Gene: NAALADL2

254827
-
N-acetylated alpha-linked acidic dipeptidase like 2
protein-coding
3q26.31
Ensembl:ENSG00000177694 MIM:608806 Vega:OTTHUMG00000157120 UniprotKB:Q58DX5
NC_000003.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.871e-3 (AD)  7.096e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs58398985chr3:175318979-175318983 (GRCh38.p7)dupTalcohol dependenceIndel(Insertion and Deletion)
rs10513729chr3:174963457 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SSPN0.634
MBNL30.632
ANTXR10.62
AASS0.618
PARD3B0.617
HEATR5A0.612
CTSO0.611
SPATA60.609
SS180.602
SNTB10.598

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNB1L-0.377
CHAC1-0.373
TUBA8-0.367
SHH-0.357
SCRT2-0.351
MARCH11-0.347
SSTR3-0.345
CA7-0.345
TNFRSF18-0.342
RHO-0.339

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of NAALADL2 mRNA"21920950
C547126AZM551248AZM551248 results in decreased expression of NAALADL2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NAALADL2 mRNA23735875
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of NAALADL2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of NAALADL2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of NAALADL2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of NAALADL2 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of NAALADL2 mRNA25270620
C024565ethylene dichlorideethylene dichloride results in decreased expression of NAALADL2 mRNA28189721
C039281furanfuran results in decreased expression of NAALADL2 mRNA25539665
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NAALADL2 mRNA26752646
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of NAALADL2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NAALADL2 mRNA"25554681|2562005
D010936Plant ExtractsPlant Extracts results in decreased expression of NAALADL2 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of NAALADL2 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in decreased expression of NAALADL2 mRNA24780913
C116926rofecoxibrofecoxib results in decreased expression of NAALADL2 mRNA17070997
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of NAALADL2 mRNA26496021
D014635Valproic AcidValproic Acid results in increased methylation of NAALADL2 gene28853863

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal