| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10017570 | HBV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30010694 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30052490 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30052491 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30052492 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30052493 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30052494 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HTR2B |
|---|---|
| DrugBank ID | DB00715 |
| Drug Name | Paroxetine |
| Target ID | BE0000393 |
| UniProt ID | P41595 |
| Regulation Type | agonist |
| PubMed IDs | 25342944; 20846463; 25750618 |
| Citations | Peng L, Gu L, Li B, Hertz L: Fluoxetine and all other SSRIs are 5-HT2B Agonists - Importance for their Therapeutic Effects. Curr Neuropharmacol. 2014 Jul;12(4):365-79. doi: 10.2174/1570159X12666140828221720.@@Zhang S, Li B, Lovatt D, Xu J, Song D, Goldman SA, Nedergaard M, Hertz L, Peng L: 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'. Neuron Glia Biol. 2010 May;6(2):113-25. doi: 10.1017/S1740925X10000141. Epub 2010 Sep 16.@@Hertz L, Rothman DL, Li B, Peng L: Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift. Front Behav Neurosci. 2015 Feb 20;9:25. doi: 10.3389/fnbeh.2015.00025. eCollection 2015. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylpiperidines |
| SMILES | FC1=CC=C(C=C1)[C@@H]1CCNC[C@H]1COC1=CC2=C(OCO2)C=C1 |
| Pathways | |
| PharmGKB | PA450801 |
| ChEMBL | CHEMBL490 |
