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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 9021 |
Name | SOCS3 |
Synonymous | ATOD4|CIS3|Cish3|SOCS-3|SSI-3|SSI3;suppressor of cytokine signaling 3;SOCS3;suppressor of cytokine signaling 3 |
Definition | CIS-3|STAT-induced STAT inhibitor 3|cytokine-induced SH2 protein 3|cytokine-inducible SH2 protein 3 |
Position | 17q25.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
Jak1(m){pY} + SOCS-3(h) <==> Jak1(m){pY}:SOCS-3(h) (binding) | IL-2Rbeta(h){pY}:Jak1(h){pY} + SOCS-3(h) <==> IL-2Rbeta(h){pY}:Jak1(h){pY}:SOCS-3(h) (binding) | EpoR(h){pY401} + SOCS-3(h) <==> EpoR(h){pY401}:SOCS-3(h) (binding) | EpoR(h){pY429}{pY431} + SOCS-3(h) <==> EpoR(h){pY429}{pY431}:SOCS-3(h) (binding) | SOCS-3(h) + Jak2(m) <==> SOCS-3(h):Jak2(m) (binding) | SOCS-3(h) + EpoR(m){pY401} <==> SOCS-3(h):EpoR(m){pY401} (binding) | SOCS-3(h) + bcl10(h) <==> SOCS-3(h):bcl10(h) (binding) | SOCS-3(h) + Jak3(h) <==> SOCS-3(h):Jak3(h) (binding) | SOCS-3(h) --/ IFNgamma(h) (decrease of abundance) | lepr-B(m){pY985} + SOCS-3(h) <==> lepr-B(m){pY985}:SOCS-3(h) (binding) | SOCS-3(h) + Pin1(h) <==> SOCS-3(h):Pin1(h) (binding) | SOCS3(h) --> SOCS-3(h) (expression). | IL-2(m.s.) --> SOCS-3(h) (increase of abundance) | prolactin(h) --/ SOCS-3(h) (decrease of abundance) | IFNgamma(m.s.) --> SOCS-3(h) (increase of abundance) | IGF-1R(m.s.) + SOCS-3(h) <==> IGF-1R(m.s.):SOCS-3(h) (binding) | SOCS-3(h) + IGF-1R(h){pY} <==> SOCS-3(h):IGF-1R(h){pY} (binding) | SOCS-3(h) + ATP --> SOCS-3(h){pY} + ADP (phosphorylation) | SOCS-3(h) + InsR(m.s.) <==> SOCS-3(h):InsR(m.s.) (binding) | SOCS-3(h) + IGF-1R(m.s.){pY} <==> SOCS-3(h):IGF-1R(m.s.){pY} (binding) | IL-12Rbeta2(h){pY800} + SOCS-3(h) <==> IL-12Rbeta2(h){pY800}:SOCS-3(h) (binding) | SOCS-3(h) --> STAT5B(m){pY} (decrease of phosphorylation) | SOCS-3(h) --> STAT3(m){p} (decrease of phosphorylation) | SOCS-3(h) + SOCS-2(m.s.) <==> SOCS-3(h):SOCS-2(m.s.) (binding) | SOCS-3(h) --> STAT3(h){pY705} (decrease of phosphorylation) | SOCS-3(h) + FAK1(h){pY397} <==> SOCS-3(h):FAK1(h){pY397} (binding) | SOCS-3(h) + n ubiquitin(h) --> SOCS-3(h){ub(n)} (ubiquitination) | elongin B(h) + SOCS-3(h) <==> elongin B(h):SOCS-3(h) (binding) | ErbB2(h){pY1222} + SOCS-3(h) <==> ErbB2(h){pY1222}:SOCS-3(h) (binding) | SHP-2(mo) + SOCS-3(h) <==> SHP-2(mo):SOCS-3(h) (binding) | SOCS-3(h) --> rhodopsin(m) (increase of abundance) | SOCS-3(h) --> STAT3(m){pY705} (decrease of phosphorylation) | SOCS-3(h) + ASK1(m.s.) <==> SOCS-3(h):ASK1(m.s.) (binding) | SOCS3(h) --> SOCS-3(h) (expression). | elongin B(m.s.) --/ SOCS-3(h) (decrease of abundance) | elongin C(m.s.) --/ SOCS-3(h) (decrease of abundance) | LPS --> SOCS-3(h) (increase of abundance) |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
204 | Phosphotyrosine (JAK2) | 12783885 | Phospho.ELM 6.0 | 221 | Phosphotyrosine (JAK2) | 12783885;15173187 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr17 |
Promoter: 73867253 - 73869253 | Agilent_014791 |
chr17 |
Promoter: 73867253 - 73869253 | GSE27584 |
chr17 |
Promoter: 73867253 - 73869253 | Agilent_014791_44K |
chr17 |
Promoter: 73867253 - 73869253 | PMID:16007195 |
chr17 |
Promoter: 73867253 - 73869253 | PMID:17241887 |
chr17 |
Promoter: 73867253 - 73869253 | PMID:17376806 |
chr17 |
Promoter: 73867253 - 73869253 | PMID:16644104 |
chr17 |
Promoter: 73867253 - 73869253 | PMID:16007169 |