Gene: CHST11

50515
C4ST|C4ST-1|C4ST1|HSA269537
carbohydrate sulfotransferase 11
protein-coding
12q23.3
Ensembl:ENSG00000171310 MIM:610128 Vega:OTTHUMG00000169803 UniprotKB:Q9NPF2
NG_029810.1
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.645e-1 (AD)  1.935e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1704904chr12:104548608 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs11112082chr12:104497619 (GRCh38.p7)G>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPRZ10.828
THBS40.776
MPZL10.764
CPNE30.759
PCDHGC30.752
ARHGAP310.749
ARHGEF400.747
S1PR10.742
ZFP36L10.74
PITPNC10.738

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.519
OR4F29-0.449
ADTRP-0.359
TRABD2A-0.343
ABCC12-0.338
MYCNOS-0.338
E2F1-0.336
NRG1-0.331
CALHM1-0.325
PPEF1-0.322

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CHST11 mRNA19933214
D000082AcetaminophenAcetaminophen results in increased expression of CHST11 mRNA29067470
D020106AcrylamideAcrylamide affects the expression of CHST11 mRNA28959563
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CHST11 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHST11 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CHST11 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CHST11 mRNA21569818
C006780bisphenol Abisphenol A results in decreased expression of CHST11 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CHST11 gene28505145
D000069286BortezomibBortezomib results in decreased expression of CHST11 mRNA20977926
C018475butyraldehydebutyraldehyde results in increased expression of CHST11 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of CHST11 mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CHST11 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHST11 mRNA20938992
D016572CyclosporineCyclosporine results in increased expression of CHST11 mRNA20106945
D002945CisplatinCisplatin results in decreased expression of CHST11 mRNA19561079
D004041Dietary FatsDietary Fats results in decreased expression of CHST11 mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of CHST11 mRNA16002434
D004811EpichlorohydrinCHST11 gene SNP affects the susceptibility to Epichlorohydrin25622337
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CHST11 mRNA22079256
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHST11 mRNA20938992
C409722hexaconazolehexaconazole results in increased expression of CHST11 mRNA22045034
D017313FenretinideFenretinide results in increased expression of CHST11 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CHST11 mRNA25613284
D007854LeadLead affects the splicing of CHST11 mRNA28903495
C031895lead chromatelead chromate results in decreased expression of CHST11 mRNA23584427
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHST11 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of CHST11 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CHST11 mRNA26011545
C517284monomethyl phthalatemonomethyl phthalate affects the expression of CHST11 mRNA26924002
C523799MRK 003CHST11 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CHST11 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CHST11 mRNA"25554681
D009532NickelNickel results in increased expression of CHST11 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of CHST11 mRNA22714537
D000073878Palm OilPalm Oil results in decreased expression of CHST11 mRNA18042831
D010634PhenobarbitalPhenobarbital affects the expression of CHST11 mRNA19159669
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CHST11 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CHST11 mRNA22079256|2271453
D011374ProgesteroneProgesterone results in increased expression of CHST11 mRNA21540246
C005556propionaldehydepropionaldehyde results in increased expression of CHST11 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of CHST11 mRNA24780913
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of CHST11 mRNA15585670
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of CHST11 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of CHST11 mRNA23221170
C017947sodium arsenitesodium arsenite affects the methylation of CHST11 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of CHST11 mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CHST11 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CHST11 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CHST11 mRNA25613284
D014212TretinoinTretinoin results in increased expression of CHST11 mRNA23724009
C057693troglitazonetroglitazone results in increased expression of CHST11 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of CHST11 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of CHST11 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of CHST11 mRNA22045034
D014638VanadatesVanadates results in increased expression of CHST11 mRNA22714537
C029297vinylidene chloridevinylidene chloride results in decreased expression of CHST11 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001537N-acetylgalactosamine 4-O-sulfotransferase activity-IDA11056388  
GO:0047756chondroitin 4-sulfotransferase activity-IDA11056388  
GO:0047756chondroitin 4-sulfotransferase activity-TAS-  
GO:0050659N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002063chondrocyte development-IEA-  
GO:0007585respiratory gaseous exchange-IEA-  
GO:0009791post-embryonic development-IEA-  
GO:0016051carbohydrate biosynthetic process-IEA-  
GO:0030206chondroitin sulfate biosynthetic process-IDA11056388  
GO:0030206chondroitin sulfate biosynthetic process-TAS-  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-IEA-  
GO:0033037polysaccharide localization-IEA-  
GO:0036342post-anal tail morphogenesis-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0042733embryonic digit morphogenesis-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0048589developmental growth-IEA-  
GO:0048703embryonic viscerocranium morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-NAS11056388  
KEGG ID KEGG Term
hsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
hsa00920Sulfur metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-2022870Chondroitin sulfate biosynthesisTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal