Gene: FGF12

2257
EIEE47|FGF12B|FHF1
fibroblast growth factor 12
protein-coding
3q28-q29
Ensembl:ENSG00000114279 MIM:601513 Vega:OTTHUMG00000156132 UniprotKB:P61328
NG_051966.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.989e-1 (AD)  7.475e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2062832chr3:192623262 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1922910chr3:192621072 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24637426chr3:192233231FGF12Gene body5.237e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRB20.973
KRT2220.973
KCNIP40.973
NEGR10.973
GABRA10.972
CNTNAP20.972
SNAP910.97
MAP7D20.97
PAK30.97
GABRG20.969

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.569
CNN2-0.533
SYDE1-0.532
RUNX3-0.518
TGIF1-0.516
HEY2-0.516
MAGEA12-0.515
CHST14-0.514
REST-0.513
RHOD-0.511

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF12 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of FGF12 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF12 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF12 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF12 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF12 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF12 mRNA"27188386
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF12 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FGF12 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FGF12 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGF12 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of FGF12 mRNA24449571
D001151ArsenicArsenic affects the expression of FGF12 protein24675094
C006632arsenic trioxidearsenic trioxide results in increased expression of FGF12 mRNA22521957
C015001arsenitearsenite results in increased methylation of FGF12 promoter23974009
D001280AtrazineAtrazine results in decreased expression of FGF12 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FGF12 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of FGF12 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FGF12 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FGF12 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FGF1220938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FGF12 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FGF12 mRNA20938992
D003042CocaineCocaine affects the expression of FGF12 mRNA20187946
D003976DiazinonDiazinon affects the expression of FGF12 mRNA19130878
D004026DieldrinDieldrin results in decreased expression of FGF12 mRNA19130878
D004041Dietary FatsDietary Fats results in decreased expression of FGF12 mRNA25016146
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF12 mRNA22129741
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FGF12 mRNA22079256
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FGF1220938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FGF12 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FGF12 mRNA20938992
D004397FonofosFonofos results in increased methylation of FGF12 promoter22847954
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF12 mRNA22129741
C011890kojic acidkojic acid results in increased expression of FGF12 mRNA16595896
D007854LeadLead affects the expression of FGF12 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of FGF1220938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of FGF12 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FGF12 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of FGF12 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FGF12 mRNA28001369
D008777MethyltestosteroneMethyltestosterone results in decreased expression of FGF12 mRNA29191790
D009151Mustard GasMustard Gas results in decreased expression of FGF12 mRNA15674843
D010278ParathionParathion results in increased methylation of FGF12 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF12 mRNA"25510870
D010656PhenylephrinePhenylephrine results in increased expression of FGF12 mRNA18158353
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FGF12 mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of FGF12 mRNA20345932
D010936Plant ExtractsPlant Extracts results in decreased expression of FGF12 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FGF12 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FGF12 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of FGF12 mRNA23608068
C017947sodium arsenitesodium arsenite affects the methylation of FGF12 gene28589171
C012568terbufosterbufos results in increased methylation of FGF12 promoter22847954
C009495titanium dioxidetitanium dioxide results in decreased expression of FGF12 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of FGF12 mRNA17045167
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF12 mRNA"27188386
D017974Uranium CompoundsUranium Compounds results in increased expression of FGF12 mRNA19654044
D014635Valproic AcidValproic Acid affects the expression of FGF12 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FGF12 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of FGF12 mRNA17292431
D015034Zinc OxideZinc Oxide analog results in decreased expression of FGF12 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0008083growth factor activity-IEA-  
GO:0017080sodium channel regulator activity-ISS12401812  
GO:0044325ion channel binding-ISS12401812  
GO ID GO Term Qualifier Evidence PubMed
GO:0003254regulation of membrane depolarization-IEA-  
GO:0007165signal transduction-TAS8790420  10049777  
GO:0007267cell-cell signaling-TAS8790420  10049777  
GO:0007268chemical synaptic transmission-IEA-  
GO:0007399nervous system development-TAS8790420  
GO:0007507heart development-TAS10049777  
GO:0008344adult locomotory behavior-IEA-  
GO:0008543fibroblast growth factor receptor signaling pathway-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010765positive regulation of sodium ion transport-IEA-  
GO:0050905neuromuscular process-IEA-  
GO:0086002cardiac muscle cell action potential involved in contraction-NAS12401812  
GO:0098908regulation of neuronal action potential-IMP27164707  
GO:1902305regulation of sodium ion transmembrane transport-ISS12401812  
GO:1905150regulation of voltage-gated sodium channel activity-IMP27164707  
GO:2000649regulation of sodium ion transmembrane transporter activity-ISS12401812  
GO:2001258negative regulation of cation channel activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS10049777  
GO:0005634nucleus-IDA8790420  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576892Phase 0 - rapid depolarisationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal