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| General information | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 8651 |
Name | SOCS1 |
Synonymous | CIS1|CISH1|JAB|SOCS-1|SSI-1|SSI1|TIP3;suppressor of cytokine signaling 1;SOCS1;suppressor of cytokine signaling 1 |
Definition | JAK binding protein|JAK-binding protein|STAT induced SH3 protein 1|STAT-induced STAT inhibitor 1|TIP-3|Tec-interacting protein 3|cytokine-inducible SH2 protein 1 |
Position | 16p13.13 |
Gene Type | protein-coding |
Gene Mutation: | Substitution Insertion & Deletion Other Mutation |
Substitution | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Substitution - coding silent; c.195G>A; 16:11256642-11256642 |
haematopoietic_and_lymphoid_ti; lymph_node | diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Substitution - coding silent; c.99C>T; 16:11256738-11256738 |
y; lung | small_cell_carcinoma; carcinoma |
Substitution - coding silent; c.528G>A; 16:11256309-11256309 |
haematopoietic_and_lymphoid_ti; lymph_node | diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Substitution - coding silent; c.345T>G; 16:11256492-11256492 |
haematopoietic_and_lymphoid_ti; lymph_node | diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Substitution - coding silent; c.99C>T; 16:11256738-11256738 |
y; lung | small_cell_carcinoma; carcinoma |
Substitution - coding silent; c.621C>T; 16:11256216-11256216 |
haematopoietic_and_lymphoid_ti; lymph_node | diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Indel | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Deletion - In frame; c.393_407del15; 16:11256430-11256444 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.349_359del11; 16:11256478-11256488 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.208_257del50; 16:11256580-11256629 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - In frame; c.552_575del24; 16:11256262-11256285 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.526_533delGAGCTGTG; 16:11256304-11256311 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.150_166del17; 16:11256671-11256687 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.483_489delGCTGGGG; 16:11256348-11256354 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - In frame; c.388_402del15; 16:11256435-11256449 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.454_464del11; 16:11256373-11256383 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - In frame; c.186_323del138; 16:11256514-11256651 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.108_171del64; 16:11256666-11256729 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.495_502delGCTGCGCC; 16:11256335-11256342 |
haematopoietic_and_lymphoid_ti; lymph_node | diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.431_512del82; 16:11256325-11256406 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.191_218del28; 16:11256619-11256646 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.349_359del11; 16:11256478-11256488 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - In frame; c.471_482del12; 16:11256355-11256366 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.216_225del10; 16:11256612-11256621 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.190_200del11; 16:11256637-11256647 |
haematopoietic_and_lymphoid_ti; lymph_node | diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.454_464del11; 16:11256373-11256383 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.108_171del64; 16:11256666-11256729 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - In frame; c.552_575del24; 16:11256262-11256285 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.526_533delGAGCTGTG; 16:11256304-11256311 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.145_149delGCCCC; 16:11256688-11256692 |
haematopoietic_and_lymphoid_ti | primary; myelofibrosis; haematopoietic_neoplasm |
Deletion - Frameshift; c.526_533delGAGCTGTG; 16:11256304-11256311 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - In frame; c.511_537del27; 16:11256300-11256326 |
haematopoietic_and_lymphoid_ti; lymph_node | diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.490delG; 16:11256347-11256347 |
haematopoietic_and_lymphoid_ti | acute_lymphoblastic_T_cell_leukaemia; lymphoid_neoplasm |
Deletion - Frameshift; c.343_349delCTTAGCG; 16:11256488-11256494 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.193_203del11; 16:11256634-11256644 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Deletion - In frame; c.318_377del60; 16:11256460-11256519 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.192_541del350; 16:11256296-11256645 |
haematopoietic_and_lymphoid_ti; mediastinum | primary_mediastinal_B_cell_lymphoma; diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - In frame; c.379_636del258; 16:11256201-11256458 |
haematopoietic_and_lymphoid_ti; lymph_node | diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Deletion - Frameshift; c.177_195del19; 16:11256642-11256660 |
haematopoietic_and_lymphoid_ti; lymph_node | diffuse_large_B_cell_lymphoma; lymphoid_neoplasm |
Other Mutation | | Top | |
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
Complex - deletion inframe; c.435_448>GG; 16:11256389-11256402 |
haematopoietic_and_lymphoid_ti; lymph_node | Hodgkin_lymphoma; lymphoid_neoplasm |
Whole gene deletion; c.1_636del636; 16:11014208-11349113 |
haematopoietic_and_lymphoid_ti; skin | mycosis_fungoides-Sezary_syndrome; lymphoid_neoplasm |
Complex - deletion inframe; c.353_367del15; 16:11256470-11256484 |
haematopoietic_and_lymphoid_ti; lymph_node | follicular_lymphoma; lymphoid_neoplasm |