Gene: ITGA9

3680
ALPHA-RLC|ITGA4L|RLC
integrin subunit alpha 9
protein-coding
3p22.2
Ensembl:ENSG00000144668 MIM:603963 Vega:OTTHUMG00000130815 UniprotKB:Q13797
NG_016166.1
SNP Mapped
3   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.038e-1 (AD)  3.408e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11717973chr3:37720523 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs6550481chr3:37573219 (GRCh38.p7)T>A / T>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs919113chr3:37558979 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF30.87
KLHL180.862
TIAM20.858
PREP0.856
MAPK140.854
CDYL20.85
LUZP10.849
IARS0.848
RAPGEF20.848
PIP4K2C0.848

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.453
BCAS1-0.428
CTNNA3-0.418
S100A1-0.413
HEY2-0.411
C5orf64-0.411
MYOM1-0.404
SOX3-0.398
LPAR1-0.395
ACAP1-0.39

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of ITGA9 mRNA"27291303
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ITGA9 mRNA17562736
C006632arsenic trioxidearsenic trioxide results in decreased expression of ITGA9 mRNA26705709
C547126AZM551248AZM551248 results in increased expression of ITGA9 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ITGA9 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ITGA9 mRNA22228805
C006780bisphenol Abisphenol A results in increased methylation of ITGA9 promoter27312807
D002945CisplatinCisplatin results in increased expression of ITGA9 mRNA12066199
D002945CisplatinCisplatin results in decreased expression of ITGA9 mRNA22023808
C118739entinostatentinostat results in increased expression of ITGA9 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
D017313FenretinideFenretinide results in increased expression of ITGA9 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ITGA9 mRNA25613284
D008727MethotrexateMethotrexate results in decreased expression of ITGA9 mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ITGA9 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ITGA9 mRNA"25620056
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ITGA9 mRNA25729387
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ITGA9 mRNA26272509
D010656PhenylephrinePhenylephrine results in increased expression of ITGA9 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ITGA9 mRNA26272509
C005556propionaldehydepropionaldehyde results in decreased expression of ITGA9 mRNA26079696
C502851quinocetonequinocetone results in increased expression of ITGA9 mRNA27046791
D012715Sesame OilSesame Oil results in increased expression of ITGA9 mRNA29191790
C017947sodium arsenitesodium arsenite affects the methylation of ITGA9 gene28589171
D013629TamoxifenTamoxifen results in decreased expression of ITGA9 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ITGA9 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ITGA9 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of ITGA9 mRNA23409001
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ITGA9 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ITGA9 mRNA21934132
D014212TretinoinTretinoin results in increased expression of ITGA9 mRNA24977338
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ITGA9 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of ITGA9 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ITGA9 mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of ITGA9 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of ITGA9 mRNA24896083
D014638VanadatesVanadates results in decreased expression of ITGA9 mRNA22714537
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ITGA9 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of ITGA9 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005518collagen binding-IEA-  
GO:0043236laminin binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IGI21060781  
GO:0007229integrin-mediated signaling pathway-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0030593neutrophil chemotaxis-IEA-  
GO:0042060wound healing-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0008305integrin complex-TAS8245132  
GO:0009925basal plasma membrane-IEA-  
GO:0034679integrin alpha9-beta1 complex-IEA-  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa04514Cell adhesion molecules (CAMs)
hsa04810Regulation of actin cytoskeleton
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-216083Integrin cell surface interactionsIEA
R-HSA-3000178ECM proteoglycansTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-445144Signal transduction by L1TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal