Gene: NCAM2

4685
NCAM21
neural cell adhesion molecule 2
protein-coding
21q21.1
Ensembl:ENSG00000154654 MIM:602040 Vega:OTTHUMG00000078121 UniprotKB:O15394
NC_000021.9
SNP Mapped
7   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.268e-2 (AD)  9.283e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8126935chr21:21315260 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7279496chr21:21307316 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs2218433chr21:21305454 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs8127865chr21:21271400 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4605456chr21:21264514 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2826660chr21:21116096 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2826659chr21:21115536 (GRCh38.p7)A>C / A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBR30.933
CLASP20.932
FAM98B0.931
TRIM230.931
ANKRD460.929
VTA10.928
ERLEC10.928
VKORC1L10.926
NDFIP20.925
LMBRD20.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.53
CSAG1-0.491
OR4F29-0.488
MTRNR2L10-0.444
MTRNR2L6-0.434
MTRNR2L9-0.419
CST7-0.405
MTRNR2L2-0.403
KCNJ15-0.402
CXCR2-0.399

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of NCAM2 mRNA"25270620
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of NCAM2 mRNA"28903501
C5495433-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid analog results in increased expression of NCAM2 mRNA25716159
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCAM2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCAM2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NCAM2 mRNA17585979
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NCAM2 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NCAM2 gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of NCAM2 mRNA26705709
C015001arsenitearsenite results in increased methylation of NCAM2 promoter23974009
D001280AtrazineAtrazine results in decreased expression of NCAM2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of NCAM2 mRNA21714911
D004958EstradiolEstradiol results in decreased expression of NCAM2 mRNA21185374
C006780bisphenol Abisphenol A affects the expression of NCAM2 mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NCAM2 promoter23359474
C006780bisphenol Abisphenol A results in decreased expression of NCAM2 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of NCAM2 mRNA29097150
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of NCAM2 promoter22457795
D003471CuprizoneCuprizone results in decreased expression of NCAM2 mRNA26577399|2752363
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NCAM2 promoter23359474
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of NCAM2 mRNA28962523
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of NCAM2 promoter23359474
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NCAM2 mRNA22129741
D004221DisulfiramDisulfiram results in decreased expression of NCAM2 mRNA20530235
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of NCAM2 mRNA29097150
C039281furanfuran results in decreased expression of NCAM2 mRNA25539665
C039281furanfuran results in increased methylation of NCAM2 gene22079235
C004312glycidolglycidol results in decreased expression of NCAM2 mRNA24915197
C016517indole-3-carbinolindole-3-carbinol affects the expression of NCAM2 mRNA21396975
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of NCAM2 mRNA22129741
C029310lardlard results in decreased expression of NCAM2 mRNA26115784
C029310lardlard results in increased expression of NCAM2 mRNA26115784
D007854LeadLead affects the expression of NCAM2 mRNA28903495
C008261lead acetatelead acetate results in decreased expression of NCAM2 mRNA22609695
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of NCAM2 mRNA12057914
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of NCAM2 mRNA24810058
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of NCAM2 mRNA"29244179
D011441PropylthiouracilPropylthiouracil results in decreased expression of NCAM2 mRNA24780913
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of NCAM2 mRNA25879800
C016766sulforafansulforafan results in decreased expression of NCAM2 mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NCAM2 mRNA26377647
D013893ThiramThiram results in decreased expression of NCAM2 mRNA20530235
D014118Toxins, Biological"Toxins, Biological affects the expression of NCAM2 mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of NCAM2 mRNA20530235
D014212TretinoinTretinoin results in increased expression of NCAM2 mRNA21934132|2372400
D014241TrichloroethyleneTrichloroethylene results in increased methylation of NCAM2 gene27618143
D014415TunicamycinTunicamycin results in decreased expression of NCAM2 mRNA22378314
D014520UrethaneUrethane results in increased expression of NCAM2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NCAM2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of NCAM2 mRNA26272509|2800136
D014638VanadatesVanadates results in increased expression of NCAM2 mRNA22714537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042802identical protein binding-IPI21300289  
GO ID GO Term Qualifier Evidence PubMed
GO:0007158neuron cell-cell adhesion-TAS9226371  
GO:0007413axonal fasciculation-IEA-  
GO:0007608sensory perception of smell-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA-  
GO:0016021integral component of membrane-IEA-  
GO:0016604nuclear body-IDA-  
GO:0030424axon-IEA-  
GO:0043005neuron projection-IBA21873635  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa05020Prion diseases
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal