Gene: SLC35F4

341880
C14orf36|c14_5373
solute carrier family 35 member F4
protein-coding
14q22.3-q23.1
Ensembl:ENSG00000151812 Vega:OTTHUMG00000171317 UniprotKB:A4IF30
NC_000014.9
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.922e-1 (AD)  8.096e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12435601chr14:57979379 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11623923chr14:57576035 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01702210chr14:58064926SLC35F4Promoter5.357e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLX60.839
PENK0.792
TAC10.745
GLRA20.744
CALB10.742
COCH0.733
KLHL130.723
GAD20.723
DLX50.72
ZCCHC120.713

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAGEA12-0.447
RGL3-0.419
PPP1R13L-0.409
ZIC2-0.4
OTOS-0.397
FYCO1-0.397
TBX15-0.385
ITPRIP-0.385
ABCC9-0.382
ZIC5-0.379

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of SLC35F4 mRNA17562736
D001280AtrazineAtrazine results in decreased expression of SLC35F4 mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of SLC35F4 mRNA25181051
D003471CuprizoneCuprizone results in increased expression of SLC35F4 mRNA27523638
D010936Plant ExtractsPlant Extracts results in decreased expression of SLC35F4 mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SLC35F4 mRNA23608068
D011441PropylthiouracilPropylthiouracil affects the expression of SLC35F4 mRNA24780913
C017947sodium arsenitesodium arsenite affects the methylation of SLC35F4 gene28589171
D012999SomanSoman results in decreased expression of SLC35F4 mRNA19281266
D014635Valproic AcidValproic Acid results in decreased methylation of SLC35F4 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SLC35F4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0022857transmembrane transporter activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0055085transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal