Gene: GRM8

2918
GLUR8|GPRC1H|MGLUR8|mGlu8
glutamate metabotropic receptor 8
protein-coding
7q31.33
Ensembl:ENSG00000179603 MIM:601116 Vega:OTTHUMG00000022888 UniprotKB:O00222
NG_029532.1
PubMed|SNP Mapped
2   ANCO-SNPs
OD|ND|AD
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.829e-1 (AD)  3.510e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2237781chr7:127034996 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs10256873chr7:126728238 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NELL10.9
OSBPL100.895
FAM102B0.89
HECW10.89
ERC20.889
CLSTN20.888
CNIH30.888
OPCML0.888
STXBP5L0.885
ZNF385B0.884

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.594
HVCN1-0.578
STON2-0.578
HEY2-0.574
ROM1-0.565
YES1-0.564
AKR1C3-0.562
TMEM176A-0.556
IMPA2-0.556
MYOM1-0.555

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C5234151-amino-2-phosphonomethylcyclopropanecarboxylic acid1-amino-2-phosphonomethylcyclopropanecarboxylic acid analog binds to GRM8 protein17602546
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRM8 mRNA"19114083
C0127292-amino-4-phosphonobutyric acid2-amino-4-phosphonobutyric acid binds to GRM8 protein17602546
C1107333,4-dicarboxyphenylglycine"3,4-dicarboxyphenylglycine binds to and results in increased activity of GRM8 protein"17430409|1743446
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GRM8 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRM8 mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of GRM8 mRNA18255232
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of GRM8 mRNA"17331233
D001280AtrazineAtrazine results in decreased expression of GRM8 mRNA22378314
C452139BIRB 796BIRB 796 results in increased expression of GRM8 mRNA24303162
C006780bisphenol Abisphenol A results in decreased expression of GRM8 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GRM8 gene28505145
D002104CadmiumCadmium results in decreased expression of GRM8 mRNA21120746
D016572CyclosporineCyclosporine results in increased methylation of GRM8 promoter27989131
D003976DiazinonDiazinon results in decreased expression of GRM8 mRNA17452286
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GRM8 mRNA15620428
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GRM8 mRNA24535843
D000431EthanolEthanol results in decreased expression of GRM8 mRNA20655511
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GRM8 gene16495775
C008261lead acetatelead acetate results in increased expression of GRM8 mRNA24260418
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of GRM8 mRNA24535843
D010634PhenobarbitalPhenobarbital results in increased expression of GRM8 mRNA19482888
D010862PilocarpinePilocarpine results in decreased expression of GRM812539201
D010862PilocarpinePilocarpine results in increased expression of GRM8 protein11226630
D010936Plant ExtractsPlant Extracts results in decreased expression of GRM8 mRNA23557933
D011374ProgesteroneProgesterone results in decreased expression of GRM8 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of GRM8 mRNA24780913
C502851quinocetonequinocetone results in decreased expression of GRM8 mRNA27046791
D012402RotenoneGRM8 protein results in decreased susceptibility to Rotenone16624952
C017947sodium arsenitesodium arsenite affects the methylation of GRM8 gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GRM8 mRNA28922406
D013793Thallium[GRM8 protein results in increased activity of [KCNJ3 protein binds to KCNJ6 protein]] which results in increased transport of Thallium22275899
D014212TretinoinTretinoin results in decreased expression of GRM8 mRNA23724009
D014635Valproic AcidValproic Acid results in decreased methylation of GRM8 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of GRM8 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased expression of GRM8 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GRM8 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of GRM8 mRNA"24525044
C088658zoledronic acidzoledronic acid results in decreased expression of GRM8 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001642group III metabotropic glutamate receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IMP9473604  
GO:0008066glutamate receptor activity-IBA21873635  
GO:0008066glutamate receptor activity-IMP9473604  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IDA11166323  
GO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway-IMP9473604  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007601visual perception-TAS9473604  
GO:0051966regulation of synaptic transmission, glutamatergic-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS9473604  
GO:0042734presynaptic membrane-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)TAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19268276Genome-wide association study of smoking initiation and current smoking. (2009 Mar)Vink JMAm J Hum Genet
18618593Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. (2009 Apr 5)Chen ACAm J Med Genet B Neuropsychiatr Genet
20560679Response to methadone maintenance treatment is associated with the MYOCD and GRM6 genes. (2010 Jun 1)Fonseca FMol Diagn Ther
25978827Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults. (2015 May)Long ECJ Stud Alcohol Drugs
18634760Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes. (2008 Oct 15)Rangaswamy MBrain Res
24392270The role of rs2237781 within GRM8 in eating behavior. (2013 Sep)Gast MTBrain Behav