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| General information | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 4089 |
Name | SMAD4 |
Synonymous | DPC4|JIP|MADH4;SMAD family member 4;SMAD4;SMAD family member 4 |
Definition | MAD homolog 4|SMAD, mothers against DPP homolog 4|deleted in pancreatic carcinoma locus 4|deletion target in pancreatic carcinoma 4|mothers against decapentaplegic homolog 4|mothers against decapentaplegic, Drosophila, homolog of, 4 |
Position | 18q21.1 |
Gene Type | protein-coding |
Gene Regulation: | Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Transcription Factors | | Top | |
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Regulation From TransFac database |
Smad2-L(h) + smad4(h) --TGFbetaR-I(h)--> Smad2-L(h):smad4(h) (binding) | smad4(h) + importin-beta(h) <==> smad4(h):importin-beta(h) (binding) | Smad2-L(h) + smad4(h) --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad2-L(h):smad4(h) (binding) | Smad3(h) + smad4(h) --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad3(h):smad4(h) (binding) | Smad8(r) + smad4(h) --ActR-I(x)--> Smad8(r):smad4(h) (binding) | Smad3(h) + smad4(h) --TGFbetaR-I(h)--> Smad3(h):smad4(h) (binding) | smad4(h) + Smad6(h) <==> smad4(h):Smad6(h) (binding) | Smad1(h) + smad4(h) <==> Smad1(h):smad4(h) (binding) | Smad2-L(h){p} + smad4(h) <==> Smad2-L(h){p}:smad4(h) (binding) | smad4(h) --> Mix.2(x) (DNA binding). | smad4(h) --> MMP1(h) (DNA binding). | smad4(h) --> JUN(h) (DNA binding). | smad4(h) --> SERPINE1(h) (DNA binding). | smad4(h) --> Junb(m) (DNA binding). | smad4(h) --> vent-2(x) (DNA binding). | p62Dok-1(m) + smad4(h) <==> p62Dok-1(m):smad4(h) (binding) | beta-catenin(h) + smad4(h) <==> beta-catenin(h):smad4(h) (binding) | LEF-1(m) + smad4(h) <==> LEF-1(m):smad4(h) (binding) | Smad3(h) + smad4(h) <==> Smad3(h):smad4(h) (binding) | smad4(h) --> twin(x) (DNA binding; transactivation). | HNF-4alpha(h) + smad4(h) <==> HNF-4alpha(h):smad4(h) (binding). | HNF-4alpha(r) + smad4(h) <==> HNF-4alpha(r):smad4(h) (binding). | smad4(h) + Smad2(h) <==> smad4(h):Smad2(h) (binding) | smad4(h) + CRI2(h) <==> smad4(h):CRI2(h) (binding) | smad4(h) + FOXO1A(h) <==> smad4(h):FOXO1A(h) (binding) | FOXO3a(h) + smad4(h) <==> FOXO3a(h):smad4(h) (binding) | smad4(h) + foxo4(h) <==> smad4(h):foxo4(h) (binding) | Smad2-L(h) + smad4(h) <==> Smad2-L(h):smad4(h) (binding) | EIF4ENIF1(m.s.) + smad4(h) <==> EIF4ENIF1(m.s.):smad4(h) (binding) | ZNF198(m.s.) + smad4(h) <==> ZNF198(m.s.):smad4(h) (binding) | PEX6(m.s.) + smad4(h) <==> PEX6(m.s.):smad4(h) (binding) | SF3B2(m.s.) + smad4(h) <==> SF3B2(m.s.):smad4(h) (binding) | smad4(h) + p68(m) <==> smad4(h):p68(m) (binding) | smad4(h) + Erbin(m.s.) <==> smad4(h):Erbin(m.s.) (binding) | Dvl-1(m.s.) + smad4(h) <==> Dvl-1(m.s.):smad4(h) (binding) | smad4(h) + Par3(m.s.) <==> smad4(h):Par3(m.s.) (binding) | smad4(h) + col1a2(m.s.) <==> smad4(h):col1a2(m.s.) (binding) | COL3A1(m.s.) + smad4(h) <==> COL3A1(m.s.):smad4(h) (binding) | COL5A2(m.s.) + smad4(h) <==> COL5A2(m.s.):smad4(h) (binding) | smad4(h) + Smad1(h) + RbAp48(h) + RbAp46(h) + sin3a(h) + HDAC1(h) + Nkx3-2(c) <==> smad4(h):Smad1(h):RbAp48(h):RbAp46(h):sin3a(h):HDAC1(h):Nkx3-2(c) (binding) | Daxx(h) + smad4(h) <==> Daxx(h):smad4(h) (binding) | Ubc9(h) + smad4(h) <==> Ubc9(h):smad4(h) (binding) | Daxx(h) + smad4(h) <==> Daxx(h):smad4(h) (binding) | smad4(h) + ATP --PDK1(h)--> smad4(h){p} + ADP (phosphorylation) | smad4(h) --> TGFB2(h) (DNA binding). | smad4(h) --> SERPINB5(h) (DNA binding). | smad4(h) --> Gast(m) (DNA binding; transactivation). | smad4(h) --> ELN(h) (DNA binding). | EWS(h) + smad4(h) <==> EWS(h):smad4(h) (binding) | smad4(h) + Smad8(h) <==> smad4(h):Smad8(h) (binding) | smad4(h) --> SMAD7(h) (DNA binding). | smad4(h) --> Il10(m) (DNA binding). | smad4(h) --> MMP13(h) (DNA binding). | smad4(h) --/ SEPP1(h) (DNA binding; transrepression). | smad4(h) --> c-myc(h) (DNA binding). | c-Ski(h) + Smad2(h) + Smad4(h) <==> c-Ski(h):Smad2(h):Smad4(h) (binding) | Smad4(h) --/ Pax-3(h) (decrease of abundance) | Smad4(h) --> PDGFB(h) (DNA binding). | SMAD4(h) --> smad4(h) (expression). | SMAD4(h) --> smad4delta3(h) (expression). | SMAD4(h) --> smad4delta4(h) (expression). | SMAD4(h) --> smad4delta6(h) (expression). | SMAD4(h) --> smad4delta5-6(h) (expression). | SMAD4(h) --> smad4delta4-6(h) (expression). | SMAD4(h) --> smad4delta4-7(h) (expression). | TCF-4(h) + Smad4(h) <==> TCF-4(h):Smad4(h) (binding) | Smad4(h) --> Skil(m) (DNA binding). | Smad4(h) --> Gnrhr(m) (DNA binding). | SMAD4(h) --> Smad4(h) (expression). |
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Post Transcriptional Modification From dbPTM | | Top | |
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Location (AA) |
PTM type |
Literature |
Database |
277 | Phosphothreonine (MAP2K2) | 12801888 | Phospho.ELM 6.0 |
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Methylation Profile From DiseaseMeth database | | Top | |
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Chromosome |
Location |
Source |
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chr18 |
Promoter: 46809111 - 46811111 | Agilent_014791 |
chr18 |
Promoter: 46809111 - 46811111 | GoldenGate_Methylation_Cancer_Panel_I |
chr18 |
Promoter: 46809111 - 46811111 | GSE27584 |
chr18 |
Promoter: 46809111 - 46811111 | Agilent_014791 |