Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

9021

Name

SOCS3

Synonymous

ATOD4|CIS3|Cish3|SOCS-3|SSI-3|SSI3;suppressor of cytokine signaling 3;SOCS3;suppressor of cytokine signaling 3

Definition

CIS-3|STAT-induced STAT inhibitor 3|cytokine-induced SH2 protein 3|cytokine-inducible SH2 protein 3

Position

17q25.3

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction

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Interaction Type

Interactor

Data Source

interacts with

 MAP3K5BIOGRID; PUBMED:16407264;

interacts with

 MAP3K7BIOGRID; PUBMED:16543409;

interacts with

 TRAF6BIOGRID; PUBMED:16543409;

interacts with

 NONOBIOGRID; PUBMED:18952062;

interacts with

 LEPRBIOGRID; PUBMED:11018044;

interacts with

 LEPRBIOGRID; PUBMED:21239736;

interacts with

 EGFRBIOGRID; PUBMED:12070153;

interacts with

 GHRBIOGRID; PUBMED:10585430;

interacts with

 PTK2BBIOGRID; PUBMED:9344848;

interacts with

 EPORBIOGRID; PUBMED:10882725;

interacts with

 EPORBIOGRID; PUBMED:12027890;

interacts with

 CXCR4BIOGRID; PUBMED:12163560;

interacts with

 CSF1RBIOGRID; PUBMED:12133942;

interacts with

 IGF1RBIOGRID; PUBMED:11071852;

interacts with

 JAK2BIOGRID; PUBMED:10421843;

interacts with

 JAK2BIOGRID; PUBMED:10882725;

interacts with

 JAK2BIOGRID; PUBMED:9344848;

interacts with

 IL6STBIOGRID; PUBMED:12403768;

interacts with

 RASA1BIOGRID; PUBMED:11331873;

interacts with

 INSRBIOGRID; PUBMED:12560330;

interacts with

 PRLRBIOGRID; PUBMED:11713228;

interacts with

 PTPN11BIOGRID; PUBMED:12403768;

interacts with

 PIN1BIOGRID; PUBMED:16169070;

interacts with

 EGFRCELL_MAP; PUBMED:12070153;

interacts with

 RASA1CELL_MAP; PUBMED:11331873;

interacts with

 LEPRHPRD; PUBMED:11018044;

interacts with

 BCL10HPRD; PUBMED:15213237;

interacts with

 TCEB2HPRD; PUBMED:10051596;

interacts with

 EGFRHPRD; PUBMED:12070153;

interacts with

 GHRHPRD; PUBMED:10585430;

interacts with

 TCEB1HPRD; PUBMED:10051596;

interacts with

 EPORHPRD; PUBMED:12027890;

interacts with

 CSF3RHPRD; PUBMED:12133942;

interacts with

 CXCR4HPRD; PUBMED:12163560;

interacts with

 IGF1RHPRD; PUBMED:11071852;

interacts with

 JAK2HPRD; PUBMED:9344848;

interacts with

 IL2RBHPRD; PUBMED:10373548;

interacts with

 IL6STHPRD; PUBMED:12403768;

interacts with

 IRS2HPRD; PUBMED:15514089;

interacts with

 CSNK1EHPRD; PUBMED:15070676;

interacts with

 RASA1HPRD; PUBMED:11331873;

interacts with

 JAK1HPRD; PUBMED:10707961;

interacts with

 JAK3HPRD; PUBMED:10373548;

interacts with

 INSRHPRD; PUBMED:12560330;

interacts with

 PRLRHPRD; PUBMED:11713228;

interacts with

 PPP3CBHPRD; PUBMED:11970967;

interacts with

 PTPN11HPRD; PUBMED:12403768;

interacts with

 PIN1HPRD; PUBMED:16169070;

interacts with

 IRS1HPRD; PUBMED:12228220;

interacts with

 SOCS2HPRD; PUBMED:16199887;

interacts with

 MAP1SMINT; PUBMED:19027008;

interacts with

 EPORMINT; PUBMED:10882725;

interacts with

 JAK2MINT; PUBMED:10421843;

interacts with

 RASA1MINT; PUBMED:11331873;

interacts with

 IL12RB2MINT; PUBMED:14559241;

interacts with

 PIN1MINT; PUBMED:16169070;

Metabolic Interaction

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Interaction Type

Interactor

Data Source

metabolic catalysis

 MAPK14NCI_NATURE; PUBMED:15728454;

metabolic catalysis

 LCKNCI_NATURE; PUBMED:10373548;

metabolic catalysis

 LEPRNCI_NATURE; PUBMED:10514492;

metabolic catalysis

 ATF2NCI_NATURE; PUBMED:19422799;

metabolic catalysis

 IL2RANCI_NATURE; PUBMED:10373548;

metabolic catalysis

 JAK2NCI_NATURE; PUBMED:10514492;

metabolic catalysis

 IL2RBNCI_NATURE; PUBMED:10373548;

metabolic catalysis

 IL2RGNCI_NATURE; PUBMED:10373548;

metabolic catalysis

 JAK1NCI_NATURE; PUBMED:10373548;

metabolic catalysis

 JAK3NCI_NATURE; PUBMED:10373548;

metabolic catalysis

 IL2NCI_NATURE; PUBMED:10373548;

metabolic catalysis

 STAT3NCI_NATURE; PUBMED:10514492;

Signaling Interaction

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Interaction Type

Interactor

Data Source

reacts with

 LCKNCI_NATURE; PUBMED:16199887;

state change

 LCKNCI_NATURE; PUBMED:10373548;PUBMED:11331873;

reacts with

 EPONCI_NATURE; PUBMED:10882725;

reacts with

 EPONCI_NATURE; PUBMED:15705783;PUBMED:7889566;PUBMED:8343951;

reacts with

 EPORNCI_NATURE; PUBMED:10882725;

reacts with

 EPORNCI_NATURE; PUBMED:15705783;PUBMED:7889566;PUBMED:8343951;

state change

 IL2RANCI_NATURE; PUBMED:10373548;PUBMED:11331873;

reacts with

 JAK2NCI_NATURE; PUBMED:15705783;PUBMED:7889566;PUBMED:8343951;

reacts with

 JAK2NCI_NATURE; PUBMED:16698929;

reacts with

 IL2RBNCI_NATURE; PUBMED:16199887;

state change

 IL2RBNCI_NATURE; PUBMED:10373548;PUBMED:11331873;

reacts with

 IL6STNCI_NATURE; PUBMED:10777583;

reacts with

 IL12BNCI_NATURE; PUBMED:16698929;

state change

 IL2RGNCI_NATURE; PUBMED:10373548;PUBMED:11331873;

reacts with

 IL12RB1NCI_NATURE; PUBMED:16698929;

reacts with

 RASA1NCI_NATURE; PUBMED:11331873;

reacts with

 JAK1NCI_NATURE; PUBMED:10777583;

reacts with

 JAK1NCI_NATURE; PUBMED:16199887;

state change

 JAK1NCI_NATURE; PUBMED:10373548;PUBMED:11331873;

state change

 JAK3NCI_NATURE; PUBMED:10373548;PUBMED:11331873;

reacts with

 IL6RNCI_NATURE; PUBMED:10777583;

state change

 IL2NCI_NATURE; PUBMED:10373548;PUBMED:11331873;

state change

 PTPN6NCI_NATURE; PUBMED:15705783;PUBMED:7889566;PUBMED:8343951;

reacts with

 IL23ANCI_NATURE; PUBMED:16698929;

reacts with

 IL6NCI_NATURE; PUBMED:10777583;

reacts with

 IL23RNCI_NATURE; PUBMED:16698929;

reacts with

 SOCS3NCI_NATURE; PUBMED:10777583;

reacts with

 SOCS3NCI_NATURE; PUBMED:10882725;

reacts with

 SOCS3NCI_NATURE; PUBMED:11331873;

reacts with

 SOCS3NCI_NATURE; PUBMED:15705783;PUBMED:7889566;PUBMED:8343951;

reacts with

 SOCS3NCI_NATURE; PUBMED:16199887;

reacts with

 SOCS3NCI_NATURE; PUBMED:16698929;

reacts with

 SOCS2NCI_NATURE; PUBMED:16199887;

reacts with

 TYK2NCI_NATURE; PUBMED:16698929;

state change

 SH2B3NCI_NATURE; PUBMED:15705783;PUBMED:7889566;PUBMED:8343951;

reacts with

 SOCS3REACTOME; PUBMED:12754505;PUBMED:9419338;PUBMED:9789053;PUBMED:10064597;PUBMED:12403768;PUBMED:11527983;PUBMED:10777583;PUBMED:9889194;

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