Gene: GPR137C

283554
TM7SF1L2
G protein-coupled receptor 137C
protein-coding
14q22.1
Ensembl:ENSG00000180998 Vega:OTTHUMG00000171104 UniprotKB:Q8N3F9
NC_000014.9
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.499e-1 (AD)  7.171e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1007894chr14:52627877 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4901286chr14:52579883 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
JAZF10.935
DNAJC60.934
PRPS20.93
ATP6V1A0.929
INPP5F0.929
CD2000.928
CADPS0.927
NELL20.927
NEGR10.925
GLRB0.924

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.479
RHOD-0.467
RNF135-0.454
ASB4-0.451
SYDE1-0.446
CHST14-0.443
AJUBA-0.44
GJB2-0.439
MTRNR2L10-0.434
FZD10-0.431

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPR137C mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPR137C mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPR137C mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPR137C mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPR137C mRNA"25510870
D000082AcetaminophenAcetaminophen affects the expression of GPR137C mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of GPR137C mRNA22230336|2906747
D020106AcrylamideAcrylamide results in decreased expression of GPR137C mRNA28959563
D000638AmiodaroneAmiodarone affects the expression of GPR137C mRNA25064622
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GPR137C mRNA21632981
C006780bisphenol Abisphenol A results in decreased expression of GPR137C mRNA25181051
D002746ChlorpromazineChlorpromazine affects the expression of GPR137C mRNA25064622
D019327Copper SulfateCopper Sulfate results in increased expression of GPR137C mRNA19549813
D016572CyclosporineCyclosporine affects the expression of GPR137C mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GPR137C mRNA25064622
D005472FluorouracilFluorouracil affects the expression of GPR137C mRNA16584549
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of GPR137C mRNA27440272
C045463leflunomideleflunomide results in increased expression of GPR137C mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GPR137C mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GPR137C mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GPR137C mRNA"26251327
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of GPR137C mRNA"23246600
D010269ParaquatParaquat affects the expression of GPR137C mRNA25064622
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GPR137C mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of GPR137C mRNA26705709
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GPR137C mRNA22714537
D012834SilverSilver results in increased expression of GPR137C mRNA26014281
C017947sodium arsenitesodium arsenite affects the expression of GPR137C mRNA29319823
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GPR137C mRNA28922406
D013752TetracyclineTetracycline affects the expression of GPR137C mRNA25064622
D013806TheophyllineTheophylline results in increased expression of GPR137C mRNA18951874
D013853ThioacetamideThioacetamide affects the expression of GPR137C mRNA25064622
C012589trichostatin Atrichostatin A results in increased expression of GPR137C mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GPR137C mRNA"26743178
D014635Valproic AcidValproic Acid affects the expression of GPR137C mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of GPR137C mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GPR137C mRNA24935251|2915479
D014638VanadatesVanadates results in increased expression of GPR137C mRNA22714537
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in decreased expression of GPR137C mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal