Gene: CHN2

1124
ARHGAP3|BCH|CHN2-3|RHOGAP3
chimerin 2
protein-coding
7p14.3
Ensembl:ENSG00000285162 MIM:602857 Vega:OTTHUMG00000023063 UniprotKB:P52757
NG_029365.2
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.158e-1 (AD)  8.812e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3812350chr7:29282967 (GRCh38.p7)G>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs39109chr7:29279650 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC24A20.871
FOXP20.867
YPEL20.857
TMEFF20.851
B3GALT20.847
HS3ST50.842
THEMIS0.841
DACH10.838
RXFP10.835
TTLL70.832

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GJB2-0.49
ASB4-0.466
MAPKAPK3-0.461
SLC2A4-0.458
CYP11A1-0.443
ACOX2-0.442
MSX1-0.438
INHBB-0.437
SIX5-0.435
DDR2-0.435

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CHN2 mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CHN2 mRNA"19162173
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHN2 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CHN2 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHN2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHN2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHN2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHN2 mRNA"25510870
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CHN2 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CHN2 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CHN2 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of CHN2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CHN2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CHN2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CHN2 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CHN2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CHN2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHN2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHN2 mRNA15034205|1977048
D004958EstradiolEstradiol affects the expression of CHN2 mRNA23557687
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of CHN2 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of CHN2 mRNA23019147
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of CHN2 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of CHN2 mRNA25210133
C006780bisphenol Abisphenol A results in decreased expression of CHN2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CHN2 gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHN2 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of CHN2 mRNA24386269
D003471CuprizoneCuprizone results in decreased expression of CHN2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of CHN2 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of CHN2 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CHN2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of CHN2 mRNA27594783
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of CHN2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of CHN2 mRNA19467301
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of CHN2 mRNA"23811387
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CHN2 mRNA29097150
D018120FinasterideFinasteride results in increased expression of CHN2 mRNA24136188
D005419FlavonoidsFlavonoids results in decreased expression of CHN2 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHN2 mRNA20938992
D019833GenisteinGenistein results in decreased expression of CHN2 mRNA23019147
D017313FenretinideFenretinide results in decreased expression of CHN2 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CHN2 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CHN2 mRNA18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CHN2 mRNA25613284
C410337K 7174K 7174 results in decreased expression of CHN2 mRNA24086573
C045463leflunomideleflunomide results in increased expression of CHN2 mRNA28988120
C045463leflunomideleflunomide results in increased expression of CHN2 mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHN2 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CHN2 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of CHN2 mRNA27544571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CHN2 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of CHN2 mRNA24810058
D009285NaphthoquinonesNaphthoquinones results in increased expression of CHN2 mRNA23811387
D009525NiacinNiacin results in increased expression of CHN2 mRNA20303128
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of CHN2 mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the methylation of CHN2 gene19233941
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of CHN2 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of CHN2 mRNA17426115|1830175
D011374ProgesteroneProgesterone results in increased expression of CHN2 mRNA20631399
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of CHN2 mRNA20660070
D011794QuercetinQuercetin results in decreased expression of CHN2 mRNA21632981
D012643SeleniumSelenium results in increased expression of CHN2 mRNA19244175
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of CHN2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CHN2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHN2 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHN2 mRNA15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CHN2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CHN2 mRNA25613284
D013849ThimerosalThimerosal results in increased expression of CHN2 mRNA27188386
D014241TrichloroethyleneTrichloroethylene results in increased expression of CHN2 mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CHN2 mRNA24935251|2627250
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CHN2 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of CHN2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of CHN2 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CHN2 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CHN2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of CHN2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005070SH3/SH2 adaptor activity-TAS8175705  
GO:0005096GTPase activator activity-TAS-  
GO:0005515protein binding-IPI16628218  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0009967positive regulation of signal transduction-IEA-  
GO:0035556intracellular signal transduction-IEA-  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23941981Association of a novel polymorphism of the beta2-chimaerin gene (CHN2) with smoking. (2013 Oct)Barrio-Real LJ Investig Med
23747354Over-expression of the miRNA cluster at chromosome 14q32 in the alcoholic brain correlates with suppression of predicted target mRNA required for oligodendrocyte proliferation. (2013 Sep 10)Manzardo AMGene