| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44045428 | HTLV-1 | ENSG00000091831.25 | protein_coding | ESR1 | Yes | No | 2099 | A0A125SXW3 G4XH65 H0Y4W6 P03372 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ESR1 |
|---|---|
| DrugBank ID | DB00421 |
| Drug Name | Spironolactone |
| Target ID | BE0010245 |
| UniProt ID | Q92731 |
| Regulation Type | agonist |
| PubMed IDs | 6849751; 7391714 |
| Citations | Fernandez MD, Carter GD, Palmer TN: The interaction of canrenone with oestrogen and progesterone receptors in human uterine cytosol. Br J Clin Pharmacol. 1983 Jan;15(1):95-101. doi: 10.1111/j.1365-2125.1983.tb01470.x.@@Levy J, Burshell A, Marbach M, Afllalo L, Glick SM: Interaction of spironolactone with oestradiol receptors in cytosol. J Endocrinol. 1980 Mar;84(3):371-9. doi: 10.1677/joe.0.0840371. |
| Groups | Approved |
| Direct Classification | Spironolactones and derivatives |
| SMILES | [H][C@@]12CC[C@@]3(CCC(=O)O3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@]([H])(CC2=CC(=O)CC[C@]12C)SC(C)=O |
| Pathways | Spironolactone Action Pathway |
| PharmGKB | PA451483 |
| ChEMBL | CHEMBL1393 |
