Gene: CTNND2

1501
GT24|NPRAP
catenin delta 2
protein-coding
5p15.2
Ensembl:ENSG00000169862 MIM:604275 Vega:OTTHUMG00000090511 UniprotKB:Q9UQB3
NG_023544.1
SNP Mapped
OD|ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.481e-1 (AD)  3.708e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10044218chr5:11412934 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs6869903chr5:11300742 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10052295chr5:10977210 (GRCh38.p7)A>Gopioid dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNB10.934
SCRN10.926
EEF20.92
TNPO20.915
CDC42BPB0.906
SLC25A230.904
B3GAT10.903
UBQLN40.903
ZBTB40.901
ACO20.901

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.816
OR4F5-0.812
IL24-0.281
SLAMF6-0.273
TFPI2-0.272
C9orf135-0.27
TRIM10-0.264
DPPA4-0.264
PRRX2-0.257
SLC4A1-0.257

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CTNND2 mRNA"26377693
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of CTNND2 mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C0587225-hydroxy-6,8,11,14,17-eicosapentaenoic acid"5-hydroxy-6,8,11,14,17-eicosapentaenoic acid affects the expression of CTNND2 mRNA"26984781
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of CTNND2 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CTNND2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CTNND2 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of CTNND2 mRNA25929836
C547126AZM551248AZM551248 results in increased expression of CTNND2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of CTNND2 mRNA21714911
D004958EstradiolEstradiol affects the expression of CTNND2 mRNA25321415
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CTNND2 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of CTNND2 mRNA19619570|2118537
D004958EstradiolEstradiol results in increased expression of CTNND2 mRNA17555868|2301914
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of CTNND2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of CTNND2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of CTNND2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of CTNND2 protein24552547
C013418bromfenacoumbromfenacoum results in decreased expression of CTNND2 protein28903499
D002101Cacodylic AcidCacodylic Acid results in increased expression of CTNND2 mRNA17441966
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CTNND2 mRNA24763279
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of CTNND2 mRNA26272509
D003042CocaineCocaine results in decreased expression of CTNND2 mRNA12629581
D003042CocaineCocaine results in increased expression of CTNND2 mRNA16076954
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of CTNND2 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of CTNND2 mRNA19167446
D016578Crack CocaineCrack Cocaine results in increased expression of CTNND2 mRNA12629581
C009160cyclonitecyclonite results in increased expression of CTNND2 mRNA25559034
D003520CyclophosphamideCTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D004317DoxorubicinCTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
C118739entinostatentinostat results in decreased expression of CTNND2 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
D005472FluorouracilCTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
D004397FonofosFonofos results in increased methylation of CTNND2 promoter22847954
D019833GenisteinGenistein results in increased expression of CTNND2 mRNA23019147
C071834glycidamideglycidamide results in decreased expression of CTNND2 mRNA17822822
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of CTNND2 mRNA24763279
C042720mercuric bromidemercuric bromide results in decreased expression of CTNND2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CTNND2 mRNA28001369
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of CTNND2 mRNA22108045
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CTNND2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CTNND2 mRNA"25554681
D009532NickelNickel results in decreased expression of CTNND2 mRNA24768652|2558310
D017239PaclitaxelCTNND2 mRNA affects the susceptibility to [Paclitaxel co-treated with Fluorouracil co-treated with Doxorubicin co-treated with Cyclophosphamide]16896004
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of CTNND2 mRNA26272509
D010269ParaquatParaquat results in decreased expression of CTNND2 mRNA21371552
D010278ParathionParathion results in increased methylation of CTNND2 promoter22847954
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of CTNND2 mRNA27153767
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CTNND2 mRNA26272509
D010795Phthalic AcidsPhthalic Acids results in decreased expression of CTNND2 mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of CTNND2 mRNA20813756
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of CTNND2 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of CTNND2 mRNA22238285
C005556propionaldehydepropionaldehyde results in decreased expression of CTNND2 mRNA26079696
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of CTNND2 mRNA19167446
C017947sodium arsenitesodium arsenite affects the methylation of CTNND2 gene28589171
D053260SootSoot results in decreased expression of CTNND2 mRNA26551751
C012568terbufosterbufos results in increased methylation of CTNND2 promoter22847954
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CTNND2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CTNND2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CTNND2 mRNA17555868
C009495titanium dioxidetitanium dioxide results in increased expression of CTNND2 mRNA23557971
D014118Toxins, Biological"Toxins, Biological affects the expression of CTNND2 mRNA"19682533
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of CTNND2 mRNA24935251|2627250
D014415TunicamycinTunicamycin results in decreased expression of CTNND2 mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CTNND2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CTNND2 mRNA23179753|2438349
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNND2 mRNA"27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19706605  19706687  22022388  
GO:0008013beta-catenin binding-IPI25807484  
GO:0045296cadherin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007155cell adhesion-TAS9223106  
GO:0007165signal transduction-TAS9223106  
GO:0009966regulation of signal transduction-IBA21873635  
GO:0016055Wnt signaling pathway-IEA-  
GO:0050808synapse organization-IBA21873635  
GO:0050808synapse organization-IMP25807484  
GO:0060828regulation of canonical Wnt signaling pathway-IMP25807484  
GO:0060997dendritic spine morphogenesis-IBA21873635  
GO:0060997dendritic spine morphogenesis-IMP25807484  
GO:0098609cell-cell adhesion-IBA21873635  
GO:0098609cell-cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS9342840  
GO:0005886plasma membrane-IBA21873635  
GO:0005911cell-cell junction-IBA21873635  
GO:0005912adherens junction-IEA-  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0014069postsynaptic density-IBA21873635  
GO:0030425dendrite-IEA-  
GO:0043204perikaryon-IDA22022388  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal