressor of cytokine signaling 1;SOCS1;suppressor of cytokine signaling 1

Definition

JAK binding protein|JAK-binding protein|STAT induced SH3 protein 1|STAT-induced STAT inhibitor 1|TIP-3|Tec-interacting protein 3|cytokine-inducible SH2 protein 1

Position

16p13.13

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction

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Interaction Type

Interactor

Data Source

interacts with

 MAP3K5BIOGRID; PUBMED:16407264;

interacts with

 TECBIOGRID; PUBMED:9341160;

interacts with

 MPLBIOGRID; PUBMED:10517496;

interacts with

 RELABIOGRID; PUBMED:17183367;

interacts with

 NCK1BIOGRID; PUBMED:10022833;

interacts with

 KITBIOGRID; PUBMED:10022833;

interacts with

 EGFRBIOGRID; PUBMED:12070153;

interacts with

 GHRBIOGRID; PUBMED:10585430;

interacts with

 TCEB1BIOGRID; PUBMED:10051596;

interacts with

 FLT3BIOGRID; PUBMED:10022833;

interacts with

 FYNBIOGRID; PUBMED:10022833;

interacts with

 TCEB3BIOGRID; PUBMED:10051596;

interacts with

 CRKBIOGRID; PUBMED:10022833;

interacts with

 CSF1RBIOGRID; PUBMED:11297560;

interacts with

 ITKBIOGRID; PUBMED:10022833;

interacts with

 IGF1RBIOGRID; PUBMED:9727029;

interacts with

 JAK2BIOGRID; PUBMED:10064597;

interacts with

 JAK2BIOGRID; PUBMED:10455112;

interacts with

 JAK2BIOGRID; PUBMED:11713228;

interacts with

 JAK2BIOGRID; PUBMED:11971965;

interacts with

 JAK2BIOGRID; PUBMED:9202126;

interacts with

 JAK2BIOGRID; PUBMED:9344848;

interacts with

 IL2RBBIOGRID; PUBMED:11133764;

interacts with

 IRS2BIOGRID; PUBMED:12228220;

interacts with

 ALKBIOGRID; PUBMED:14968112;

interacts with

 IRS1BIOGRID; PUBMED:12228220;

interacts with

 SOCS2BIOGRID; PUBMED:17898043;

interacts with

 VAV1BIOGRID; PUBMED:10022833;

interacts with

 VAV2BIOGRID; PUBMED:10022833;

interacts with

 COMMD1BIOGRID; PUBMED:17183367;

interacts with

 Vav1CELL_MAP; PUBMED:10022833;

interacts with

 KITCELL_MAP; PUBMED:10022833;

interacts with

 EGFRCELL_MAP; PUBMED:12070153;

interacts with

 VAV2CELL_MAP; PUBMED:10022833;

interacts with

 TECHPRD; PUBMED:9341160;

interacts with

 TIRAPHPRD; PUBMED:16415872;

interacts with

 MPLHPRD; PUBMED:10517496;

interacts with

 RELAHPRD; PUBMED:14690596;

interacts with

 NCK1HPRD; PUBMED:10022833;

interacts with

 LRRC41HPRD; PUBMED:11384984;

interacts with

 KITHPRD; PUBMED:10022833;

interacts with

 TCEB2HPRD; PUBMED:10051596;

interacts with

 TCEB2HPRD; PUBMED:11384984;

interacts with

 EGFRHPRD; PUBMED:12070153;

interacts with

 GHRHPRD; PUBMED:10585430;

interacts with

 TCEB1HPRD; PUBMED:10051596;

interacts with

 TCEB1HPRD; PUBMED:11384984;

interacts with

 FLT3HPRD; PUBMED:10022833;

interacts with

 FYNHPRD; PUBMED:10022833;

interacts with

 TCEB3HPRD; PUBMED:11384984;

interacts with

 CUL5HPRD; PUBMED:11384984;

interacts with

 CSF1HPRD; PUBMED:11297560;

interacts with

 CXCR4HPRD; PUBMED:12163560;

interacts with

 ITKHPRD; PUBMED:10022833;

interacts with

 IGF1RHPRD; PUBMED:9727029;

interacts with

 JAK2HPRD; PUBMED:11971965;

interacts with

 IFNGR1HPRD; PUBMED:15522878;

interacts with

 IL2RBHPRD; PUBMED:11133764;

interacts with

 IRS2HPRD; PUBMED:12228220;

interacts with

 RBX1HPRD; PUBMED:11384984;

interacts with

 JAK1HPRD; PUBMED:11133764;

interacts with

 JAK3HPRD; PUBMED:11133764;

interacts with

 INSRHPRD; PUBMED:15169905;

interacts with

 PIM2HPRD; PUBMED:11854514;

interacts with

 PDGFRBHPRD; PUBMED:10022833;

interacts with

 IRS1HPRD; PUBMED:12228220;

interacts with

 WSB1HPRD; PUBMED:11384984;

interacts with

 VHLHPRD; PUBMED:11384984;

interacts with

 AXLHPRD; PUBMED:12470648;

interacts with

 TRIM8HPRD; PUBMED:12163497;

interacts with

 VAV1HPRD; PUBMED:10022833;

interacts with

 VAV2HPRD; PUBMED:10022833;

interacts with

 PIK3R2HPRD; PUBMED:10022833;

interacts with

 PIK3R1HPRD; PUBMED:10022833;

interacts with

 COMMD1HPRD; PUBMED:17183367;

interacts with

 MAP3K5MINT; PUBMED:16407264;

interacts with

 RELAMINT; PUBMED:17183367;

interacts with

 RELAMINT; PUBMED:19327355;

interacts with

 TUBA3CMINT; PUBMED:19327355;

interacts with

 TCEB2MINT; PUBMED:19327355;

interacts with

 TCEB1MINT; PUBMED:16643902;

interacts with

 TCEB1MINT; PUBMED:17183367;

interacts with

 TCEB1MINT; PUBMED:19327355;

interacts with

 ERBB2MINT; PUBMED:16273093;

interacts with

 CUL2MINT; PUBMED:19327355;

interacts with

 JAK2MINT; PUBMED:10421843;

interacts with

 RBX1MINT; PUBMED:19327355;

interacts with

 COMMD1MINT; PUBMED:17183367;

Metabolic Interaction

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Interaction Type

Interactor

Data Source

metabolic catalysis

 ETS1NCI_NATURE; PUBMED:15199062;PUBMED:14634100;

metabolic catalysis

 IRF1NCI_NATURE; PUBMED:10485906;PUBMED:14670297;PUBMED:17606919;

metabolic catalysis

 PIAS4NCI_NATURE; PUBMED:10485906;PUBMED:14670297;PUBMED:17606919;

metabolic catalysis

 STAT1NCI_NATURE; PUBMED:10485906;PUBMED:14670297;PUBMED:17606919;

metabolic catalysis

 STAT6NCI_NATURE; PUBMED:15199062;PUBMED:14634100;

Signaling Interaction

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Interaction Type

Interactor

Data Source

state change

 KITNCI_NATURE; PUBMED:1381360;

reacts with

 JAK2NCI_NATURE; PUBMED:10490100;PUBMED:10490099;PUBMED:11971965;

reacts with

 JAK2NCI_NATURE; PUBMED:9202126;

reacts with

 IFNGR1NCI_NATURE; PUBMED:10490100;PUBMED:10490099;PUBMED:11971965;

reacts with

 IL12BNCI_NATURE; PUBMED:9202126;

reacts with

 IFNGNCI_NATURE; PUBMED:10490100;PUBMED:10490099;PUBMED:11971965;

reacts with

 IL12RB1NCI_NATURE; PUBMED:9202126;

reacts with

 JAK1NCI_NATURE; PUBMED:10490100;PUBMED:10490099;PUBMED:11971965;

reacts with

 IL12ANCI_NATURE; PUBMED:9202126;

reacts with

 IL12RB2NCI_NATURE; PUBMED:9202126;

reacts with

 SOCS1NCI_NATURE; PUBMED:10490100;PUBMED:10490099;PUBMED:11971965;

reacts with

 SOCS1NCI_NATURE; PUBMED:1381360;

reacts with

 SOCS1NCI_NATURE; PUBMED:9202126;

reacts with

 VAV1NCI_NATURE; PUBMED:1381360;

reacts with

 TYK2NCI_NATURE; PUBMED:9202126;

state change

 KITLGNCI_NATURE; PUBMED:1381360;

reacts with

 KITREACTOME; PUBMED:15526160;PUBMED:10022833;

reacts with

 SOCS1REACTOME; PUBMED:15526160;PUBMED:10022833;

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