| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10004783 | HBV | ENSG00000116329.12 | protein_coding | OPRD1 | No | No | 4985 | P41143 |
| TVIS30074531 | HIV | ENSG00000116329.12 | protein_coding | OPRD1 | No | No | 4985 | P41143 |
| TVIS30022908 | HIV | ENSG00000116329.12 | protein_coding | OPRD1 | No | No | 4985 | P41143 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | OPRD1 |
|---|---|
| DrugBank ID | DB00704 |
| Drug Name | Naltrexone |
| Target ID | BE0000420 |
| UniProt ID | P41143 |
| Regulation Type | antagonist |
| PubMed IDs | 11752352; 15788780; 17661275; 17487229; 9673788; 9040115 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Roy S, Guo X, Kelschenbach J, Liu Y, Loh HH: In vivo activation of a mutant mu-opioid receptor by naltrexone produces a potent analgesic effect but no tolerance: role of mu-receptor activation and delta-receptor blockade in morphine tolerance. J Neurosci. 2005 Mar 23;25(12):3229-33.@@Barrios de Tomasi E, Juarez-Gonzalez J: [Opioid antagonists and alcohol consumption]. Rev Neurol. 2007 Aug 1-15;45(3):155-62.@@Weerts EM, Kim YK, Wand GS, Dannals RF, Lee JS, Frost JJ, McCaul ME: Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. Neuropsychopharmacology. 2008 Feb;33(3):653-65. Epub 2007 May 9.@@Herz A: Opioid reward mechanisms: a key role in drug abuse? Can J Physiol Pharmacol. 1998 Mar;76(3):252-8.@@Herz A: Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berl). 1997 Jan;129(2):99-111. |
| Groups | Approved; Investigational; Vet_approved |
| Direct Classification | Phenanthrenes and derivatives |
| SMILES | [H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@]([H])(C4)[C@]1(O)CCC2=O |
| Pathways | Naltrexone Action Pathway |
| PharmGKB | PA450588 |
| ChEMBL | CHEMBL19019 |
