| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10017570 | HBV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30010694 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30052490 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30052491 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30052492 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30052493 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
| TVIS30052494 | HIV | ENSG00000135914.6 | protein_coding | HTR2B | No | No | 3357 | P41595 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HTR2B |
|---|---|
| DrugBank ID | DB00248 |
| Drug Name | Cabergoline |
| Target ID | BE0000393 |
| UniProt ID | P41595 |
| Regulation Type | agonist |
| PubMed IDs | 18691132; 10641988; 20426763; 18992242; 19570945 |
| Citations | Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67.@@Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S.@@Sharif NA: Serotonin-2 receptor agonists as novel ocular hypotensive agents and their cellular and molecular mechanisms of action. Curr Drug Targets. 2010 Aug;11(8):978-93.@@Sharif NA, McLaughlin MA, Kelly CR, Katoli P, Drace C, Husain S, Crosson C, Toris C, Zhan GL, Camras C: Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes. Exp Eye Res. 2009 Mar;88(3):386-97. doi: 10.1016/j.exer.2008.10.003. Epub 2008 Nov 1.@@Huang XP, Setola V, Yadav PN, Allen JA, Rogan SC, Hanson BJ, Revankar C, Robers M, Doucette C, Roth BL: Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment. Mol Pharmacol. 2009 Oct;76(4):710-22. doi: 10.1124/mol.109.058057. Epub 2009 Jul 1. |
| Groups | Approved |
| Direct Classification | Lysergic acids and derivatives |
| SMILES | [H][C@@]12CC3=CNC4=CC=CC(=C34)[C@@]1([H])C[C@H](CN2CC=C)C(=O)N(CCCN(C)C)C(=O)NCC |
| Pathways | |
| PharmGKB | PA448708 |
| ChEMBL | CHEMBL1201087 |
