Gene: CTNNA2

1496
CAP-R|CAPR|CT114|CTNR
catenin alpha 2
protein-coding
2p12
Ensembl:ENSG00000066032 MIM:114025 Vega:OTTHUMG00000152903 UniprotKB:P26232
NC_000002.12
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.407e-1 (AD)  1.741e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7605261chr2:80544065 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs13423141chr2:80543683 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1434075chr2:80516069 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10170918chr2:80039771 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCG30.911
GPM6A0.902
LSAMP0.888
ABAT0.886
SNN0.881
NTM0.88
FAM168A0.876
DCAF110.873
ATPAF10.872
GABBR10.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.745
OR4F29-0.691
SGMS2-0.375
TRPV5-0.366
SH2D1A-0.361
BEST3-0.346
HAS2-0.34
VRK2-0.327
ANXA13-0.322
IGF2BP2-0.321

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CTNNA2 mRNA"25614096
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of CTNNA2 mRNA"20406850
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CTNNA2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNA2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CTNNA2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CTNNA2 gene27153756
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of CTNNA2 mRNA"22863853
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CTNNA2 gene25435355
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of CTNNA2 mRNA20660070
D004958EstradiolEstradiol results in increased expression of CTNNA2 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of CTNNA2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CTNNA2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CTNNA2 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of CTNNA2 mRNA22079614
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CTNNA2 protein24527689
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTNNA2 mRNA20938992
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of CTNNA2 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CTNNA2 mRNA21266533
D002117CalcitriolCalcitriol results in increased expression of CTNNA2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CTNNA2 mRNA21592394
D004147DioxinsDioxins affects the expression of CTNNA2 mRNA20463971
C118739entinostatentinostat results in decreased expression of CTNNA2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNA2 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CTNNA2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTNNA2 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTNNA2 mRNA20938992
C039281furanfuran results in increased expression of CTNNA2 mRNA25539665
D007052IbuprofenIbuprofen results in increased expression of CTNNA2 mRNA28201806
D008353MannitolMannitol results in decreased expression of CTNNA2 mRNA25270620
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CTNNA2 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride affects the expression of CTNNA2 protein27012723
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CTNNA2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CTNNA2 mRNA26011545
D009151Mustard GasMustard Gas results in increased expression of CTNNA2 mRNA15674843
D010126OzoneOzone results in decreased expression of CTNNA2 mRNA12763052
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNA2 mRNA"27188386
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of CTNNA2 mRNA20660070
C017947sodium arsenitesodium arsenite affects the methylation of CTNNA2 gene28589171
D012999SomanSoman results in decreased expression of CTNNA2 mRNA19281266
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CTNNA2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CTNNA2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CTNNA2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CTNNA2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CTNNA2 mRNA22298810
D013893ThiramThiram results in increased expression of CTNNA2 mRNA20530235
D014118Toxins, Biological"Toxins, Biological affects the expression of CTNNA2 mRNA"19682533
D014212TretinoinTretinoin affects the expression of CTNNA2 mRNA16211290
D014635Valproic AcidValproic Acid affects the expression of CTNNA2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of CTNNA2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CTNNA2 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CTNNA2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005200structural constituent of cytoskeleton-NAS8432524  
GO:0005515protein binding-IPI16182284  
GO:0042802identical protein binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO:0051015actin filament binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IEA-  
GO:0007409axonogenesis-ISS-  
GO:0021942radial glia guided migration of Purkinje cell-ISS-  
GO:0048813dendrite morphogenesis-ISS-  
GO:0048854brain morphogenesis-ISS-  
GO:0051149positive regulation of muscle cell differentiation-TAS-  
GO:0051823regulation of synapse structural plasticity-ISS-  
GO:0060134prepulse inhibition-ISS-  
GO:0098609cell-cell adhesion-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IDA16182284  
GO:0005829cytosol-TAS-  
GO:0005912adherens junction-ISS-  
GO:0005913cell-cell adherens junction-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0015629actin cytoskeleton-IEA-  
GO:0016323basolateral plasma membrane-IEA-  
GO:0030027lamellipodium-IEA-  
GO:0030424axon-ISS-  
KEGG ID KEGG Term
hsa04520Adherens junction
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer
hsa05213Endometrial cancer
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-375170CDO in myogenesisTAS
R-HSA-375170CDO in myogenesisIEA
R-HSA-525793MyogenesisTAS
R-HSA-525793MyogenesisIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24268366Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure. (2014 Jan)Yang TYEnviron Res
18163523Regulation of a novel alphaN-catenin splice variant in schizophrenic smokers. (2008 Sep 5)Mexal SAm J Med Genet B Neuropsychiatr Genet
28823962Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer. (2017 Oct 28)Nakagawa TCancer Lett
25041903TARV: tree-based analysis of rare variants identifying risk modifying variants in CTNNA2 and CNTNAP2 for alcohol addiction. (2014 Sep)Song CGenet Epidemiol