Gene: ZFPM1

161882
FOG|FOG1|ZC2HC11A|ZNF408|ZNF89A
zinc finger protein, FOG family member 1
protein-coding
16q24.2
Ensembl:ENSG00000179588 MIM:601950 Vega:OTTHUMG00000173152 UniprotKB:Q8IX07
NC_000016.10
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.641e-2 (AD)  5.826e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3965782chr16:88510386 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs868874chr16:88503975 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg05183538chr16:88536950ZFPM11.400e-10Smoking27651444
cg01062937chr16:88537260ZFPM18.900e-9Smoking27651444
cg04387347chr16:88537187ZFPM11.900e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ANKRD90.853
PRR70.813
PCSK1N0.811
TPGS10.801
TMEM1600.801
TRAPPC50.778
CCDC85B0.772
ZNF7870.769
ZNF7710.764
ABHD17A0.758

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.429
CTNNA3-0.376
OR4F29-0.371
CDK6-0.357
ARHGAP11A-0.357
ZFP57-0.349
C18orf54-0.348
RNF125-0.343
LACC1-0.332
TCEANC2-0.331

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ZFPM1 mRNA"18648102
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of ZFPM1 mRNA20829426
D000082AcetaminophenAcetaminophen results in increased expression of ZFPM1 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of ZFPM1 mRNA17562736
C021139anagrelideanagrelide inhibits the reaction [THPO protein results in increased expression of ZFPM1 mRNA]20586925
D001151ArsenicArsenic affects the methylation of ZFPM1 gene25304211
D001280AtrazineAtrazine results in increased expression of ZFPM1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZFPM1 mRNA21569818|2222880
D004958EstradiolEstradiol affects the expression of ZFPM1 mRNA15598610
C006780bisphenol Abisphenol A results in decreased methylation of ZFPM1 promoter27312807
C006780bisphenol Abisphenol A results in increased expression of ZFPM1 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of ZFPM1 mRNA20977926
D002994ClofibrateClofibrate results in decreased expression of ZFPM1 mRNA17585979
D003042CocaineCocaine results in increased expression of ZFPM1 mRNA18355967
D003042CocaineFOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ZFPM1 mRNA]18355967
D003375CoumestrolCoumestrol results in decreased expression of ZFPM1 mRNA19167446
D013759DronabinolDronabinol results in decreased expression of ZFPM1 mRNA16616335
D003976DiazinonDiazinon results in increased methylation of ZFPM1 gene22964155
C000944dicrotophosdicrotophos results in increased expression of ZFPM1 mRNA28302478
D004041Dietary FatsDietary Fats affects the expression of ZFPM1 mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of ZFPM1 mRNA25016146
D004317DoxorubicinDoxorubicin results in decreased expression of ZFPM1 mRNA16243910
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ZFPM1 mRNA17555576
C082360fipronilfipronil results in decreased expression of ZFPM1 mRNA23962444
C069837fullerene C60fullerene C60 results in decreased expression of ZFPM1 mRNA19167457
C004312glycidolglycidol results in increased expression of ZFPM1 mRNA24915197
D017313FenretinideFenretinide results in increased expression of ZFPM1 mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in decreased expression of ZFPM1 mRNA19376150
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZFPM1 mRNA23086925
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ZFPM1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ZFPM1 mRNA12057914
C005219methyl cellosolvemethyl cellosolve results in increased expression of ZFPM1 mRNA21061450
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ZFPM1 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ZFPM1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ZFPM1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of ZFPM1 mRNA19167457
D000073878Palm OilPalm Oil affects the expression of ZFPM1 mRNA19680557
D010795Phthalic AcidsPhthalic Acids results in increased expression of ZFPM1 mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ZFPM1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of ZFPM1 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ZFPM1 mRNA28903501
D018038Sodium SeleniteSodium Selenite results in increased expression of ZFPM1 mRNA18175754
D013629TamoxifenTamoxifen affects the expression of ZFPM1 mRNA17555576
D013629TamoxifenTamoxifen results in decreased expression of ZFPM1 mRNA25123088
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZFPM1 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ZFPM1 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZFPM1 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZFPM1 mRNA21215274
D019284ThapsigarginThapsigargin results in increased expression of ZFPM1 mRNA22378314
C009495titanium dioxidetitanium dioxide results in decreased expression of ZFPM1 mRNA23557971
D014212TretinoinTretinoin results in increased expression of ZFPM1 mRNA16604517
D014241TrichloroethyleneTrichloroethylene results in increased expression of ZFPM1 mRNA19448997
D014635Valproic AcidValproic Acid results in increased methylation of ZFPM1 gene29154799
C025643vinclozolinvinclozolin results in increased expression of ZFPM1 mRNA21126777

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA15920471  
GO:0001085RNA polymerase II transcription factor binding-IBA21873635  
GO:0001085RNA polymerase II transcription factor binding-IPI11675338  15920471  
GO:0001102RNA polymerase II activating transcription factor binding-IEA-  
GO:0005515protein binding-IPI19513100  21047798  21988832  
GO:0008134transcription factor binding-IPI12483298  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0002295T-helper cell lineage commitment-IC21646796  
GO:0003151outflow tract morphogenesis-ISS-  
GO:0003181atrioventricular valve morphogenesis-ISS-  
GO:0003192mitral valve formation-ISS-  
GO:0003195tricuspid valve formation-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007507heart development-IBA21873635  
GO:0007596blood coagulation-TAS-  
GO:0010724regulation of definitive erythrocyte differentiation-IDA15920471  
GO:0010724regulation of definitive erythrocyte differentiation-IMP17207461  
GO:0030154cell differentiation-IBA21873635  
GO:0030218erythrocyte differentiation-IBA21873635  
GO:0030218erythrocyte differentiation-ISS-  
GO:0030219megakaryocyte differentiation-IBA21873635  
GO:0030219megakaryocyte differentiation-ISS-  
GO:0030220platelet formation-IGI11675338  
GO:0030851granulocyte differentiation-IEA-  
GO:0032091negative regulation of protein binding-ISS-  
GO:0032642regulation of chemokine production-IEA-  
GO:0035162embryonic hemopoiesis-ISS-  
GO:0035855megakaryocyte development-IEA-  
GO:0045078positive regulation of interferon-gamma biosynthetic process-IDA21646796  
GO:0045403negative regulation of interleukin-4 biosynthetic process-IDA21646796  
GO:0045599negative regulation of fat cell differentiation-ISS-  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0055008cardiac muscle tissue morphogenesis-ISS-  
GO:0060318definitive erythrocyte differentiation-IEA-  
GO:0060319primitive erythrocyte differentiation-IEA-  
GO:0060377negative regulation of mast cell differentiation-ISS-  
GO:0060412ventricular septum morphogenesis-ISS-  
GO:0060413atrial septum morphogenesis-ISS-  
GO:0071733transcriptional activation by promoter-enhancer looping-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005667transcription factor complex-IDA15920471  
GO:0005737cytoplasm-IEA-  
GO:0017053transcriptional repressor complex-IDA15920471  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal