Gene: OSBPL1A

114876
ORP-1|ORP1|OSBPL1B
oxysterol binding protein like 1A
protein-coding
18q11.2
Ensembl:ENSG00000141447 MIM:606730 Vega:OTTHUMG00000131944 UniprotKB:Q9BXW6
NG_029432.1
SNP Mapped
3   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.819e-1 (AD)  5.584e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1532010chr18:24348077 (GRCh38.p7)G>A / G>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs4281802chr18:24226736 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs17203129chr18:24212686 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPRD1A0.934
EPS150.928
RAP1GDS10.928
ZRANB10.928
SERINC30.925
FBXO450.924
PPM1A0.921
OPTN0.92
CDC42SE20.919
VAPB0.918

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.626
OR4F5-0.603
MTRNR2L10-0.377
KLRB1-0.351
MTRNR2L3-0.348
C8orf74-0.34
MTRNR2L6-0.335
MDFI-0.333
KCNK5-0.332
RNF135-0.332

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of OSBPL1A mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of OSBPL1A mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of OSBPL1A mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of OSBPL1A mRNA]"19467301
C547126AZM551248AZM551248 results in decreased expression of OSBPL1A mRNA22323515
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of OSBPL1A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of OSBPL1A mRNA20127859|2050435
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of OSBPL1A mRNA"20018196
C044887beta-methylcholinebeta-methylcholine affects the expression of OSBPL1A mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of OSBPL1A mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of OSBPL1A mRNA25181051
D002065BuspironeBuspirone results in decreased expression of OSBPL1A mRNA24136188
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of OSBPL1A mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of OSBPL1A mRNA25993096
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OSBPL1A gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of OSBPL1A mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of OSBPL1A mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of OSBPL1A mRNA24612858
D003042CocaineCocaine results in decreased expression of OSBPL1A mRNA15009677
D003300CopperCopper results in decreased expression of OSBPL1A mRNA18522721
D016572CyclosporineCyclosporine results in decreased expression of OSBPL1A mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of OSBPL1A mRNA19770486
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of OSBPL1A mRNA24317228
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of OSBPL1A mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of OSBPL1A mRNA27392435
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of OSBPL1A mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of OSBPL1A mRNA19467301
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of OSBPL1A mRNA19638242
D002117CalcitriolCalcitriol results in increased expression of OSBPL1A mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of OSBPL1A mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of OSBPL1A mRNA"22485181
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of OSBPL1A mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of OSBPL1A mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OSBPL1A mRNA17942748
C082360fipronilfipronil results in decreased expression of OSBPL1A mRNA23962444
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OSBPL1A gene20938992
D017313FenretinideFenretinide results in decreased expression of OSBPL1A mRNA28973697
C492448ICG 001ICG 001 results in increased expression of OSBPL1A mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OSBPL1A mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of OSBPL1A mRNA27392435
C544151jinfukangjinfukang results in increased expression of OSBPL1A mRNA27392435
D007854LeadLead affects the expression of OSBPL1A mRNA28903495
D064704LevofloxacinLevofloxacin results in decreased expression of OSBPL1A mRNA24136188
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of OSBPL1A gene20938992
C004925methylmercuric chloridemethylmercuric chloride affects the expression of OSBPL1A protein27012723
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of OSBPL1A protein26558463
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of OSBPL1A mRNA"26251327
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of OSBPL1A protein26558463
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of OSBPL1A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of OSBPL1A mRNA"25554681
D009532NickelNickel results in decreased expression of OSBPL1A mRNA25583101
C016340o,p'-DDT"o,p'-DDT affects the expression of OSBPL1A mRNA"17984292
D010100OxygenOxygen deficiency results in increased expression of OSBPL1A mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of OSBPL1A mRNA]22629407
D010126OzoneOzone results in decreased expression of OSBPL1A mRNA16183385
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of OSBPL1A mRNA18593933
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of OSBPL1A protein19474218
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of OSBPL1A mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of OSBPL1A mRNA24677778
D011374ProgesteroneProgesterone results in increased expression of OSBPL1A mRNA19690047
D011441PropylthiouracilPropylthiouracil results in decreased expression of OSBPL1A mRNA24780913
D012643Selenium[Selenium co-treated with Vitamin E] results in decreased expression of OSBPL1A mRNA19244175
D012643SeleniumSelenium results in decreased expression of OSBPL1A mRNA19244175
D019821SimvastatinSimvastatin results in decreased expression of OSBPL1A mRNA25055962
D013629TamoxifenTamoxifen affects the expression of OSBPL1A mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of OSBPL1A mRNA21592394
D013739TestosteroneTestosterone results in increased expression of OSBPL1A mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of OSBPL1A mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of OSBPL1A mRNA20106945
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of OSBPL1A mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of OSBPL1A mRNA25613284
D014520UrethaneUrethane results in increased expression of OSBPL1A mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of OSBPL1A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of OSBPL1A mRNA23179753|2493525
D014640VancomycinVancomycin results in increased expression of OSBPL1A mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of OSBPL1A gene25560391
C025643vinclozolinvinclozolin affects the expression of OSBPL1A mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of OSBPL1A mRNA18042343
C029297vinylidene chloridevinylidene chloride results in decreased expression of OSBPL1A mRNA26682919
D014810Vitamin E[Selenium co-treated with Vitamin E] results in decreased expression of OSBPL1A mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of OSBPL1A mRNA19244175
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of OSBPL1A mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16176980  
GO:0005543phospholipid binding-NAS11279184  
GO:0008289lipid binding-IBA21873635  
GO:0015248sterol transporter activity-IBA21873635  
GO:0015248sterol transporter activity-TAS-  
GO:0015485cholesterol binding-IBA21873635  
GO:0032934sterol binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006699bile acid biosynthetic process-TAS-  
GO:0008203cholesterol metabolic process-NAS10588946  
GO:0015918sterol transport-IEA-  
GO:0016192vesicle-mediated transport-NAS11279184  
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005770late endosome-IDA16176980  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0016020membrane-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1430728MetabolismTAS
R-HSA-168256Immune SystemTAS
R-HSA-192105Synthesis of bile acids and bile saltsTAS
R-HSA-194068Bile acid and bile salt metabolismTAS
R-HSA-2132295MHC class II antigen presentationTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal