Gene: ADGRF5

221395
GPR116|KPG_001
adhesion G protein-coupled receptor F5
protein-coding
6p12.3
Ensembl:ENSG00000069122 Vega:OTTHUMG00000014793 UniprotKB:Q8IZF2
NC_000006.12
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.677e-1 (AD)  1.969e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6910089chr6:46904248 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs1004018chr6:46886666 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADGRF5 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ADGRF5 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ADGRF5 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADGRF5 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADGRF5 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADGRF5 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ADGRF5 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADGRF5 mRNA"25510870
D000082AcetaminophenAcetaminophen results in increased expression of ADGRF5 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of ADGRF5 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ADGRF5 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ADGRF5 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of ADGRF5 mRNA26705709
C547126AZM551248AZM551248 results in decreased expression of ADGRF5 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ADGRF5 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ADGRF5 mRNA21964900
D004958EstradiolEstradiol results in increased expression of ADGRF5 mRNA20068009
C006780bisphenol Abisphenol A affects the expression of ADGRF5 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADGRF5 mRNA16997883
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ADGRF5 promoter22457795
D002922CiguatoxinsCiguatoxins affects the expression of ADGRF5 mRNA18353800
C018021cobaltous chloridecobaltous chloride results in decreased expression of ADGRF5 mRNA19320972
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ADGRF5 mRNA23640034
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADGRF5 mRNA16997883
C082360fipronilfipronil results in increased expression of ADGRF5 mRNA23962444
D005839GentamicinsGentamicins results in decreased expression of ADGRF5 mRNA22061828
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of ADGRF5 mRNA16997883
D007545IsoproterenolIsoproterenol results in increased expression of ADGRF5 mRNA20003209
D008694MethamphetamineMethamphetamine results in increased expression of ADGRF5 mRNA26307267
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ADGRF5 mRNA"26251327
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ADGRF5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ADGRF5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ADGRF5 mRNA"25620056
D019829NevirapineNevirapine metabolite results in increased expression of ADGRF5 mRNA23947594
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of ADGRF5 mRNA19074003
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ADGRF5 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ADGRF5 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of ADGRF5 mRNA"25510870
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in increased expression of ADGRF5 mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ADGRF5 mRNA19465110
C009495titanium dioxidetitanium dioxide results in increased expression of ADGRF5 mRNA23557971
D014050TolueneToluene results in increased expression of ADGRF5 mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ADGRF5 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ADGRF5 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ADGRF5 mRNA21934132
C032910triadimefontriadimefon results in increased expression of ADGRF5 mRNA26705709
C012589trichostatin Atrichostatin A results in decreased expression of ADGRF5 mRNA26705709
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ADGRF5 mRNA19042947
D014635Valproic AcidValproic Acid results in decreased methylation of ADGRF5 gene29154799
C025643vinclozolinvinclozolin affects the expression of ADGRF5 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of ADGRF5 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003094glomerular filtration-IEA-  
GO:0006112energy reserve metabolic process-IEA-  
GO:0007166cell surface receptor signaling pathway-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-IEA-  
GO:0042593glucose homeostasis-IEA-  
GO:0043031negative regulation of macrophage activation-IEA-  
GO:0043129surfactant homeostasis-IEA-  
GO:0045444fat cell differentiation-IEA-  
GO:0048821erythrocyte development-IEA-  
GO:0061626pharyngeal arch artery morphogenesis-IEA-  
GO:0071073positive regulation of phospholipid biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0009986cell surface-IDA23684610  
GO:0016021integral component of membrane-IEA-  
GO:0031410cytoplasmic vesicle-IDA23684610  
GO:0045177apical part of cell-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5683826Surfactant metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal