Gene: MYO16

23026
MYAP3|MYR8|Myo16b|NYAP3|PPP1R107
myosin XVI
protein-coding
13q33.3
Ensembl:ENSG00000041515 MIM:615479 UniprotKB:Q9Y6X6
NG_053147.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.548e-1 (AD)  1.473e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2181666chr13:109204497 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs919597chr13:109133497 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11616603chr13:108519067 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GRIN3A0.884
LHX60.881
ZNF385D0.872
MYO5B0.871
ADCY10.87
NRIP30.865
PCDHGC40.864
MAGI10.864
DCX0.858
ROBO20.856

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGIF1-0.55
RAB13-0.549
HEBP2-0.548
AGTRAP-0.547
ROM1-0.532
SNHG18-0.518
HVCN1-0.512
TRAF3IP2-0.507
PLIN2-0.507
ATOH8-0.504

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MYO16 mRNA"28973690
D000082AcetaminophenAcetaminophen results in decreased expression of MYO16 mRNA26690555
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MYO16 mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MYO16 mRNA19770486
C006780bisphenol Abisphenol A results in increased expression of MYO16 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of MYO16 mRNA24586524
C006780bisphenol Abisphenol A results in decreased expression of MYO16 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of MYO16 mRNA27178563
C018021cobaltous chloridecobaltous chloride results in decreased expression of MYO16 mRNA24386269
D016572CyclosporineCyclosporine results in decreased expression of MYO16 mRNA19770486
C029310lardlard results in increased expression of MYO16 mRNA26115784
D007854LeadLead affects the expression of MYO16 mRNA28903495
D015122MercaptopurineMercaptopurine results in increased expression of MYO16 mRNA23358152
D011374ProgesteroneProgesterone results in increased expression of MYO16 mRNA17404688
D011441PropylthiouracilPropylthiouracil results in increased expression of MYO16 mRNA24780913
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MYO16 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYO16 mRNA22298810
D014635Valproic AcidValproic Acid results in decreased methylation of MYO16 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MYO16 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003774motor activity-IEA-  
GO:0005524ATP binding-IEA-  
GO:0051015actin filament binding-ISS11588169  
GO ID GO Term Qualifier Evidence PubMed
GO:0008285negative regulation of cell proliferation-ISS17029291  
GO:0021549cerebellum development-ISS11588169  
GO:2000134negative regulation of G1/S transition of mitotic cell cycle-ISS17029291  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA17029291  
GO:0005737cytoplasm-ISS11588169  
GO:0005886plasma membrane-ISS11588169  17029291  
GO:0016459myosin complex-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA17029291  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal