Gene info: ID 25937

Gene: WWTR1

GENE ID: 25937

Synonyms: TAZ

Description: WW domain containing transcription regulator 1

Gene type: protein-coding

Location: 3q25.1

dbXrefs: Ensembl:ENSG00000018408 MIM:607392 Vega:OTTHUMG00000159614 UniprotKB:Q9GZV5

RefSeq: NC_000003.12

Retrived from: PubMed|SNP Mapped

SNPs: 4 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.216e-1 (AD) 3.975e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs7638140	chr3:149629784 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs6790596	chr3:149629260 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs9857773	chr3:149626828 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs1344815	chr3:149623026 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TAGLN2	0.875
ANO6	0.874
MSN	0.873
DRAM1	0.872
ANXA2	0.87
ELK3	0.87
KIAA0040	0.864
BAZ1A	0.862
CLIC1	0.859
IFI16	0.859

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABCC12	-0.68
KCNB2	-0.678
NEUROD6	-0.673
CALHM1	-0.67
LRTM2	-0.667
BCL11A	-0.66
SLC7A4	-0.658
MARCH4	-0.656
MYADML2	-0.652
EXTL1	-0.648

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C075773	4-phenylbutyric acid	4-phenylbutyric acid results in decreased expression of WWTR1 mRNA	14583596
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of WWTR1 mRNA	26690555
D000082	Acetaminophen	Acetaminophen results in increased expression of WWTR1 mRNA	21420995\|2223033
D000082	Acetaminophen	Acetaminophen affects the expression of WWTR1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of WWTR1 gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of WWTR1 mRNA	19770486
D001151	Arsenic	Arsenic affects the methylation of WWTR1 gene	25304211
D001151	Arsenic	Arsenic results in increased expression of WWTR1 protein	23942117
C006632	arsenic trioxide	arsenic trioxide results in increased expression of WWTR1 mRNA	22521957
D001205	Ascorbic Acid	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of WWTR1 mRNA	17639512
D001374	Azacitidine	Azacitidine results in increased expression of WWTR1 mRNA	20823114
C487081	belinostat	belinostat results in decreased degradation of and results in increased stability of and results in increased expression of WWTR1 protein	23671600
C487081	belinostat	pyrvinium inhibits the reaction [belinostat results in increased expression of WWTR1 protein]	23671600
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of WWTR1 mRNA	21632981\|2623829
D004958	Estradiol	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of WWTR1 mRNA	20823114
C006780	bisphenol A	bisphenol A affects the expression of WWTR1 mRNA	21786754
C584509	C646 compound	C646 compound results in decreased expression of WWTR1 mRNA	26191083
D002220	Carbamazepine	Carbamazepine affects the expression of WWTR1 mRNA	25979313
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of WWTR1 mRNA	26272509
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WWTR1 gene	20938992
D002922	Ciguatoxins	Ciguatoxins affects the expression of WWTR1 mRNA	18353800
D002994	Clofibrate	Clofibrate results in increased expression of WWTR1 mRNA	25270620
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of WWTR1 mRNA	19320972
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of WWTR1 mRNA	20971185
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of WWTR1 mRNA	15467011
D003471	Cuprizone	Cuprizone results in increased expression of WWTR1 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of WWTR1 mRNA	25562108\|2798913
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of WWTR1 mRNA	21266533
D003994	Bucladesine	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of WWTR1 mRNA	20823114
C000944	dicrotophos	dicrotophos results in increased expression of WWTR1 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in increased expression of WWTR1 mRNA	19030233
D004041	Dietary Fats	rimonabant inhibits the reaction [Dietary Fats results in increased expression of WWTR1 mRNA]	19030233
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of WWTR1 mRNA	23649840
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WWTR1 gene	20938992
D004397	Fonofos	Fonofos results in increased methylation of WWTR1 promoter	22847954
D005557	Formaldehyde	Formaldehyde results in increased expression of WWTR1 mRNA	23649840
C039281	furan	furan results in increased expression of WWTR1 mRNA	25539665
C000588695	IBS008738	IBS008738 affects the expression of WWTR1 protein modified form	24550007
C000588695	IBS008738	IBS008738 results in increased stability of WWTR1 protein	24550007
C000588695	IBS008738	IBS008738 promotes the reaction [WWTR1 protein binds to MYOD1 protein]	24550007
C000588695	IBS008738	WWTR1 results in increased susceptibility to IBS008738	24550007
D017258	Medroxyprogesterone Acetate	[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of WWTR1 mRNA	20823114
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of WWTR1 gene	20938992
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of WWTR1 mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of WWTR1 mRNA	23179753\|2800136
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of WWTR1 mRNA	23649840
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of WWTR1 mRNA"	20188158
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of WWTR1 mRNA"	25620056
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of WWTR1 mRNA	20971185
D010278	Parathion	Parathion results in increased methylation of WWTR1 promoter	22847954
D010634	Phenobarbital	Phenobarbital affects the expression of WWTR1 mRNA	19159669
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of WWTR1 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of WWTR1 mRNA	19482888
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of WWTR1 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of WWTR1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of WWTR1 mRNA	18301758\|2381119
D010938	Plant Oils	Plant Oils results in increased expression of WWTR1 mRNA	23370395
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of WWTR1 mRNA	27029645
C024631	pyrvinium	pyrvinium inhibits the reaction [belinostat results in increased expression of WWTR1 protein]	23671600
D011794	Quercetin	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of WWTR1 mRNA	17639512
D011794	Quercetin	Quercetin results in increased expression of WWTR1 mRNA	21632981
C089032	rimonabant	rimonabant inhibits the reaction [Dietary Fats results in increased expression of WWTR1 mRNA]	19030233
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of WWTR1 mRNA	25351596
D012999	Soman	Soman results in increased expression of WWTR1 mRNA	19281266
C012568	terbufos	terbufos results in increased methylation of WWTR1 promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of WWTR1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of WWTR1 mRNA	22298810
C009495	titanium dioxide	titanium dioxide results in decreased expression of WWTR1 mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of WWTR1 mRNA	23409001
D014212	Tretinoin	Tretinoin results in increased expression of WWTR1 mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of WWTR1 mRNA	24935251\|2627250
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of WWTR1 mRNA"	26179874
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of WWTR1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of WWTR1 mRNA	23179753\|2627250
C551177	vemurafenib	vemurafenib affects the localization of WWTR1 protein	26668268
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of WWTR1 mRNA	25270620
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WWTR1 mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of WWTR1 mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003713	transcription coactivator activity	-	IDA	19010321
GO:0003713	transcription coactivator activity	-	NAS	11118213
GO:0003714	transcription corepressor activity	-	IEA	-
GO:0005515	protein binding	-	IPI	11118213 16099986 16189514 18227151 18568018 19010321 19324877 20412773 20594350 20936779 20972459 22078877 22234184 23245942
GO:0042803	protein homodimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0001649	osteoblast differentiation	-	IEA	-
GO:0001894	tissue homeostasis	-	IEA	-
GO:0001933	negative regulation of protein phosphorylation	-	IMP	20412773
GO:0003015	heart process	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	NAS	11118213
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0006469	negative regulation of protein kinase activity	-	IMP	20412773
GO:0008284	positive regulation of cell proliferation	-	IDA	18227151
GO:0010718	positive regulation of epithelial to mesenchymal transition	-	IDA	18227151
GO:0016567	protein ubiquitination	-	IEA	-
GO:0017145	stem cell division	-	IDA	18568018
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	IEA	-
GO:0032835	glomerulus development	-	IEA	-
GO:0035264	multicellular organism growth	-	IEA	-
GO:0035329	hippo signaling	-	IDA	18227151 20412773
GO:0035329	hippo signaling	-	TAS	-
GO:0045599	negative regulation of fat cell differentiation	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	TAS	-
GO:0048762	mesenchymal cell differentiation	-	IEA	-
GO:0060271	cilium assembly	-	IEA	-
GO:0060390	regulation of SMAD protein signal transduction	-	IDA	18568018
GO:0060993	kidney morphogenesis	-	IEA	-
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	-	IEA	-
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	IMP	20412773

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	18568018
GO:0005634	nucleus	-	NAS	11118213
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IEA	-
GO:0005737	cytoplasm	-	IDA	20412773
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0016604	nuclear body	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-170834	Signaling by TGF-beta Receptor Complex	TAS
R-HSA-2028269	Signaling by Hippo	TAS
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	IEA
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	TAS
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	TAS
R-HSA-397014	Muscle contraction	TAS
R-HSA-5576891	Cardiac conduction	TAS
R-HSA-5578768	Physiological factors	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-8878159	Transcriptional regulation by RUNX3	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8940973	RUNX2 regulates osteoblast differentiation	IEA
R-HSA-8941326	RUNX2 regulates bone development	IEA
R-HSA-8951671	RUNX3 regulates YAP1-mediated transcription	TAS
R-HSA-9006936	Signaling by TGF-beta family members	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27628948	The Emerging Role of the Hippo Pathway in Lung Cancers: Clinical Implications. (2017 Nov 30)	Teoh SL	Curr Drug Targets
27602958	Epigenome-wide association study of smoking and DNA methylation in non-small cell lung neoplasms. (2016 Oct 25)	Freeman JR	Oncotarget
21071578	A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. (2011 Jan)	Balasenthil S	Cancer Prev Res (Phila)