Gene: TBC1D2B

23102
-
TBC1 domain family member 2B
protein-coding
15q24.3-q25.1
Ensembl:ENSG00000167202 Vega:OTTHUMG00000152885 UniprotKB:Q9UPU7
NC_000015.10
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.539e-1 (AD)  3.543e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12148365chr15:78057008 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs4886554chr15:78052580 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20059377chr15:78369232TBC1D2B1.100e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CYFIP10.83
SORBS10.82
LAMC10.817
GNS0.805
SLC25A370.802
AFF10.798
TEP10.796
IGF2R0.796
MOB1A0.796
MALT10.793

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.424
OR4F29-0.402
CRH-0.358
MUC12-0.313
MYCNOS-0.25
NKX2-8-0.237
TMEM114-0.237
LYPD8-0.233
GHRH-0.232
C1orf53-0.231

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of TBC1D2B mRNA"20816883
D000082AcetaminophenAcetaminophen results in decreased expression of TBC1D2B mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of TBC1D2B mRNA22230336
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TBC1D2B mRNA"23195993
D001151ArsenicArsenic affects the methylation of TBC1D2B gene25304211
D001554BenzeneBenzene results in increased expression of TBC1D2B mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBC1D2B mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TBC1D2B mRNA22228805
C044887beta-methylcholinebeta-methylcholine affects the expression of TBC1D2B mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of TBC1D2B mRNA25047013
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D2B mRNA28628672
C006780bisphenol Abisphenol A affects the expression of TBC1D2B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TBC1D2B gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TBC1D2B mRNA17484886
D016572CyclosporineCyclosporine results in decreased expression of TBC1D2B mRNA20106945
D016572CyclosporineCyclosporine results in increased methylation of TBC1D2B promoter27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D2B mRNA28628672
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of TBC1D2B mRNA15576828
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TBC1D2B mRNA23649840
D005485FlutamideFlutamide results in decreased expression of TBC1D2B mRNA24136188
C004312glycidolglycidol results in increased expression of TBC1D2B mRNA24915197
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D2B mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBC1D2B mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TBC1D2B mRNA28628672
C544151jinfukangjinfukang results in increased expression of TBC1D2B mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TBC1D2B mRNA23649840
D009532NickelNickel results in decreased expression of TBC1D2B mRNA23195993
C016030pantogabpantogab results in decreased expression of TBC1D2B mRNA17379144
D010634PhenobarbitalPhenobarbital affects the expression of TBC1D2B mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of TBC1D2B mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of TBC1D2B mRNA20813756|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of TBC1D2B mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TBC1D2B mRNA22714537
C045950propiconazolepropiconazole results in decreased expression of TBC1D2B mRNA21278054
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of TBC1D2B mRNA21427059
D012834SilverSilver results in increased expression of TBC1D2B mRNA27131904
D012999SomanSoman results in decreased expression of TBC1D2B mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBC1D2B mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBC1D2B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBC1D2B mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TBC1D2B mRNA25613284
C057693troglitazonetroglitazone results in decreased expression of TBC1D2B mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of TBC1D2B mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of TBC1D2B gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TBC1D2B mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of TBC1D2B mRNA19136453|2142705
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TBC1D2B gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of TBC1D2B mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IBA21873635  
GO:0005515protein binding-IPI20562859  22354992  
GO:0017137Rab GTPase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0090630activation of GTPase activity-IBA21873635  
GO:1902017regulation of cilium assemblyNOTIMP17646400  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal