Gene info: ID 391

Gene: RHOG

GENE ID: 391

Synonyms: ARHG

Description: ras homolog family member G

Gene type: protein-coding

Location: 11p15.4

dbXrefs: Ensembl:ENSG00000177105 MIM:179505 Vega:OTTHUMG00000012287 UniprotKB:P84095

RefSeq: NC_000011.10

Retrived from: PubMed|SNP Mapped

SNPs: 2 ANCO-SNPs

Phenotype: ND|AD

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.566e-1 (AD) 6.527e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs1451724	chr11:3835438 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs1451722	chr11:3835323 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg24497361	chr11:3858493	RHOG		6.400e-12	Smoking	27651444
cg24497361	chr11:3858493	RHOG		5.070e-8	Alcohol consumption per day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CDC42EP1	0.919
SYNGR2	0.91
SLC35D2	0.908
LITAF	0.902
CD9	0.89
ELOVL1	0.886
GLTP	0.881
RRBP1	0.877
TFEB	0.876
VWA1	0.87

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CNGB1	-0.513
CUX2	-0.498
FREM3	-0.484
FAM163A	-0.477
SSTR4	-0.475
HS6ST3	-0.473
FBLN7	-0.47
NDST3	-0.467
CNTN5	-0.466
GPR26	-0.464

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RHOG mRNA"	21394737
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of RHOG mRNA"	21346803
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of RHOG gene	27153756
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of RHOG mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of RHOG gene	25304211
D001241	Aspirin	Aspirin results in decreased expression of RHOG mRNA	15928584
C006780	bisphenol A	bisphenol A results in increased expression of RHOG mRNA	25181051
C117342	calfactant	"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of RHOG protein"	23026733
D002734	Chlorophyll	"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of RHOG mRNA]"	22079312
D003042	Cocaine	Cocaine affects the expression of RHOG mRNA	20187946
D003471	Cuprizone	Cuprizone results in decreased expression of RHOG mRNA	27523638
D016572	Cyclosporine	Cyclosporine results in increased expression of RHOG mRNA	25562108
C041517	dibenzo(a,l)pyrene	"Chlorophyll inhibits the reaction [dibenzo(a,l)pyrene results in increased expression of RHOG mRNA]"	22079312
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in increased expression of RHOG mRNA"	22079312
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of RHOG mRNA	26924002
D004785	Environmental Pollutants	Environmental Pollutants affects the expression of RHOG mRNA	19118595
C540355	fenamidone	fenamidone results in increased expression of RHOG mRNA	27029645
D005480	Flurbiprofen	Flurbiprofen results in increased expression of RHOG mRNA	16949054
D009240	N-Formylmethionine Leucyl-Phenylalanine	RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]	16621998
D009240	N-Formylmethionine Leucyl-Phenylalanine	RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]	16621998
D009240	N-Formylmethionine Leucyl-Phenylalanine	RHOG protein affects the susceptibility to N-Formylmethionine Leucyl-Phenylalanine	16621998
D005839	Gentamicins	Gentamicins results in increased expression of RHOG mRNA	22061828
D015759	Ionomycin	pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RHOG mRNA]	15477007
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RHOG mRNA	15477007
D007657	Ketone Bodies	Ketone Bodies results in decreased expression of RHOG mRNA	16807920
D015735	Mifepristone	Mifepristone results in decreased expression of RHOG mRNA	17584828
D037742	Nanotubes, Carbon	"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of RHOG protein"	23026733
D009532	Nickel	Nickel results in increased expression of RHOG mRNA	24768652\|2558310
C018620	oleoresins	oleoresins results in decreased expression of RHOG mRNA	20008804
D010100	Oxygen	Oxygen deficiency results in increased expression of RHOG mRNA	24205000
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of RHOG protein	26178269
C006253	pirinixic acid	pirinixic acid results in decreased expression of RHOG mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of RHOG mRNA	18301758
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of RHOG mRNA	24780913
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of RHOG mRNA	27029645
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RHOG mRNA]	15477007
D012643	Selenium	Selenium results in increased expression of RHOG mRNA	19244175
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of RHOG protein	28918527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of RHOG mRNA	21570461\|2468072
D013755	Tetradecanoylphorbol Acetate	pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RHOG mRNA]	15477007
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RHOG mRNA	15477007
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of RHOG gene	27618143
C025643	vinclozolin	vinclozolin results in increased expression of RHOG mRNA	23034163
D014810	Vitamin E	Vitamin E results in increased expression of RHOG mRNA	19244175
C088658	zoledronic acid	zoledronic acid results in increased expression of RHOG protein	28871336

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003924	GTPase activity	-	IBA	21873635
GO:0003924	GTPase activity	-	IDA	12376551
GO:0005515	protein binding	-	IPI	12879077 20679435
GO:0005525	GTP binding	-	IBA	21873635
GO:0005525	GTP binding	-	IEA	-
GO:0019901	protein kinase binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007015	actin filament organization	-	IBA	21873635
GO:0007163	establishment or maintenance of cell polarity	-	IBA	21873635
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007266	Rho protein signal transduction	-	IBA	21873635
GO:0007266	Rho protein signal transduction	-	IDA	12376551
GO:0008284	positive regulation of cell proliferation	-	TAS	1620121
GO:0008360	regulation of cell shape	-	IBA	21873635
GO:0016601	Rac protein signal transduction	-	IDA	12376551
GO:0030036	actin cytoskeleton organization	-	IBA	21873635
GO:0030036	actin cytoskeleton organization	-	IDA	12545154
GO:0030865	cortical cytoskeleton organization	-	IBA	21873635
GO:0032956	regulation of actin cytoskeleton organization	-	IBA	21873635
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043652	engulfment of apoptotic cell	-	IBA	21873635
GO:0045893	positive regulation of transcription, DNA-templated	-	IDA	12545154
GO:0051056	regulation of small GTPase mediated signal transduction	-	TAS	-
GO:0060326	cell chemotaxis	-	IMP	20679435
GO:0090630	activation of GTPase activity	-	IMP	20679435
GO:1900027	regulation of ruffle assembly	-	IEA	-
GO:1903078	positive regulation of protein localization to plasma membrane	-	IMP	20679435

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	IBA	21873635
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	TAS	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0005938	cell cortex	-	IBA	21873635
GO:0030667	secretory granule membrane	-	TAS	-
GO:0031410	cytoplasmic vesicle	-	IBA	21873635
GO:0031982	vesicle	-	IBA	21873635
GO:0042995	cell projection	-	IBA	21873635
GO:0043231	intracellular membrane-bounded organelle	-	IBA	21873635
GO:0070062	extracellular exosome	-	HDA	19056867 20458337 23533145

KEGG ID	KEGG Term
hsa05100	Bacterial invasion of epithelial cells
hsa05131	Shigellosis

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114604	GPVI-mediated activation cascade	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-194315	Signaling by Rho GTPases	TAS
R-HSA-194840	Rho GTPase cycle	TAS
R-HSA-195258	RHO GTPase Effectors	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416482	G alpha (12/13) signalling events	TAS
R-HSA-5625970	RHO GTPases activate KTN1	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22701635	Serum resistin and kidney function: a family-based study in non-diabetic, untreated individuals. (2012)	Menzaghi C	PLoS One
21752884	Circulating testosterone and SHBG concentrations are heritable in women: the Framingham Heart Study. (2011 Sep)	Coviello AD	J Clin Endocrinol Metab
24692236	Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. (2014 Jun)	Kos MZ	Am J Med Genet B Neuropsychiatr Genet
27318301	Genome-wide significant loci for addiction and anxiety. (2016 Aug)	Hodgson K	Eur Psychiatry
23746309	The heritability of circulating testosterone, oestradiol, oestrone and sex hormone binding globulin concentrations in men: the Framingham Heart Study. (2014 Feb)	Travison TG	Clin Endocrinol (Oxf)