Gene: KIF6

221458
C6orf102|dJ1043E3.1|dJ137F1.4|dJ188D3.1
kinesin family member 6
protein-coding
6p21.2
Ensembl:ENSG00000164627 MIM:613919 Vega:OTTHUMG00000014648 UniprotKB:Q6ZMV9
NG_054928.1
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
2   
3.609e-1 (AD)  8.568e-1 (ND)   (Frontal_Cortex)
6.074e-1 (AD)  8.343e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1026526chr6:39619981 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs9394619chr6:39606601 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6901155chr6:39532803 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)
rs4236064chr6:39446251 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FOLH10.831
BTBD160.827
RHBDL20.826
CLCA40.825
DNAH170.824
ST180.821
NIPAL40.81
POU2AF10.807
TP53TG50.804
ASPA0.802

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.41
TCERG1L-0.397
NEUROD1-0.377
TP53I11-0.375
HCN4-0.371
GPR153-0.367
CHRNA2-0.367
TAC3-0.364
PCDH8-0.362
BEAN1-0.358

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0112692,5-hexanedione"2,5-hexanedione results in increased expression of KIF6 mRNA"22952946
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF6 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of KIF6 protein22230336
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KIF6 mRNA16483693
D001151ArsenicArsenic affects the methylation of KIF6 gene25304211
D000069059Atorvastatin CalciumKIF6 polymorphism results in increased susceptibility to Atorvastatin Calcium21943003
C006780bisphenol Abisphenol A affects the expression of KIF6 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of KIF6 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of KIF6 mRNA25181051
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of KIF6 mRNA]20360939
D003471CuprizoneCuprizone results in increased expression of KIF6 mRNA26577399
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of KIF6 mRNA21266533
D004052Diethylnitrosaminecaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of KIF6 mRNA]20360939
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of KIF6 mRNA20360939
C118739entinostatentinostat results in increased expression of KIF6 mRNA27188386
D007213IndomethacinIndomethacin results in increased expression of KIF6 mRNA28201806
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in decreased expression of KIF6 mRNA28349193
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of KIF6 mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of KIF6 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KIF6 mRNA"25554681
D053260SootSoot results in decreased expression of KIF6 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of KIF6 mRNA21354282
C012589trichostatin Atrichostatin A results in increased expression of KIF6 mRNA27188386
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF6 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of KIF6 mRNA23179753|2438349
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KIF6 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of KIF6 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003777microtubule motor activity-IBA21873635  
GO:0005515protein binding-IPI16189514  19060904  
GO:0005524ATP binding-IEA-  
GO:0008017microtubule binding-IBA21873635  
GO:0008017microtubule binding-IEA-  
GO:0016887ATPase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007018microtubule-based movement-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001673male germ cell nucleus-IEA-  
GO:0005737cytoplasm-IEA-  
GO:0005871kinesin complex-IBA21873635  
GO:0005874microtubule-IBA21873635  
GO:0005874microtubule-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6811434COPI-dependent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-983189KinesinsTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28097184KIF6 719Arg Genetic Variant and Risk for Thoracic Aortic Dissection. (2016 Jun)Iakoubova OAAorta (Stamford)
26236646Genotyping and meta-analysis of KIF6 Trp719Arg polymorphism in South Indian Coronary Artery Disease patients: A case-control study. (2015 Sep)Vishnuprabu DMeta Gene