| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44047170 | HTLV-1 | ENSG00000140009.19 | protein_coding | ESR2 | No | No | 2100 | Q92731 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ESR2 |
|---|---|
| DrugBank ID | DB01108 |
| Drug Name | Trilostane |
| Target ID | BE0000792 |
| UniProt ID | Q92731 |
| Regulation Type | allosteric modulator |
| PubMed IDs | 17109615; 12209583; 16806905 |
| Citations | Puddefoot JR, Barker S, Vinson GP: Trilostane in advanced breast cancer. Expert Opin Pharmacother. 2006 Dec;7(17):2413-9.@@Puddefoot JR, Barker S, Glover HR, Malouitre SD, Vinson GP: Non-competitive steroid inhibition of oestrogen receptor functions. Int J Cancer. 2002 Sep 1;101(1):17-22.@@Barker S, Malouitre SD, Glover HR, Puddefoot JR, Vinson GP: Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: up-regulation of oestrogen receptor beta. J Steroid Biochem Mol Biol. 2006 Aug;100(4-5):141-51. Epub 2006 Jun 27. |
| Groups | Approved; Investigational; Vet_approved; Withdrawn |
| Direct Classification | Estrane steroids |
| SMILES | [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]23O[C@@H]2C(O)=C(C[C@]13C)C#N |
| Pathways | |
| PharmGKB | PA164748507 |
| ChEMBL | CHEMBL1200907 |
