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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 1958 |
Name | EGR1 |
Synonymous | AT225|G0S30|KROX-24|NGFI-A|TIS8|ZIF-268|ZNF225;early growth response 1;EGR1;early growth response 1 |
Definition | EGR-1|early growth response protein 1|nerve growth factor-induced protein A|transcription factor ETR103|transcription factor Zif268|zinc finger protein 225|zinc finger protein Krox-24 |
Position | 5q31.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
Egr-1(h) --> IL3(h) (DNA binding). | Egr-1(h) --> FOSL1(h) (DNA binding; transactivation). | Egr-1(h) --> TNF(h) (DNA binding; transactivation). | Egr-1(h) --> FASLG(h) (DNA binding; transactivation). | Egr-1(h) --> MAOB(h) (DNA binding; transactivation). | Egr-1(h) --> RET(h) (DNA binding; transregulation). | Egr-1(h) --> COL1A2(h) (DNA binding). | Egr-1(h) + AR-isoform1(h) <==> Egr-1(h):AR-isoform1(h) (binding) | Egr-1(h) + AR(h) <==> Egr-1(h):AR(h) (binding) | Egr-1(h) --> KLK3(h) (transactivation) | Egr-1(h) + NF-AT2(m.s.) <==> Egr-1(h):NF-AT2(m.s.) (binding) | Egr-1(h) + NF-AT1(m.s.) <==> Egr-1(h):NF-AT1(m.s.) (binding) | Egr-1(h) --> COL2A1(h) (DNA binding). | Egr-1(h) --> F3(h) (DNA binding; transactivation). | Egr-1(h) --/ ABCA2(h) (DNA binding; transrepression). | Egr-1(h) --> PTGES(h) (DNA binding). | Egr-1(h) --> ACE(h) (DNA binding). | Egr-1(h) --> SOD1(h) (DNA binding; transactivation). | Egr-1(h) --> NDRG1(h) (DNA binding). | Egr-1(h) --> CCR5(h) (DNA binding). | Egr-1(h) --> GADD45A(h) (DNA binding). | Egr-1(h) + Sp1(h) <==> Egr-1(h):Sp1(h) (binding) | Egr-1(h) --> Egr1(m) (DNA binding). | Egr-1(h) --> IL2RB(h) (DNA binding). | Egr-1(h) --> NFKB1(h) (DNA binding; transactivation). | Egr-1(h) --> CCND1(h) (DNA binding). | Egr-1(h) --> FGF2(h) (DNA binding). | Egr-1(h) --> PPARG(h) (DNA binding; transactivation). | Egr-1(h) --> FLT1(h) (DNA binding). | Egr-1(h) --> ID1(h) (DNA binding). | Egr-1(h) --> CAT(h) (DNA binding). | Egr-1(h) --> PTP4A1(h) (DNA binding). | Egr-1(h) --> NAB2(h) (DNA binding). | Egr-1(h) --> SLC9A3(h) (DNA binding). | Egr-1(h) --> SLC9A2(h) (DNA binding). | Egr-1(h) --> LDLR(h) (DNA binding). | Egr-1(h) --> IL2RB(m) (DNA binding). | Egr-1(h) --> Chga(m) (DNA binding; transactivation). | Egr-1(h) --> HPSE(h) (transactivation) | Egr-1(h) --> PDGFA(h) (DNA binding). | Egr-1(h) --> BIRC5(h) (DNA binding). | Egr-1(h) --> CD44(h) (DNA binding). | Egr-1(h) --> ATF3(h) (DNA binding). | Egr-1(h) --> ID2(h) (DNA binding). | Egr-1(h) --> c-myb(h) (DNA binding). | Egr-1(h) --> ACTA2(h) (DNA binding). | Egr-1(h) --> FN1(h) (DNA binding). | Egr-1(h) --> TBXA2R(h) (DNA binding). | Egr-1(h) --> GNAQ(h) (DNA binding). | Egr-1(h) --> PTPRZ1(h) (DNA binding; transactivation). | Egr-1(h) --> GDF15(h) (DNA binding). | Egr-1(h) --> FYN(h) (transactivation) | Egr-1(h) --> IGF2(h) (DNA binding). | Egr-1(h) --> HIF1A(h) (DNA binding). | Egr-1(h) --> PRDM1(h) (DNA binding). | Egr-1(h) --> SRD5A1(h) (DNA binding). | EGR1(h) --> Egr-1(h) (expression). | (PDGFB(h))2 --> Egr-1(h) (increase of abundance) | Egr-1(h) --> IL2(h) (DNA binding; transactivation). | Egr-1(h) --> ELK1(h) (DNA binding; transactivation). | Egr-1(h) --> EGFR(h) (DNA binding; transregulation). | Egr-1(h) --/ TGFBR2(h) (DNA binding; transrepression). | Egr-1(h) --/ c-Met(m) (decrease of abundance) | Egr-1(h) --/ c-Met(h) (decrease of abundance) | Egr-1(h) --/ MET(h) (transrepression) | Egr-1(h) + RelA-p65(h) <==> Egr-1(h):RelA-p65(h) (binding) | Egr-1(h) --> TNF(h) (transactivation) | NF-AT2(m.s.) + Egr-1(h) <==> NF-AT2(m.s.):Egr-1(h) (binding) | NF-AT1(m.s.) + Egr-1(h) <==> NF-AT1(m.s.):Egr-1(h) (binding) | Egr-1(h) --/ ADRB1(r) (DNA binding; transrepression). | Egr-1(h) --> SREBF1(h) (DNA binding). | Egr-1(h) --> PDGFC(h) (DNA binding). | Egr-1(h) --> Chga(m) (transactivation) | Egr-1(h) --> ATF3(h) (transactivation) | EGR1(h) --> Egr-1(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr5 |
Promoter: 137827580 - 137829580 | Agilent_014791 |
chr5 |
Promoter: 137827580 - 137829580 | GSE27584 |