Gene: ENPP6

133121
NPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
protein-coding
4q35.1
Ensembl:ENSG00000164303 MIM:616983 Vega:OTTHUMG00000160617 UniprotKB:Q6UWR7
NC_000004.12
SNP Mapped
3   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.441e-2 (AD)  6.627e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1882331chr4:184202613 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6552767chr4:184188841 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11132226chr4:184144142 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNAI10.838
KIAA1324L0.821
EML10.816
LDLRAD40.812
IFT800.802
LPGAT10.797
ANO40.797
LRRC8D0.792
TMEFF20.791
TMEM640.789

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYPL2-0.526
ZIC5-0.509
ZIC2-0.508
EVC2-0.494
RFX2-0.491
EYA2-0.483
GRTP1-0.481
NHSL1-0.479
CDC14A-0.479
INHBB-0.477

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of ENPP6 mRNA28522335
D000082AcetaminophenAcetaminophen results in decreased expression of ENPP6 mRNA26690555
D020106AcrylamideAcrylamide results in increased expression of ENPP6 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ENPP6 mRNA21298039
D001280AtrazineAtrazine results in decreased expression of ENPP6 mRNA25929836
C006780bisphenol Abisphenol A affects the expression of ENPP6 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of ENPP6 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ENPP6 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ENPP6 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ENPP6 promoter22457795
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of ENPP6 mRNA26033743
D003300CopperCopper deficiency results in increased expression of ENPP6 mRNA26033743
D003471CuprizoneCuprizone affects the expression of ENPP6 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ENPP6 mRNA20106945
D004041Dietary FatsDietary Fats results in increased expression of ENPP6 mRNA25016146
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of ENPP6 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of ENPP6 mRNA26033743
C118739entinostatentinostat results in increased expression of ENPP6 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ENPP6 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ENPP6 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENPP6 mRNA17942748
C412815GW 4064GW 4064 results in increased expression of ENPP6 mRNA26655953
C008261lead acetatelead acetate results in increased expression of ENPP6 mRNA22641619
D008694MethamphetamineMethamphetamine results in decreased expression of ENPP6 mRNA28619521
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of ENPP6 mRNA24128854
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of ENPP6 mRNA"23246600
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ENPP6 mRNA19710929
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ENPP6 mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of ENPP6 mRNA24780913
D012715Sesame OilSesame Oil results in decreased expression of ENPP6 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ENPP6 mRNA23806026
D013629TamoxifenTamoxifen affects the expression of ENPP6 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ENPP6 mRNA17942748
D014635Valproic AcidValproic Acid affects the expression of ENPP6 mRNA25979313
C025643vinclozolinvinclozolin results in increased expression of ENPP6 mRNA23034163
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of ENPP6 mRNA"23246600
C088658zoledronic acidzoledronic acid results in increased expression of ENPP6 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008081phosphoric diester hydrolase activity-IDA15788404  
GO:0008889glycerophosphodiester phosphodiesterase activity-IEA-  
GO:0047390glycerophosphocholine cholinephosphodiesterase activity-EXP15788404  
GO:0047390glycerophosphocholine cholinephosphodiesterase activity-IDA15788404  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-IDA15788404  
GO:0019695choline metabolic process-IDA15788404  
GO:0046475glycerophospholipid catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA15788404  
GO:0005886plasma membrane-IDA15788404  
GO:0005886plasma membrane-TAS-  
GO:0031225anchored component of membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00565Ether lipid metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6814848Glycerophospholipid catabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal