Gene info: ID 3269

Gene: HRH1

GENE ID: 3269

Synonyms: H1-R|H1R|HH1R|hisH1

Description: histamine receptor H1

Gene type: protein-coding

Location: 3p25.3

dbXrefs: Ensembl:ENSG00000196639 MIM:600167 Vega:OTTHUMG00000129719 UniprotKB:P35367

RefSeq: NC_000003.12

Retrived from: PubMed|SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.218e-4 (AD) 4.099e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs443137	chr3:11212035 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs433303	chr3:11203220 (GRCh38.p7)	C>G / C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs9822871	chr3:11197680 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SPRED2	0.803
CHST10	0.701
ZBTB21	0.7
CLDN12	0.697
TRAF3	0.696
ZDHHC5	0.696
EFNB2	0.695
SHROOM3	0.694
PLXNA1	0.694
FLRT2	0.69

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.45
C5orf64	-0.442
SH2D1A	-0.439
CTNNA3	-0.438
SLCO1A2	-0.427
POU2AF1	-0.4
TRPV5	-0.397
TNFRSF13B	-0.396
BTBD16	-0.396
ZFP57	-0.388

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00215	Citalopram	Small Molecule	59729-33-8	Approved	Target
DB00245	Benzatropine	Small Molecule	86-13-5	Approved	Target
DB00246	Ziprasidone	Small Molecule	146939-27-7	Approved	Target
DB00283	Clemastine	Small Molecule	15686-51-8	Approved\|Investigational	Target
DB00321	Amitriptyline	Small Molecule	50-48-6	Approved	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00341	Cetirizine	Small Molecule	83881-51-0	Approved	Target
DB00342	Terfenadine	Small Molecule	50679-08-8	Approved\|Withdrawn	Target
DB00354	Buclizine	Small Molecule	82-95-1	Approved	Target
DB00363	Clozapine	Small Molecule	5786-21-0	Approved	Target
DB00366	Doxylamine	Small Molecule	469-21-6	Approved	Target
DB00370	Mirtazapine	Small Molecule	85650-52-8	Approved	Target
DB00405	Dexbrompheniramine	Small Molecule	132-21-8	Approved	Target
DB00408	Loxapine	Small Molecule	1977-10-2	Approved	Target
DB00420	Promazine	Small Molecule	58-40-2	Approved	Target
DB00427	Triprolidine	Small Molecule	486-12-4	Approved	Target
DB00434	Cyproheptadine	Small Molecule	129-03-3	Approved	Target
DB00455	Loratadine	Small Molecule	79794-75-5	Approved\|Investigational	Target
DB00458	Imipramine	Small Molecule	50-49-7	Approved	Target
DB00477	Chlorpromazine	Small Molecule	50-53-3	Approved\|Investigational	Target
DB00540	Nortriptyline	Small Molecule	72-69-5	Approved	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB00557	Hydroxyzine	Small Molecule	68-88-2	Approved	Target
DB00568	Cinnarizine	Small Molecule	298-57-7	Approved\|Investigational	Target
DB00637	Astemizole	Small Molecule	68844-77-9	Approved\|Withdrawn	Target
DB00656	Trazodone	Small Molecule	19794-93-5	Approved\|Investigational	Target
DB00719	Azatadine	Small Molecule	3964-81-6	Approved	Target
DB00726	Trimipramine	Small Molecule	739-71-9	Approved	Target
DB00734	Risperidone	Small Molecule	106266-06-2	Approved\|Investigational	Target
DB00737	Meclizine	Small Molecule	569-65-3	Approved	Target
DB00748	Carbinoxamine	Small Molecule	486-16-8	Approved	Target
DB00751	Epinastine	Small Molecule	80012-43-7	Approved\|Investigational	Target
DB00767	Benzquinamide	Small Molecule	63-12-7	Withdrawn	Target
DB00768	Olopatadine	Small Molecule	113806-05-6	Approved	Target
DB00777	Propiomazine	Small Molecule	362-29-8	Approved	Target
DB00792	Tripelennamine	Small Molecule	91-81-6	Approved	Target
DB00797	Tolazoline	Small Molecule	59-98-3	Approved	Target
DB00835	Brompheniramine	Small Molecule	86-22-6	Approved	Target
DB00902	Methdilazine	Small Molecule	1982-37-2	Approved	Target
DB00920	Ketotifen	Small Molecule	34580-13-7	Approved	Target
DB00934	Maprotiline	Small Molecule	10262-69-8	Approved\|Investigational	Target
DB00950	Fexofenadine	Small Molecule	83799-24-0	Approved\|Investigational	Target
DB00967	Desloratadine	Small Molecule	100643-71-8	Approved\|Investigational	Target
DB00972	Azelastine	Small Molecule	58581-89-8	Approved	Target
DB00985	Dimenhydrinate	Small Molecule	523-87-5	Approved	Target
DB01069	Promethazine	Small Molecule	60-87-7	Approved\|Investigational	Target
DB01071	Mequitazine	Small Molecule	29216-28-2	Approved	Target
DB01075	Diphenhydramine	Small Molecule	58-73-1	Approved\|Investigational	Target
DB01084	Emedastine	Small Molecule	87233-61-2	Approved	Target
DB01106	Levocabastine	Small Molecule	79516-68-0	Approved\|Investigational	Target
DB01114	Chlorphenamine	Small Molecule	132-22-9	Approved	Target
DB01142	Doxepin	Small Molecule	1668-19-5	Approved\|Investigational	Target
DB01146	Diphenylpyraline	Small Molecule	147-20-6	Approved\|Investigational	Target
DB01151	Desipramine	Small Molecule	50-47-5	Approved\|Investigational	Target
DB01173	Orphenadrine	Small Molecule	83-98-7	Approved	Target
DB01175	Escitalopram	Small Molecule	128196-01-0	Approved\|Investigational	Target
DB01176	Cyclizine	Small Molecule	82-92-8	Approved	Target
DB01224	Quetiapine	Small Molecule	111974-69-7	Approved	Target
DB01237	Bromodiphenhydramine	Small Molecule	118-23-0	Approved	Target
DB01238	Aripiprazole	Small Molecule	129722-12-9	Approved\|Investigational	Target
DB01239	Chlorprothixene	Small Molecule	113-59-7	Approved\|Investigational\|Withdrawn	Target
DB01246	Alimemazine	Small Molecule	84-96-8	Approved	Target
DB01267	Paliperidone	Small Molecule	144598-75-4	Approved	Target
DB01403	Methotrimeprazine	Small Molecule	60-99-1	Approved\|Investigational	Target
DB01615	Aceprometazine	Small Molecule	13461-01-3	Approved	Target
DB01619	Phenindamine	Small Molecule	82-88-2	Approved	Target
DB01620	Pheniramine	Small Molecule	86-21-5	Approved	Target
DB01624	Zuclopenthixol	Small Molecule	53772-83-1	Approved\|Investigational	Target
DB04837	Clofedanol	Small Molecule	791-35-5	Approved\|Withdrawn	Target
DB04841	Flunarizine	Small Molecule	52468-60-7	Approved	Target
DB04890	Bepotastine	Small Molecule	125602-71-3	Approved	Target
DB04905	Tesmilifene	Small Molecule	98774-23-3	Investigational	Target
DB04946	Iloperidone	Small Molecule	133454-47-4	Approved	Target
DB05079	HY10275	Small Molecule	-	Investigational	Target
DB05080	OBE101	Small Molecule	-	Investigational	Target
DB05345	SO-101	Small Molecule	-	Investigational	Target
DB05381	Histamine	Small Molecule	51-45-6	Approved\|Investigational	Target
DB05492	Epicept NP-1	Small Molecule	-	Investigational	Target
DB06016	Cariprazine	Small Molecule	839712-12-8	Approved\|Investigational	Target
DB06148	Mianserin	Small Molecule	24219-97-4	Approved\|Investigational	Target
DB06216	Asenapine	Small Molecule	65576-45-6	Approved	Target
DB06229	Ocaperidone	Small Molecule	129029-23-8	Investigational	Target
DB06282	Levocetirizine	Small Molecule	130018-77-8	Approved	Target
DB06678	Esmirtazapine	Small Molecule	61337-87-9	Investigational	Target
DB06691	Mepyramine	Small Molecule	91-84-9	Approved	Target
DB06698	Betahistine	Small Molecule	5638-76-6	Approved\|Investigational	Target
DB06766	Alcaftadine	Small Molecule	147084-10-4	Approved	Target
DB08799	Antazoline	Small Molecule	91-75-8	Approved	Target
DB08800	Chloropyramine	Small Molecule	59-32-5	Approved	Target
DB08801	Dimetindene	Small Molecule	5636-83-9	Approved\|Investigational	Target
DB08802	Isothipendyl	Small Molecule	482-15-5	Approved	Target
DB08922	Perospirone	Small Molecule	150915-41-6	Approved	Target
DB08936	Chlorcyclizine	Small Molecule	82-93-9	Approved	Target
DB09016	Butriptyline	Small Molecule	35941-65-2	Approved	Target
DB09167	Dosulepin	Small Molecule	113-53-1	Approved	Target
DB09194	Etoperidone	Small Molecule	52942-31-1	Withdrawn	Target
DB09195	Lorpiprazole	Small Molecule	108785-69-9	Approved	Target
DB09488	Acrivastine	Small Molecule	87848-99-5	Approved	Target
DB09555	Dexchlorpheniramine maleate	Small Molecule		Approved	Target
DB11591	Bilastine	Small Molecule	202189-78-4	Approved\|Investigational	Target
DB11614	Rupatadine	Small Molecule	158876-82-5	Approved	Target
DB13025	Tiapride	Small Molecule	51012-32-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein]"	18508907
C084981	1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene	"1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein"	10661506
C084981	1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene	"[1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein] promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]"	10661506
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HRH1 mRNA"	23146750
C006183	2-(2-aminoethyl)pyridine	2-(2-aminoethyl)pyridine binds to and results in increased activity of HRH1 protein	9657254
C006183	2-(2-aminoethyl)pyridine	HRH1 protein promotes the reaction [2-(2-aminoethyl)pyridine results in increased expression of IL6 mRNA]	9657254
C006183	2-(2-aminoethyl)pyridine	2-(2-aminoethyl)pyridine binds to and results in increased activity of HRH1 protein	16143415
C029345	2-(2-aminoethyl)thiazole	2-(2-aminoethyl)thiazole binds to and results in increased activity of HRH1 protein	12065605
C029345	2-(2-aminoethyl)thiazole	2-(2-aminoethyl)thiazole binds to and results in increased activity of HRH1 protein	2884542
C092716	2-(3-trifluoromethylphenyl)histamine	2-(3-trifluoromethylphenyl)histamine binds to and results in increased activity of HRH1 protein	10869801
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of HRH1 mRNA"	23146750
C026259	2-methylhistamine	2-methylhistamine binds to and results in increased activity of HRH1 protein	12065605
C528564	4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid	4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid binds to and results in decreased activity of HRH1 protein	18298128
C528564	4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid	4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-ylbut-2-enyloxy)acetic acid binds to and results in decreased activity of HRH1 protein	18298128
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of HRH1 mRNA"	18648102
C081972	6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide	6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide binds to and results in increased activity of HRH1 protein	11238657
C081972	6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide	[6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium	11238657
C081972	6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide	HRH1 protein promotes the reaction [6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide results in increased expression of GUSB protein]	11238657
C081972	6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide	HRH1 protein promotes the reaction [6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide results in increased expression of IL6 protein]	11238657
C434584	8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine	"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Pyrilamine binds to HRH1 protein]"	11927170
D000082	Acetaminophen	Acetaminophen results in increased expression of HRH1 mRNA	29067470
D000242	Cyclic AMP	1-Methyl-3-isobutylxanthine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]	2419744
D000242	Cyclic AMP	HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]	2419744
D000242	Cyclic AMP	Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]	2419744
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of HRH1 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of HRH1 gene	27153756
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of HRH1 mRNA	21298039
D000628	Aminophylline	[Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline	16129921
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HRH1 mRNA	16483693
D000929	Antidepressive Agents, Tricyclic	"Antidepressive Agents, Tricyclic results in decreased activity of HRH1 protein"	7296440
D001194	Asbestos	Asbestos results in increased expression of HRH1 mRNA	22398240
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of HRH1 mRNA"	18687144
D016589	Astemizole	Astemizole binds to and results in decreased activity of HRH1 protein	7612054
D016589	Astemizole	Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]	12147327
D016589	Astemizole	[Astemizole binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Aminophylline	16129921
C006656	azatadine	azatadine binds to and results in decreased activity of HRH1 protein	2864258
C006656	azatadine	azatadine binds to and results in decreased activity of HRH1 protein	11291777
C020976	azelastine	azelastine binds to HRH1 protein	2540229
C020976	azelastine	azelastine results in decreased activity of HRH1 protein	21381763
C547126	AZM551248	AZM551248 results in decreased expression of HRH1 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of HRH1 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to HRH1 promoter]	19654925
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HRH1 mRNA"	20382639
D001621	Betahistine	Betahistine binds to and results in increased activity of HRH1 protein	16143415
C006780	bisphenol A	bisphenol A results in increased expression of HRH1 mRNA	29275510
C006780	bisphenol A	bisphenol A results in decreased expression of HRH1 mRNA	25181051
D002104	Cadmium	Cadmium results in decreased expression of HRH1 mRNA	16263506
D002118	Calcium	HRH1 protein affects the reaction [GNA11 protein inhibits the reaction [Pyrilamine results in decreased abundance of Calcium]]	15192105
D002118	Calcium	[6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium	11238657
D002118	Calcium	fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium]	11238657
D002118	Calcium	[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium	11238657
D002118	Calcium	HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]	2419744
D002118	Calcium	HRH1 protein results in increased abundance of Calcium	19443731
D002118	Calcium	Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium]	11527950
D002118	Calcium	Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]]	2419744
D017332	Cetirizine	Cetirizine binds to and results in decreased activity of HRH1 protein	17252940
D017332	Cetirizine	Cetirizine analog binds to HRH1 protein	15482930
D017332	Cetirizine	Cetirizine binds to and results in decreased activity of HRH1 protein	16401869
D017332	Cetirizine	Cetirizine binds to HRH1 protein	15482930
D017332	Cetirizine	Cetirizine binds to and results in decreased activity of HRH1 protein	10071518\|1129177
D002744	Chlorpheniramine	Chlorpheniramine inhibits the reaction [mizolastine binds to HRH1 protein]	7612054
D002744	Chlorpheniramine	Chlorpheniramine binds to and affects the activity of HRH1 protein	17496723
D002744	Chlorpheniramine	Chlorpheniramine binds to and results in decreased activity of HRH1 protein	11432448
D002744	Chlorpheniramine	Chlorpheniramine results in decreased activity of HRH1 protein	8111568
D002744	Chlorpheniramine	Chlorpheniramine binds to and results in decreased activity of HRH1 protein	12128009
D002744	Chlorpheniramine	Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]	12128009\|1456915
D002744	Chlorpheniramine	Chlorpheniramine binds to and results in decreased activity of HRH1 protein	16143415
D002744	Chlorpheniramine	"Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	15054595\|1836008
D002744	Chlorpheniramine	Chlorpheniramine binds to and results in decreased activity of HRH1 protein	10071518\|1113460
D002744	Chlorpheniramine	Chlorpheniramine results in decreased activity of HRH1 protein	8870037
D002927	Cimetidine	Cimetidine binds to and results in decreased activity of HRH1 protein	15159029\|6869119
D002927	Cimetidine	Cimetidine inhibits the reaction [Pyrilamine binds to HRH1 protein]	15159029\|6869119
D002927	Cimetidine	Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]	14569158
D002936	Cinnarizine	Cinnarizine binds to and results in decreased activity of HRH1 protein	2271847
D002974	Clemastine	Clemastine binds to and results in decreased activity of HRH1 protein	2864258
C086108	clobenpropit	[Pyrilamine binds to and results in decreased activity of HRH1 protein] which results in decreased susceptibility to clobenpropit	16488453
D003024	Clozapine	Clozapine binds to HRH1 protein	16983399
D003024	Clozapine	Clozapine binds to HRH1 protein	7520908
C030973	cupric oxide	cupric oxide results in increased expression of HRH1 mRNA	22077320
D016572	Cyclosporine	Cyclosporine results in decreased methylation of HRH1 promoter	27989131
D016572	Cyclosporine	Cyclosporine results in increased expression of HRH1 mRNA	20106945
D003533	Cyproheptadine	Cyproheptadine binds to and results in decreased activity of HRH1 protein	7612054
D003533	Cyproheptadine	Cyproheptadine binds to and results in decreased activity of HRH1 protein	7650688
C121345	desloratadine	desloratadine binds to HRH1 protein	15482930
D003907	Dexamethasone	"Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	15054595\|1551354
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of HRH1 mRNA	27392435
D004041	Dietary Fats	Dietary Fats results in increased expression of HRH1 mRNA	25016146
D004115	Dimethindene	Dimethindene binds to and results in decreased activity of HRH1 protein	7512805
C118996	dimethylhistaprodifen	dimethylhistaprodifen binds to and results in decreased activity of HRH1 protein	12669185
D004155	Diphenhydramine	[Diphenhydramine co-treated with Ranitidine] results in decreased activity of HRH1 protein	16344897
D004155	Diphenhydramine	Diphenhydramine binds to and affects the activity of HRH1 protein	17496723
D004155	Diphenhydramine	Diphenhydramine binds to and results in decreased activity of HRH1 protein	2419744\|2461127\|
D004155	Diphenhydramine	Diphenhydramine binds to and results in increased activity of HRH1 protein	1912125
D004155	Diphenhydramine	Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]	1912125\|2419744
D004155	Diphenhydramine	HRH1 protein promotes the reaction [Diphenhydramine results in decreased susceptibility to CXCL8 protein]	7522859
D004155	Diphenhydramine	[Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin	12856827
D004155	Diphenhydramine	Diphenhydramine binds to and results in decreased activity of HRH1 protein	10071518\|1113460
C009871	diphenylpyraline	diphenylpyraline binds to and results in increased activity of HRH1 protein	1912125
C009871	diphenylpyraline	diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein]	1912125
D004298	Dopamine	"[1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog binds to and results in increased activity of HRH1 protein] promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]"	10661506
C058249	ebastine	ebastine binds to and results in decreased activity of HRH1 protein	11134603
C121361	efletirizine	efletirizine analog binds to HRH1 protein	15482930
C043345	emedastine	emedastine binds to and results in decreased activity of HRH1 protein	2883850
D004726	Endosulfan	Endosulfan results in increased expression of HRH1 mRNA	16263506
C053090	epinastine	[epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine	12832840
C053090	epinastine	"epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	19075512
C053090	epinastine	epinastine binds to and results in decreased activity of HRH1 protein	7650688
D004917	Erythromycin	[Diphenhydramine results in decreased activity of HRH1 protein] which results in decreased susceptibility to Erythromycin	12856827
C507035	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Lipopolysaccharides results in increased expression of HRH1 mRNA]	21255012
C093230	fexofenadine	fexofenadine binds to and results in decreased activity of HRH1 protein	11238657
C093230	fexofenadine	fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium]	11238657
C093230	fexofenadine	fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein]	11238657
C093230	fexofenadine	fexofenadine binds to and results in decreased activity of HRH1 protein	19652466
C093230	fexofenadine	fexofenadine binds to and results in decreased activity of HRH1 protein	17133778\|2502013
D005473	Fluoxetine	HRH1 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine]	20021991
C037032	galangin	galangin results in decreased expression of HRH1 mRNA	23535185
D006160	Guanosine Triphosphate	Guanosine Triphosphate affects the reaction [Histamine binds to and results in increased activity of HRH1 protein]	12669185
D006160	Guanosine Triphosphate	Guanosine Triphosphate affects the reaction [histaprodifen binds to and results in increased activity of HRH1 protein]	12669185
D006160	Guanosine Triphosphate	Guanosine Triphosphate affects the reaction [methylhistaprodifen binds to and results in increased activity of HRH1 protein]	12669185
D006160	Guanosine Triphosphate	Guanosine Triphosphate analog inhibits the reaction [Histamine binds to HRH1 protein]	3728201
D006160	Guanosine Triphosphate	Guanosine Triphosphate inhibits the reaction [Histamine binds to HRH1 protein]	3728201
D006160	Guanosine Triphosphate	Magnesium inhibits the reaction [Guanosine Triphosphate inhibits the reaction [Histamine binds to HRH1 protein]]	3728201
D006160	Guanosine Triphosphate	Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]]	2419744
D006569	Hesperidin	Hesperidin affects the activity of HRH1 protein	19016407
D006569	Hesperidin	[Hesperidin affects the activity of HRH1 protein] which results in increased abundance of Nitric Oxide	19016407
D006632	Histamine	Guanosine Triphosphate affects the reaction [Histamine binds to and results in increased activity of HRH1 protein]	12669185
D006632	Histamine	Guanosine Triphosphate analog inhibits the reaction [Histamine binds to HRH1 protein]	3728201
D006632	Histamine	Guanosine Triphosphate inhibits the reaction [Histamine binds to HRH1 protein]	3728201
D006632	Histamine	Histamine binds to and results in increased activity of HRH1 protein	12669185
D006632	Histamine	Histamine binds to HRH1 protein	3728201
D006632	Histamine	Magnesium inhibits the reaction [Guanosine Triphosphate inhibits the reaction [Histamine binds to HRH1 protein]]	3728201
D006632	Histamine	Triprolidine inhibits the reaction [Histamine results in increased activity of HRH1 protein]	12669185
D006632	Histamine	1-Methyl-3-isobutylxanthine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]	2419744
D006632	Histamine	Astemizole inhibits the reaction [Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]]	12147327
D006632	Histamine	fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased abundance of Calcium]	11238657
D006632	Histamine	fexofenadine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of GUSB protein]	11238657
D006632	Histamine	Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]]	2419744
D006632	Histamine	Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]	2419744
D006632	Histamine	Histamine results in decreased activity of [KCNQ2 protein co-treated with KCNQ3 protein co-treated with HRH1 protein]	12147327
D006632	Histamine	Histamine results in increased activity of HRH1 protein	11238657
D006632	Histamine	[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium	11238657
D006632	Histamine	Histamine results in increased expression of HRH1 mRNA	23333628
D006632	Histamine	HRH1 affects the reaction [Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]]	20040740
D006632	Histamine	HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]	2419744
D006632	Histamine	HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]	2419744
D006632	Histamine	HRH1 protein promotes the reaction [Histamine results in increased expression of GUSB protein]	11238657
D006632	Histamine	HRH1 protein promotes the reaction [Histamine results in increased expression of IL6 protein]	11238657
D006632	Histamine	HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]	2419744
D006632	Histamine	Quercetin inhibits the reaction [Histamine results in increased expression of HRH1 mRNA]	23333628
D006632	Histamine	Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]	11306145
D006632	Histamine	[Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein	11306145
D006632	Histamine	[Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein	11306145
D006632	Histamine	Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium]	11527950
D006632	Histamine	Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]	2419744
D006632	Histamine	Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]]	2419744
D006632	Histamine	Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]]	2419744
D006632	Histamine	HRH1 protein affects the susceptibility to Histamine	12095164
D006632	Histamine	[epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine	12832840
D006632	Histamine	Histamine binds to and results in increased activity of HRH1 protein	15167971\|1614341
D006632	Histamine	[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine Hydrobromide	19215234
D006632	Histamine	[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein	15167971
D006632	Histamine	Histamine results in increased activity of HRH1 protein	16354729
D006632	Histamine	[Histamine results in increased activity of HRH1 protein] which affects the transport of Potassium	16354729
D006632	Histamine	Histamine results in increased expression of HRH1 mRNA	18360087
D006632	Histamine	Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine Hydrobromide]	19215234
D006632	Histamine	Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]	15167971
D006632	Histamine	Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA]	18360087
D006632	Histamine	[Tripelennamine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine	12832840
D006632	Histamine	Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]	15167971
C087869	histamine trifluoromethyl-toluidide	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein]"	18508907
C087869	histamine trifluoromethyl-toluidide	histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein	18508907
C087869	histamine trifluoromethyl-toluidide	Terfenadine inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein]	18508907
C087869	histamine trifluoromethyl-toluidide	W 7 inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein]	18508907
C087869	histamine trifluoromethyl-toluidide	histamine trifluoromethyl-toluidide analog results in increased activity of HRH1 protein	16354729
C087869	histamine trifluoromethyl-toluidide	[histamine trifluoromethyl-toluidide analog results in increased activity of HRH1 protein] which affects the transport of Potassium	16354729
C118994	histaprodifen	Guanosine Triphosphate affects the reaction [histaprodifen binds to and results in increased activity of HRH1 protein]	12669185
C118994	histaprodifen	histaprodifen binds to and results in increased activity of HRH1 protein	12669185
C118994	histaprodifen	Triprolidine inhibits the reaction [histaprodifen results in increased activity of HRH1 protein]	12669185
C118994	histaprodifen	histaprodifen binds to and results in increased activity of HRH1 protein	15167971
C118994	histaprodifen	[histaprodifen binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein	15167971
D006919	Hydroxyzine	Hydroxyzine binds to and results in decreased activity of HRH1 protein	19057127\|2864258
D015056	1-Methyl-3-isobutylxanthine	1-Methyl-3-isobutylxanthine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]	2419744
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of HRH1 mRNA	27392435
D007665	Ketotifen	Ketotifen binds to and results in decreased activity of HRH1 protein	10029352\|1243104
D007665	Ketotifen	Ketotifen results in decreased activity of HRH1 protein	16386349
C047781	lamotrigine	HRH1 protein results in increased susceptibility to lamotrigine	20021991
C029310	lard	lard results in increased expression of HRH1 mRNA	26115784
D007854	Lead	Lead affects the expression of HRH1 mRNA	28903495
C047340	levocabastine	levocabastine binds to and results in decreased activity of HRH1 protein	8612114
D008070	Lipopolysaccharides	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Lipopolysaccharides results in increased expression of HRH1 mRNA]	21255012
D008070	Lipopolysaccharides	HRH1 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]	21255012
D008070	Lipopolysaccharides	Lipopolysaccharides promotes the reaction [Pyrilamine binds to HRH1 protein]	21255012
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of HRH1 mRNA	21255012
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of HRH1 protein	21255012
D008070	Lipopolysaccharides	TLR4 protein promotes the reaction [Lipopolysaccharides results in increased expression of HRH1 mRNA]	21255012
D017336	Loratadine	Loratadine binds to and results in decreased activity of HRH1 protein	7612054
D017336	Loratadine	Loratadine inhibits the reaction [mizolastine binds to HRH1 protein]	7612054
D017336	Loratadine	Loratadine analog binds to HRH1 protein	15482930
D017336	Loratadine	Loratadine binds to HRH1 protein	15482930
D017336	Loratadine	Loratadine binds to and results in decreased activity of HRH1 protein	10071518\|1113460
D008274	Magnesium	Magnesium inhibits the reaction [Guanosine Triphosphate inhibits the reaction [Histamine binds to HRH1 protein]]	3728201
C025340	manganese chloride	manganese chloride results in decreased methylation of HRH1 gene	27913844
C088248	mepifiline	mepifiline binds to and results in decreased activity of HRH1 protein	12100006
C006069	mequitazine	mequitazine binds to and results in decreased activity of HRH1 protein	7612054
C006069	mequitazine	mequitazine binds to and results in decreased activity of HRH1 protein	12244568\|7650688
D008727	Methotrexate	Methotrexate results in increased expression of HRH1 mRNA	17400583
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of HRH1 protein"	28790194
C118995	methylhistaprodifen	Guanosine Triphosphate affects the reaction [methylhistaprodifen binds to and results in increased activity of HRH1 protein]	12669185
C118995	methylhistaprodifen	methylhistaprodifen binds to and results in increased activity of HRH1 protein	12669185
C118995	methylhistaprodifen	Triprolidine inhibits the reaction [methylhistaprodifen results in increased activity of HRH1 protein]	12669185
C118995	methylhistaprodifen	methylhistaprodifen results in increased activity of HRH1 protein	21276809
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of HRH1 mRNA"	20188158
D008803	Mianserin	Mianserin binds to and results in decreased activity of HRH1 protein	7650688
C048107	milnacipran	milnacipran results in increased expression of HRH1 mRNA	21157932
C076170	mizolastine	Chlorpheniramine inhibits the reaction [mizolastine binds to HRH1 protein]	7612054
C076170	mizolastine	Loratadine inhibits the reaction [mizolastine binds to HRH1 protein]	7612054
C076170	mizolastine	mizolastine binds to and results in decreased activity of HRH1 protein	7612054
C076170	mizolastine	mizolastine inhibits the reaction [Pyrilamine binds to HRH1 protein]	7612054
C076170	mizolastine	Pyrilamine inhibits the reaction [mizolastine binds to HRH1 protein]	7612054
C076170	mizolastine	Terfenadine inhibits the reaction [mizolastine binds to HRH1 protein]	7612054
C076170	mizolastine	mizolastine binds to and results in decreased activity of HRH1 protein	11291777
D009020	Morphine	Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]	12128009\|1456915
D009020	Morphine	Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]	14569158
D009020	Morphine	HRH1 results in decreased susceptibility to Morphine	12128009\|1456915
D009532	Nickel	Nickel results in increased expression of HRH1 mRNA	24768652\|2558310
D009532	Nickel	HRH1 affects the susceptibility to Nickel	19839048
D009569	Nitric Oxide	[Hesperidin affects the activity of HRH1 protein] which results in increased abundance of Nitric Oxide	19016407
C076029	olanzapine	HRH1 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine]	20021991
C076029	olanzapine	olanzapine binds to HRH1 protein	16983399
C076029	olanzapine	olanzapine binds to HRH1 protein	24389121
D000069605	Olopatadine Hydrochloride	Olopatadine Hydrochloride binds to HRH1 protein	9433371
D000069605	Olopatadine Hydrochloride	"Olopatadine Hydrochloride inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	18360087\|1907551
D000069605	Olopatadine Hydrochloride	Olopatadine Hydrochloride binds to and results in decreased activity of HRH1 protein	16337938\|8951675
D017374	Paroxetine	Paroxetine results in increased expression of HRH1 mRNA	21157932
D052638	Particulate Matter	Particulate Matter analog results in increased expression of HRH1 mRNA	10051702
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of HRH1 mRNA	18593933
C000593032	PGW5 compound	PGW5 compound binds to HRH1 protein	24389121
C005430	phenindamine	phenindamine binds to and results in decreased activity of HRH1 protein	7650688
D010716	Phosphatidylinositols	HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]	2419744
D010716	Phosphatidylinositols	Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]]	2419744
D010936	Plant Extracts	Plant Extracts results in decreased expression of HRH1 mRNA	23557933
D010938	Plant Oils	Plant Oils results in increased expression of HRH1 mRNA	23370395
D011188	Potassium	[Histamine results in increased activity of HRH1 protein] which affects the transport of Potassium	16354729
D011188	Potassium	[histamine trifluoromethyl-toluidide analog results in increased activity of HRH1 protein] which affects the transport of Potassium	16354729
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of HRH1 mRNA	22714537
D011398	Promethazine	Promethazine binds to and results in decreased activity of HRH1 protein	15159029\|6869119
D011398	Promethazine	Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein]	15159029\|6869119
D011398	Promethazine	Promethazine binds to and results in decreased activity of HRH1 protein	1377455
D011398	Promethazine	Promethazine binds to and results in increased activity of HRH1 protein	1912125
D011398	Promethazine	Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein]	1912125
D011398	Promethazine	Promethazine binds to and results in decreased activity of HRH1 protein	12244568\|1526567
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of HRH1 mRNA	24780913
C479122	putranjivain A	putranjivain A results in decreased expression of HRH1 mRNA	24361550
D011738	Pyrilamine	Cimetidine inhibits the reaction [Pyrilamine binds to HRH1 protein]	15159029\|6869119
D011738	Pyrilamine	Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein]	15159029\|6869119
D011738	Pyrilamine	Pyrilamine binds to HRH1 protein	15159029\|3728201
D011738	Pyrilamine	Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein]	15159029\|6869119
D011738	Pyrilamine	HRH1 protein affects the reaction [GNA11 protein inhibits the reaction [Pyrilamine results in decreased abundance of Calcium]]	15192105
D011738	Pyrilamine	mizolastine inhibits the reaction [Pyrilamine binds to HRH1 protein]	7612054
D011738	Pyrilamine	Pyrilamine binds to and results in decreased activity of [GNA11 protein binds to HRH1 protein]	15192105
D011738	Pyrilamine	Pyrilamine binds to and results in decreased activity of HRH1 protein	7612054
D011738	Pyrilamine	Pyrilamine inhibits the reaction [mizolastine binds to HRH1 protein]	7612054
D011738	Pyrilamine	Pyrilamine results in decreased activity of HRH1 protein	15192105
D011738	Pyrilamine	Pyrilamine binds to and affects the activity of HRH1 protein	17496723
D011738	Pyrilamine	Pyrilamine binds to HRH1 protein	17496723
D011738	Pyrilamine	Diphenhydramine inhibits the reaction [Pyrilamine binds to HRH1 protein]	1912125\|2419744
D011738	Pyrilamine	diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein]	1912125
D011738	Pyrilamine	Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]]	2419744
D011738	Pyrilamine	Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]	2419744
D011738	Pyrilamine	HRH1 protein promotes the reaction [Pyrilamine results in decreased susceptibility to CXCL8 protein]	7522859
D011738	Pyrilamine	Lipopolysaccharides promotes the reaction [Pyrilamine binds to HRH1 protein]	21255012
D011738	Pyrilamine	Promethazine inhibits the reaction [Pyrilamine binds to HRH1 protein]	1912125
D011738	Pyrilamine	Pyrilamine binds to HRH1 protein	1912125\|21255012
D011738	Pyrilamine	Pyrilamine results in decreased activity of HRH1 protein	8111568
D011738	Pyrilamine	Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein]	1912125\|2419744
D011738	Pyrilamine	"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Pyrilamine binds to HRH1 protein]"	11927170
D011738	Pyrilamine	Pyrilamine binds to and results in decreased activity of HRH1 protein	11640976\|1921523
D011738	Pyrilamine	[Pyrilamine binds to and results in decreased activity of HRH1 protein] which results in decreased susceptibility to clobenpropit	16488453
D011738	Pyrilamine	Pyrilamine binds to HRH1 protein	11927170\|1551354
D011738	Pyrilamine	Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine Hydrobromide]	19215234
D011738	Pyrilamine	Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]	15167971
D011738	Pyrilamine	Pyrilamine results in decreased activity of HRH1 protein	21276809
D011738	Pyrilamine	Tacrine inhibits the reaction [Pyrilamine binds to HRH1 protein]	2606156
D011738	Pyrilamine	"Toluene 2,4-Diisocyanate promotes the reaction [Pyrilamine binds to HRH1 protein]"	15513549
D011738	Pyrilamine	Pyrilamine binds to and results in decreased activity of HRH1 protein	11134603\|1623613
D011738	Pyrilamine	Pyrilamine results in decreased activity of HRH1 protein	8866624
D011744	Pyrimidinones	Pyrimidinones analog binds to and results in decreased activity of HRH1 protein	17252940
D011794	Quercetin	Quercetin inhibits the reaction [Histamine results in increased expression of HRH1 mRNA]	23333628
D011794	Quercetin	Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HRH1 mRNA]	23333628
D011794	Quercetin	"Quercetin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	23333628
D011899	Ranitidine	[Diphenhydramine co-treated with Ranitidine] results in decreased activity of HRH1 protein	16344897
C450800	ReN 1869	ReN 1869 binds to and results in decreased activity of HRH1 protein	15112866
D012293	Rifampin	Rifampin results in increased expression of HRH1 mRNA	24552687
C064758	Ro 31-8220	Ro 31-8220 inhibits the reaction [Histamine results in increased expression of HRH1 mRNA]	18360087
D012601	Scopolamine Hydrobromide	[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine Hydrobromide	19215234
D012601	Scopolamine Hydrobromide	Pyrilamine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in decreased susceptibility to Scopolamine Hydrobromide]	19215234
C090832	sho-seiryu-to	"sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	19050374
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of HRH1 mRNA	25351596
C017947	sodium arsenite	sodium arsenite affects the methylation of HRH1 gene	28589171
D013619	Tacrine	Tacrine inhibits the reaction [Pyrilamine binds to HRH1 protein]	2606156
D016593	Terfenadine	Terfenadine binds to and results in decreased activity of HRH1 protein	7612054
D016593	Terfenadine	Terfenadine inhibits the reaction [mizolastine binds to HRH1 protein]	7612054
D016593	Terfenadine	Terfenadine inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein]	18508907
D016593	Terfenadine	Terfenadine binds to and results in decreased activity of HRH1 protein	11291777\|1224456
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HRH1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HRH1 mRNA	15977195
D013755	Tetradecanoylphorbol Acetate	Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HRH1 mRNA]	23333628
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of HRH1 mRNA	23333628
C005795	thenalidine	thenalidine binds to and results in decreased activity of HRH1 protein	6141553
D014051	Toluene 2,4-Diisocyanate	"Chlorpheniramine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	15054595\|1836008
D014051	Toluene 2,4-Diisocyanate	"Dexamethasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	15054595\|1551354
D014051	Toluene 2,4-Diisocyanate	"epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	19075512
D014051	Toluene 2,4-Diisocyanate	"Olopatadine Hydrochloride inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	18360087\|1907551
D014051	Toluene 2,4-Diisocyanate	"Quercetin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	23333628
D014051	Toluene 2,4-Diisocyanate	"sho-seiryu-to inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA]"	19050374
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate promotes the reaction [Pyrilamine binds to HRH1 protein]"	15513549
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA"	15054595\|1551354
D014051	Toluene 2,4-Diisocyanate	"Toluene 2,4-Diisocyanate results in increased expression of HRH1 protein"	18360087
D014309	Tripelennamine	[Tripelennamine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine	12832840
D014309	Tripelennamine	Tripelennamine binds to and results in decreased activity of HRH1 protein	10210152\|2881522
D014311	Triprolidine	Triprolidine binds to and results in decreased activity of HRH1 protein	12669185\|1515902
D014311	Triprolidine	Triprolidine inhibits the reaction [Histamine results in increased activity of HRH1 protein]	12669185
D014311	Triprolidine	Triprolidine inhibits the reaction [histaprodifen results in increased activity of HRH1 protein]	12669185
D014311	Triprolidine	Triprolidine inhibits the reaction [methylhistaprodifen results in increased activity of HRH1 protein]	12669185
D014311	Triprolidine	Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein]	15159029\|6869119
D014311	Triprolidine	HRH1 protein promotes the reaction [Triprolidine results in decreased susceptibility to CXCL8 protein]	7522859
D014311	Triprolidine	Triprolidine binds to and results in decreased activity of HRH1 protein	11306145\|1152795
D014311	Triprolidine	Triprolidine binds to and results in increased activity of HRH1 protein	1912125
D014311	Triprolidine	Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]	11306145
D014311	Triprolidine	[Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein	11306145
D014311	Triprolidine	[Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein	11306145
D014311	Triprolidine	Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium]	11527950
D014311	Triprolidine	Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]	2419744
D014311	Triprolidine	Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]]	2419744
D014311	Triprolidine	Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]]	2419744
D014311	Triprolidine	Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein]	1912125\|2419744
D014311	Triprolidine	Triprolidine binds to and results in decreased activity of HRH1 protein	12714356
D014311	Triprolidine	Triprolidine binds to and results in decreased activity of HRH1 protein	10661506\|1614341
D014311	Triprolidine	Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]	15167971
D014311	Triprolidine	Triprolidine results in decreased activity of HRH1 protein	21276809
D014311	Triprolidine	Triprolidine binds to and results in decreased activity of HRH1 protein	16354729\|7650688
D014635	Valproic Acid	Valproic Acid affects the expression of HRH1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of HRH1 gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions analog results in increased expression of HRH1 mRNA	10051702
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of HRH1 gene	25560391
C017967	W 7	W 7 inhibits the reaction [histamine trifluoromethyl-toluidide results in increased activity of HRH1 protein]	18508907
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of HRH1 mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004930	G-protein coupled receptor activity	-	IBA	21873635
GO:0004930	G-protein coupled receptor activity	-	TAS	7925364
GO:0004969	histamine receptor activity	-	ISS	-
GO:0004993	G-protein coupled serotonin receptor activity	-	IBA	21873635
GO:0030594	neurotransmitter receptor activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006954	inflammatory response	-	TAS	10818238
GO:0007186	G-protein coupled receptor signaling pathway	-	ISS	-
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	IBA	21873635
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	-	TAS	8280179
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007613	memory	-	IEA	-
GO:0008542	visual learning	-	IEA	-
GO:0019229	regulation of vasoconstriction	-	IBA	21873635
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process	-	ISS	-
GO:0043114	regulation of vascular permeability	-	IEA	-
GO:0045907	positive regulation of vasoconstriction	-	IEA	-
GO:0048016	inositol phosphate-mediated signaling	-	ISS	-
GO:0048167	regulation of synaptic plasticity	-	IEA	-
GO:0048245	eosinophil chemotaxis	-	IEA	-
GO:0050804	modulation of chemical synaptic transmission	-	IBA	21873635
GO:0071420	cellular response to histamine	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	IDA	-
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	ISS	-
GO:0030425	dendrite	-	IBA	21873635

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390650	Histamine receptors	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22722500	Association study of 27 annotated genes for clozapine pharmacogenetics: validation of preexisting studies and identification of a new candidate gene, ABCB1, for treatment response. (2012 Aug)	Lee ST	J Clin Psychopharmacol