Gene: GRM7

2917
GLUR7|GPRC1G|MGLU7|MGLUR7|PPP1R87
glutamate metabotropic receptor 7
protein-coding
3p26.1
Ensembl:ENSG00000196277 MIM:604101 Vega:OTTHUMG00000125549 UniprotKB:Q14831
NG_029781.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.437e-1 (AD)  4.715e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1485179chr3:7562021 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1868616chr3:7463800 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH80.926
LRFN50.926
SLIT20.925
GABRG20.923
HTR2A0.923
NEGR10.922
OLFM30.922
NTNG10.921
PARM10.921
SCN2A0.92

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.58
REST-0.57
RAI14-0.564
YES1-0.543
COPZ2-0.541
MBNL3-0.523
CSAG1-0.513
CHST14-0.513
FAM114A1-0.511
ROM1-0.504

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRM7 mRNA"19114083
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GRM7 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRM7 mRNA16483693
C015001arsenitearsenite results in increased methylation of GRM7 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of GRM7 mRNA"17331233
D001280AtrazineAtrazine results in increased expression of GRM7 mRNA25929836
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GRM7 mRNA18164116
C006780bisphenol Abisphenol A results in increased methylation of GRM7 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of GRM7 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of GRM7 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of GRM7 gene28505145
D004390ChlorpyrifosChlorpyrifos results in increased expression of GRM7 mRNA17452286
D003042CocaineCocaine results in increased expression of GRM7 mRNA16076954
D003471CuprizoneCuprizone results in decreased expression of GRM7 mRNA26577399
D003976DiazinonDiazinon results in increased expression of GRM7 mRNA17452286
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GRM7 mRNA15620428
D004008DiclofenacDiclofenac results in increased expression of GRM7 mRNA26934552
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of GRM7 mRNA15620428
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GRM7 mRNA18164116
D000431EthanolEthanol results in increased expression of GRM7 mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GRM7 mRNA29097150
D004397FonofosFonofos results in increased methylation of GRM7 promoter22847954
C002385linsidominelinsidomine results in increased oxidation of GRM7 protein28086193
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GRM7 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GRM7 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of GRM7 mRNA12710931
C507346N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride"N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride results in increased activity of GRM7 protein"19940105
D010278ParathionParathion results in increased methylation of GRM7 promoter22847954
D010936Plant ExtractsPlant Extracts results in decreased expression of GRM7 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of GRM7 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of GRM7 mRNA23012394
D012402RotenoneGRM7 protein results in decreased susceptibility to Rotenone16624952
C017947sodium arsenitesodium arsenite results in increased methylation of GRM7 gene24118411
D013654TaurineTaurine results in decreased expression of GRM7 mRNA16579726
C012568terbufosterbufos results in increased methylation of GRM7 promoter22847954
D014050TolueneToluene affects the expression of GRM7 mRNA21827849
D014635Valproic AcidValproic Acid results in decreased methylation of GRM7 gene29154799
D014635Valproic AcidValproic Acid affects the expression of GRM7 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001642group III metabotropic glutamate receptor activity-IBA21873635  
GO:0001642group III metabotropic glutamate receptor activity-IDA9144652  9473604  
GO:0005246calcium channel regulator activity-IBA21873635  
GO:0008066glutamate receptor activity-IBA21873635  
GO:0008066glutamate receptor activity-IDA9473604  
GO:0010855adenylate cyclase inhibitor activity-IDA9473604  
GO:0070905serine binding-IDA9144652  
GO ID GO Term Qualifier Evidence PubMed
GO:0001662behavioral fear responseNOTIMP17167337  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway-IDA9473604  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007268chemical synaptic transmission-IDA9473604  
GO:0007605sensory perception of sound-IMP19047183  
GO:0014050negative regulation of glutamate secretion-ISS-  
GO:0031279regulation of cyclase activity-IEA-  
GO:0051966regulation of synaptic transmission, glutamatergic-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-NAS9473604  
GO:0005938cell cortex-IDA9630572  
GO:0016021integral component of membrane-IDA12746871  
GO:0030424axon-ISS-  
GO:0030425dendrite-IDA9630572  
GO:0032279asymmetric synapse-ISS-  
GO:0042734presynaptic membrane-IBA21873635  
GO:0043198dendritic shaft-ISS-  
GO:0043235receptor complex-IDA23382219  
GO:0045211postsynaptic membrane-ISS-  
GO:0048786presynaptic active zone-ISS-  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)TAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27711239Hemizygous Deletion on Chromosome 3p26.1 Is Associated with Heavy Smoking among African American Subjects in the COPDGene Study. (2016)Begum FPLoS One
21920414Disease-driven detection of differential inherited SNP modules from SNP network. (2011 Dec 10)Li CGene
17936574Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking. (2007 Dec)Vadasz CGenomics
25939814CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. (2015 Aug)Chen JHum Brain Mapp