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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 150094 |
Name | SIK1 |
Synonymous | MSK|SIK|SNF1LK;salt-inducible kinase 1;SIK1;salt-inducible kinase 1 |
Definition | SIK-1|SNF1-like kinase|myocardial SNF1-like kinase|salt-inducible protein kinase 1|serine/threonine protein kinase|serine/threonine-protein kinase SIK1|serine/threonine-protein kinase SNF1-like kinase 1|serine/threonine-protein kinase SNF1LK |
Position | 21q22.3 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
SIK(h) + ATP --LKB1(m):STRADalpha(h):MO25(h)--> SIK(h){pT182} + ADP (phosphorylation) | SIK(h) + ATP --LKB1(m):STRADalpha(h):MO25beta(h)--> SIK(h){pT182} + ADP (phosphorylation) | SIK(h) + ATP --LKB1(m):STRADbeta(h):MO25(h)--> SIK(h){pT182} + ADP (phosphorylation) | SIK(h) + ATP --LKB1(m.s.)--> SIK(h){pT182} + ADP (phosphorylation) | SIK(h) + ATP --LKB1(m.s.):STRADbeta(m.s.):MO25(m.s.)--> SIK(h){pT182} + ADP (phosphorylation) | SIK(h) + 14-3-3zeta(h) <==> SIK(h):14-3-3zeta(h) (binding) | Snf1lk(h) --> SIK(h) (expression). | SIK(h) + 14-3-3zeta(h) <==> SIK(h):14-3-3zeta(h) (binding) | 14-3-3epsilon(h) + 14-3-3zeta(h) + alpha-tubulin 1B(h) + Hsp70-1(h) + SIK(h) <==> 14-3-3epsilon(h):14-3-3zeta(h):alpha-tubulin 1B(h):Hsp70-1(h):SIK(h) (binding) | Snf1lk(h) --> SIK(h) (expression). | TORC2(h) + ATP --SIK(h)--> TORC2(h){pS70}{pS171}{pS348} + ADP (phosphorylation) |
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Post Transcriptional Modification From dbPTM | | Top | |
There is no record for SIK1 |
Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
|---|---|---|
chr21 |
Promoter: 43670930 - 43672930 | GSE27584 |
chr21 |
Promoter: 43670930 - 43672930 | Agilent_014791_44K |