Bioinformatics and Systems Medicine Laboratory
General information | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

857

Name

CAV1

Synonymous

BSCL3|CGL3|MSTP085|VIP21;caveolin 1, caveolae protein, 22kDa;CAV1;caveolin 1, caveolae protein, 22kDa

Definition

caveolin-1|cell growth-inhibiting protein 32

Position

7q31.1

Gene Type

protein-coding

Gene Regulation:

Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Transcription Factors

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Regulation From TransFac database

caveolin-1(h) + uPAR(m.s.):beta1-integrin(h) <==> uPAR(m.s.):beta1-integrin(h):caveolin-1(h) (binding)
caveolin-1(h) + beta1-integrin(h) <==> caveolin-1(h):beta1-integrin(h) (binding)
H-Ras(h) + caveolin-1(h) <==> H-Ras(h):caveolin-1(h) (binding)
caveolin-1(h) --> caveolin-1(h) (translocation)
caveolin-1(h) --> FAK1(h){p} (increase of phosphorylation)
Cdc42(h) + caveolin-1(h) <==> Cdc42(h):caveolin-1(h) (binding)
Rac1(h) + caveolin-1(h) <==> Rac1(h):caveolin-1(h) (binding)
caveolin-1(h) --> Cdc42(h) (regulation of protein activity)
caveolin-1(h) --> AKT-1(h){pS473} (increase of phosphorylation)
5alphaDHT:AR(h) + caveolin-1(h) <==> 5alphaDHT:AR(h):caveolin-1(h) (regulation of localization; binding)
SHP-1(h) + caveolin-1(h) <==> SHP-1(h):caveolin-1(h) (binding)
caveolin-1(h) + STAT3(h) <==> caveolin-1(h):STAT3(h) (binding)
Hsp90(h) + caveolin-1(h) + STAT3(h) <==> Hsp90(h):caveolin-1(h):STAT3(h) (binding)
caveolin-1(h) + STAT3(h){pY} <==> caveolin-1(h):STAT3(h){pY} (binding)
GRP58(h) + Hsp90(h) + STAT1(h) + caveolin-1(h) + STAT3(h) <==> GRP58(h):Hsp90(h):STAT1(h):caveolin-1(h):STAT3(h) (binding)
ErbB1(h) + caveolin-1(h) <==> ErbB1(h):caveolin-1(h) (binding)
caveolin-1(h) + ErbB2(h) <==> caveolin-1(h):ErbB2(h) (binding)
caveolin-1(h) + ErbB1(h){pY} <==> caveolin-1(h):ErbB1(h){pY} (binding)
PKCepsilon(m) + caveolin-1(h) <==> PKCepsilon(m):caveolin-1(h) (binding)
ER-beta(h){pal} + caveolin-1(h) <==> ER-beta(h){pal}:caveolin-1(h) (binding)
ER-alpha-L(h){palC447} + caveolin-1(h) <==> ER-alpha-L(h){palC447}:caveolin-1(h) (binding)
caveolin-1(h) + ATP --> caveolin-1(h){pY14} + ADP (phosphorylation)
caveolin-1(h) + Rock-1(h) <==> caveolin-1(h):Rock-1(h) (binding)
caveolin-1(h) + atp1a1(r) <==> caveolin-1(h):atp1a1(r) (binding)
caveolin-1(h) + nostrin(m.s.) <==> caveolin-1(h):nostrin(m.s.) (binding)
caveolin-1(h) + eNOS(h) + nostrin(h) <==> caveolin-1(h):eNOS(h):nostrin(h) (binding)
endoglin(h) + Hsp90(h) + caveolin-1(h) + eNOS(h) <==> endoglin(h):Hsp90(h):caveolin-1(h):eNOS(h) (binding)
caveolin-1(h) + ptrf(h) + SDR(h) <==> caveolin-1(h):ptrf(h):SDR(h) (binding)
CAV1(h) --> caveolin-1(h) (expression).
LDL(h) --> caveolin-1(h) (increase of abundance)
caveolin-1(h) --> caveolin-1(h) (translocation)
TRAF2(h) --> caveolin-1(h) (binding)
H2O2 --> caveolin-1(h) (increase of abundance)
slc7a11(h) --/ caveolin-1(h) (decrease of abundance)
CAV1(h) --> caveolin-1alpha(h) (expression).
CAV1(h) --> caveolin-1beta(h) (expression).

Post Transcriptional Modification From dbPTM

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Location (AA)

PTM type

Literature

Database

2N-acetylserine.Swiss-Prot 53.0
6Phosphotyrosine.Swiss-Prot 53.0
14Phosphotyrosine.Swiss-Prot 53.0
25Phosphotyrosine.Swiss-Prot 53.0
37Phosphoserine.Swiss-Prot 53.0
133S-palmitoyl cysteine (By similarity).Swiss-Prot 53.0
143S-palmitoyl cysteine (By similarity).Swiss-Prot 53.0
156S-palmitoyl cysteine (By similarity).Swiss-Prot 53.0
13Phosphotyrosine (Fyn;Src)12921535;14992595Phospho.ELM 6.0
79Phosphoserine11078729Phospho.ELM 6.0
36Phosphoserine15219854;17081983Phospho.ELM 6.0
167Phosphoserine11078729Phospho.ELM 6.0
24Phosphotyrosine15951569Phospho.ELM 6.0
5Phosphotyrosine15951569Phospho.ELM 6.0

Methylation Profile From DiseaseMeth database

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Chromosome

Location

Source

chr7

Promoter: 115950575 - 115952575Agilent_014791

chr7

Promoter: 115950575 - 115952575GoldenGate_Methylation_Cancer_Panel_I

chr7

Promoter: 115950575 - 115952575GSE27584

chr7

Promoter: 115950575 - 115952575PMID:16328005

chr7

Promoter: 115950575 - 115952575PMID:16952549

chr7

Promoter: 115950575 - 115952575PMID:16367923

chr7

Promoter: 115950575 - 115952575PMID:17341888

chr7

Promoter: 115950575 - 115952575PMID:15375584

chr7

Promoter: 115950575 - 115952575PMID:11170154


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