Gene: ADARB2

105
ADAR3|RED2
adenosine deaminase, RNA specific B2 (inactive)
protein-coding
10p15.3
Ensembl:ENSG00000185736 MIM:602065 Vega:OTTHUMG00000017543 UniprotKB:Q9NS39
NC_000010.11
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.303e-1 (AD)  1.613e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7086346chr10:1623626 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs11250672chr10:1623271 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1112787chr10:1604704 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AMER20.697
FAXDC20.689
TESK20.686
SYT90.684
PHLPP10.677
ANXA90.663
KIF60.656
HSPA20.652
RDX0.648
NCKAP50.647

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH3BP1-0.338
GPR68-0.319
ARC-0.318
GSDMA-0.309
KLK5-0.302
NAT16-0.302
CD163L1-0.301
PDE6G-0.3
PNOC-0.297
VGF-0.297

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ADARB2 mRNA"28903501
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ADARB2 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ADARB2 mRNA"28973690
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ADARB2 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of ADARB2 mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of ADARB2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ADARB2 mRNA22100608
C006780bisphenol Abisphenol A results in decreased expression of ADARB2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of ADARB2 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of ADARB2 gene28505145
D003471CuprizoneCuprizone results in decreased expression of ADARB2 mRNA27523638
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ADARB2 mRNA29097150
C540355fenamidonefenamidone results in decreased expression of ADARB2 mRNA27029645
D005419FlavonoidsFlavonoids results in increased expression of ADARB2 mRNA18035473
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ADARB2 mRNA25613284
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of ADARB2 mRNA22401849
C028473N-acetyl-4-benzoquinoneimineADARB2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine21177773
D010100OxygenOxygen deficiency results in increased expression of ADARB2 mRNA26516004
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADARB2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ADARB2 mRNA25613284
D014635Valproic AcidValproic Acid results in increased methylation of ADARB2 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ADARB2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003725double-stranded RNA binding-IBA21873635  
GO:0003725double-stranded RNA binding-TAS10836796  
GO:0003726double-stranded RNA adenosine deaminase activity-IBA21873635  
GO:0003727single-stranded RNA binding-TAS10836796  
GO:0004000adenosine deaminase activity-IEA-  
GO:0008251tRNA-specific adenosine deaminase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006382adenosine to inosine editing-IBA21873635  
GO:0006396RNA processing-IBA21873635  
GO:0006397mRNA processing-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005730nucleolus-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal