Gene: RRAS2

22800
TC21
RAS related 2
protein-coding
11p15.2
Ensembl:ENSG00000133818 MIM:600098 Vega:OTTHUMG00000165756 UniprotKB:P62070
NG_017058.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.747e-1 (AD)  4.073e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2349300chr11:14352116 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs11023186chr11:14321215 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11023182chr11:14297284 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MCMBP0.826
SH3GLB10.822
TMX10.813
SERP10.802
HAT10.793
PNPLA80.788
TGDS0.787
CPNE30.787
TMEM170A0.786
SMIM150.785

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.514
OR4F29-0.463
NKX6-3-0.28
PHOSPHO1-0.277
LRRC38-0.273
C2CD4D-0.271
ADRA1D-0.262
NPBWR2-0.261
LCN1-0.258
PLEKHD1-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0319031-UFT protocolRRAS2 protein results in decreased susceptibility to 1-UFT protocol16734730
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of RRAS2 mRNA"20406850
C0914232-chloromethylpyridine2-chloromethylpyridine results in increased expression of RRAS2 mRNA26198647
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of RRAS2 mRNA22841810
C0415944-nonylphenol4-nonylphenol results in increased expression of RRAS2 mRNA19000778
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of RRAS2 mRNA19000778
D000082AcetaminophenAcetaminophen affects the expression of RRAS2 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of RRAS2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RRAS2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of RRAS2 gene27153756
D000638AmiodaroneAmiodarone affects the expression of RRAS2 mRNA19483382
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of RRAS2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of RRAS2 protein25419056
D001280AtrazineAtrazine results in decreased expression of RRAS2 mRNA25929836
D001379AzathioprineAzathioprine results in increased expression of RRAS2 mRNA26198647
D001553BenzbromaroneBenzbromarone affects the expression of RRAS2 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RRAS2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RRAS2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RRAS2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RRAS2 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of RRAS2 mRNA19000778
C006780bisphenol Abisphenol A results in increased expression of RRAS2 mRNA19000778
C006780bisphenol Abisphenol A affects the expression of RRAS2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of RRAS2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of RRAS2 mRNA23410634
C584509C646 compoundC646 compound results in decreased expression of RRAS2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of RRAS2 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of RRAS2 promoter22457795
D000069287CapecitabineRRAS2 protein results in decreased susceptibility to Capecitabine16734730
D002220CarbamazepineCarbamazepine affects the expression of RRAS2 mRNA24752500|2597931
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of RRAS2 mRNA27339419
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of RRAS2 mRNA27344345
D002994ClofibrateClofibrate affects the expression of RRAS2 mRNA19483382
C018021cobaltous chloridecobaltous chloride results in increased expression of RRAS2 mRNA19376846
D003300CopperCopper results in increased expression of RRAS2 mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of RRAS2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of RRAS2 mRNA27523638
D003520CyclophosphamideCyclophosphamide results in increased expression of RRAS2 mRNA17403535
D016572CyclosporineCyclosporine results in decreased expression of RRAS2 mRNA27989131
D016572CyclosporineCyclosporine results in increased expression of RRAS2 mRNA25562108
C014347decitabinedecitabine affects the expression of RRAS2 mRNA23300844
D003907DexamethasoneDexamethasone results in increased expression of RRAS2 mRNA25047013
D003976DiazinonDiazinon results in increased expression of RRAS2 mRNA26198647
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RRAS2 mRNA17361019|2126653
D002945CisplatinCisplatin affects the expression of RRAS2 mRNA23300844
D004008DiclofenacDiclofenac affects the expression of RRAS2 mRNA24752500
C000944dicrotophosdicrotophos results in decreased expression of RRAS2 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of RRAS2 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of RRAS2 mRNA]19030233
C025034doxifluridineRRAS2 protein results in decreased susceptibility to doxifluridine16734730
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RRAS2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RRAS2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of RRAS2 mRNA28196854
D005001EthionineEthionine affects the expression of RRAS2 mRNA19483382
D005485FlutamideFlutamide results in decreased expression of RRAS2 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of RRAS2 mRNA22061828
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of RRAS2 mRNA23410634
C492448ICG 001ICG 001 results in decreased expression of RRAS2 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRAS2 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of RRAS2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of RRAS2 mRNA26254443
C410337K 7174K 7174 results in increased expression of RRAS2 mRNA24086573
D007649KetamineKetamine results in decreased expression of RRAS2 mRNA20080153
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RRAS2 mRNA"19285098
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of RRAS2 mRNA]12710931
D009151Mustard GasMustard Gas results in increased expression of RRAS2 mRNA18955075
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of RRAS2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RRAS2 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of RRAS2 mRNA18978301
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of RRAS2 mRNA27344345
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of RRAS2 mRNA19812364
C028007nickel monoxidenickel monoxide results in increased expression of RRAS2 mRNA19167457
C464660obeticholic acidobeticholic acid results in increased expression of RRAS2 mRNA27939613
D009853OmeprazoleOmeprazole affects the expression of RRAS2 mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of RRAS2 mRNA25729387
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of RRAS2 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of RRAS2 mRNA19429403
D010634PhenobarbitalPhenobarbital affects the expression of RRAS2 mRNA19159669
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of RRAS2 mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of RRAS2 mRNA19483382
D011441PropylthiouracilPropylthiouracil affects the expression of RRAS2 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of RRAS2 mRNA24780913
D011748PyrogallolPyrogallol results in increased expression of RRAS2 mRNA20362636
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of RRAS2 mRNA]19030233
D012834SilverSilver results in increased expression of RRAS2 mRNA26551752
C017947sodium arsenitesodium arsenite results in increased expression of RRAS2 mRNA17879257|2088654
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RRAS2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RRAS2 mRNA16214954
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RRAS2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RRAS2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RRAS2 mRNA15328365|1879615
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RRAS2 mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of RRAS2 mRNA19483382
C009495titanium dioxidetitanium dioxide results in decreased expression of RRAS2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of RRAS2 mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of RRAS2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of RRAS2 mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of RRAS2 mRNA19042947
C046488trimethyltintrimethyltin results in increased expression of RRAS2 mRNA20833246
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of RRAS2 mRNA]12710931
D014635Valproic AcidValproic Acid affects the expression of RRAS2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of RRAS2 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of RRAS2 mRNA17963808
C025643vinclozolinvinclozolin results in decreased expression of RRAS2 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of RRAS2 mRNA26682919
D024483Vitamin K 3Vitamin K 3 results in increased expression of RRAS2 mRNA23410634
C088658zoledronic acidzoledronic acid results in increased expression of RRAS2 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IEA-  
GO:0005515protein binding-IPI12620389  
GO:0005525GTP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001649osteoblast differentiation-HDA16210410  
GO:0007265Ras protein signal transduction-IEA-  
GO:0030335positive regulation of cell migration-IEA-  
GO:1901214regulation of neuron death-IMP21085126  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-NAS10777492  
GO:0005886plasma membrane-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0016020membrane-HDA16210410  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal