Gene: PDE4B

5142
DPDE4|PDEIVB
phosphodiesterase 4B
protein-coding
1p31.3
Ensembl:ENSG00000184588 MIM:600127 Vega:OTTHUMG00000009088 UniprotKB:Q07343
NG_029038.1
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.423e-1 (AD)  5.194e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12728294chr1:66274784 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs6700403chr1:66269918 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs2485381chr1:66162049 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17128103chr1:65903182 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBXN40.836
COPB10.83
TMED100.828
MDM20.823
PGM30.822
COPB20.822
SEC23B0.82
LMAN10.82
CDC42SE10.819
CD1640.813

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.577
OR4F29-0.546
RERGL-0.183
HES5-0.178
SPRR2A-0.169
REM1-0.166
PTGDR2-0.162
STON1-GTF2A1L-0.151
TDGF1-0.149
FEV-0.146

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00131Adenosine monophosphateSmall Molecule61-19-8Approved|Investigational|NutraceuticalTarget
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
DB00277TheophyllineSmall Molecule58-55-9ApprovedTarget
DB00651DyphyllineSmall Molecule479-18-5ApprovedTarget
DB00806PentoxifyllineSmall Molecule6493-05-6Approved|InvestigationalTarget
DB00824EnprofyllineSmall Molecule41078-02-8Approved|InvestigationalTarget
DB01088IloprostSmall Molecule78919-13-8Approved|InvestigationalTarget
DB01113PapaverineSmall Molecule58-74-2Approved|InvestigationalTarget
DB01412TheobromineSmall Molecule83-67-0Approved|InvestigationalTarget
DB01427AmrinoneSmall Molecule60719-84-8ApprovedTarget
DB01647DaxalipramSmall Molecule189940-24-7ExperimentalTarget
DB01656RoflumilastSmall Molecule162401-32-3ApprovedTarget
DB01791PiclamilastSmall Molecule144035-83-6ExperimentalTarget
DB01954RolipramSmall Molecule61413-54-5InvestigationalTarget
DB019593,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterSmall MoleculeExperimentalTarget
DB02660FilaminastSmall Molecule141184-34-1ExperimentalTarget
DB033498-Bromo-Adenosine-5'-MonophosphateSmall MoleculeExperimentalTarget
DB03606(S)-RolipramSmall Molecule85416-73-5ExperimentalTarget
DB038071-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterSmall MoleculeExperimentalTarget
DB03849CilomilastSmall Molecule153259-65-5InvestigationalTarget
DB04149(R)-RolipramSmall Molecule85416-75-7ExperimentalTarget
DB04530S,S-(2-Hydroxyethyl)ThiocysteineSmall MoleculeExperimentalTarget
DB05219CrisaboroleSmall Molecule906673-24-3Approved|InvestigationalTarget
DB05266IbudilastSmall Molecule50847-11-5Approved|InvestigationalTarget
DB05676ApremilastSmall Molecule608141-41-9Approved|InvestigationalTarget
DB069091-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamideSmall MoleculeExperimentalTarget
DB082994-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acidSmall MoleculeExperimentalTarget
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
DB09283TrapidilSmall Molecule15421-84-8ApprovedTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione affects the expression of PDE4B mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PDE4B mRNA"28903501
C5544401-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester results in decreased activity of PDE4B protein20621091
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE4B mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PDE4B mRNA"27291303
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE4B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE4B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE4B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE4B mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PDE4B mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PDE4B mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDE4B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDE4B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4B mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PDE4B mRNA17562736
D000082AcetaminophenMAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PDE4B mRNA]18700144
D000242Cyclic AMP[Bresol results in decreased activity of PDE4B protein] which results in increased abundance of Cyclic AMP21854221
D000242Cyclic AMPCyclic AMP inhibits the reaction [DISC1 protein binds to PDE4B protein]16293762
D000242Cyclic AMP[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP21266552
D000242Cyclic AMP[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]21266552
D000242Cyclic AMPPDE4B protein results in increased metabolism of and results in decreased activity of Cyclic AMP18394866
D012436S-AdenosylmethionineS-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]21266552
D012436S-Adenosylmethionine[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP21266552
D012436S-Adenosylmethionine[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]21266552
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PDE4B gene27153756
D000420Albuterol[Albuterol co-treated with Rolipram] results in increased expression of PDE4B mRNA10763856
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of PDE4B mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PDE4B mRNA24449571
D001151ArsenicArsenic results in decreased expression of PDE4B mRNA16835338
D001151ArsenicArsenic results in decreased expression of PDE4B mRNA19654921
C006632arsenic trioxidearsenic trioxide results in decreased expression of PDE4B mRNA15761015
D001280AtrazineAtrazine results in decreased expression of PDE4B mRNA19541795
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDE4B mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDE4B mRNA21569818
D004958EstradiolEstradiol affects the expression of PDE4B mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of PDE4B mRNA20404318
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of PDE4B mRNA26186136
C006780bisphenol Abisphenol A results in increased expression of PDE4B mRNA21932408
C006780bisphenol Abisphenol A affects the expression of PDE4B mRNA25181051
C570562BresolBresol inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]21854221
C570562BresolBresol results in decreased activity of PDE4B protein21854221
C570562Bresol[Bresol results in decreased activity of PDE4B protein] which results in increased abundance of Cyclic AMP21854221
D002065BuspironeBuspirone results in decreased expression of PDE4B mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of PDE4B mRNA26079696
D000074262Canola OilCanola Oil metabolite results in increased expression of PDE4B mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PDE4B mRNA17484886
D002922CiguatoxinsCiguatoxins affects the expression of PDE4B mRNA18353800
C433247CilomilastCilomilast results in decreased activity of PDE4B protein11907180
D002927CimetidineCimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA]11131300
D003024ClozapineClozapine results in decreased expression of PDE4B protein20222156
D003024ClozapineClozapine results in increased expression of PDE4B mRNA18222493
D003024ClozapineClozapine results in increased expression of PDE4B protein18222493
D005576ColforsinColforsin results in increased expression of PDE4B mRNA15967414
C423222cotylenin Acotylenin A results in increased expression of PDE4B mRNA16129123
C030123coumarincoumarin results in decreased expression of PDE4B mRNA18480146
D003561CytarabineCytarabine results in increased expression of PDE4B mRNA21198554
C014347decitabinedecitabine affects the expression of PDE4B mRNA23300844
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of PDE4B mRNA17330099
D003703DemecolcineDemecolcine results in increased expression of PDE4B mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PDE4B mRNA21266533
D002945CisplatinCisplatin affects the expression of PDE4B mRNA23300844
D002945CisplatinCisplatin results in increased expression of PDE4B mRNA27594783
D004041Dietary FatsDietary Fats results in increased expression of PDE4B mRNA18042831
D002117CalcitriolCalcitriol results in increased expression of PDE4B mRNA16002434|2648566
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of PDE4B mRNA17374397
D004176DipyridamoleDipyridamole results in increased expression of PDE4B mRNA20711499
D004317DoxorubicinDoxorubicin results in increased expression of PDE4B mRNA19277126
C118739entinostatentinostat results in decreased expression of PDE4B mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDE4B mRNA"27188386
D000431EthanolPDE4B gene SNP affects the susceptibility to Ethanol18438686
D000431EthanolEthanol results in decreased expression of PDE4B mRNA20655511
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PDE4B mRNA23649840
D005047EtoposidePDE4B protein affects the susceptibility to Etoposide16217747
D005054EugenolEugenol results in increased expression of PDE4B mRNA17374397
C082360fipronilfipronil results in decreased expression of PDE4B mRNA23962444
D005473FluoxetineFluoxetine affects the expression of PDE4B mRNA12504921
D005473FluoxetineFluoxetine results in decreased expression of PDE4B protein20222156
D005473FluoxetineFluoxetine results in increased expression of PDE4B mRNA22291481
D005557FormaldehydeFormaldehyde results in decreased expression of PDE4B mRNA20655997|2766457
D005557FormaldehydeFormaldehyde results in increased expression of PDE4B mRNA23649840
C039281furanfuran results in decreased methylation of PDE4B gene22079235
C007834genipingenipin inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]22687549
D005839GentamicinsGentamicins results in increased expression of PDE4B mRNA22061828
D006046Gold[Gold co-treated with Polyethylene Glycols] results in increased expression of PDE4B mRNA19695318
D006632HistamineCimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA]11131300
D006632HistamineHistamine results in increased expression of PDE4B mRNA11131300
D017313FenretinideFenretinide results in increased expression of PDE4B mRNA28973697
C503753Indolinone AIndolinone A results in decreased expression of PDE4B mRNA15712243
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDE4B mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of PDE4B mRNA15956246
C051890irinotecanirinotecan results in decreased expression of PDE4B mRNA15956246
C051890irinotecanirinotecan affects the expression of PDE4B mRNA20097248
D0150561-Methyl-3-isobutylxanthine1-Methyl-3-isobutylxanthine results in increased expression of PDE4B mRNA20711499
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TRIM33 mutant form results in decreased expression of PDE4B mRNA]27432991
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDE4B mRNA23086925|2343069
C459562L-826,141"L-826,141 results in decreased activity of PDE4B protein"15901792
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of PDE4B mRNA alternative form"21748778
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PDE4B mRNA alternative form"21748778
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PDE4B mRNA"18930950
D008070LipopolysaccharidesBresol inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]21854221
D008070LipopolysaccharidesLipopolysaccharides affects the expression of PDE4B mRNA28070326
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PDE4B mRNA21854221
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of PDE4B mRNA]28070326
D008070Lipopolysaccharidesgenipin inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]22687549
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PDE4B mRNA20384571|2126655
D008070LipopolysaccharidesRolipram inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]20384571
D008070LipopolysaccharidesS-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]21266552
D008070Lipopolysaccharides[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP21266552
D008070Lipopolysaccharides[[S-Adenosylmethionine inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]] which results in increased abundance of Cyclic AMP] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]21266552
D008070Lipopolysaccharidesseptilin inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]20384571
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PDE4B mRNA25613284
D008094LithiumLithium results in decreased expression of PDE4B protein20222156
D018021Lithium ChlorideLithium Chloride results in decreased expression of PDE4B mRNA23527032
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PDE4B mRNA26378955
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PDE4B mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PDE4B mRNA26378955
C042720mercuric bromidemercuric bromide results in increased expression of PDE4B mRNA26272509
D008694MethamphetaminePDE4B gene SNP affects the susceptibility to Methamphetamine18316681
D008727MethotrexateMethotrexate affects the expression of PDE4B mRNA18502557
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of PDE4B protein"28790194
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PDE4B mRNA28001369
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of PDE4B mRNA"29244179
C001478N(6)-(delta(2)-isopentenyl)adenineN(6)-(delta(2)-isopentenyl)adenine results in increased expression of PDE4B mRNA16129123
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of PDE4B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PDE4B mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PDE4B mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PDE4B mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of PDE4B mRNA19812364
D009532NickelNickel results in increased expression of PDE4B mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of PDE4B mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of PDE4B mRNA16780908|1737439
C012655nimesulidenimesulide results in decreased expression of PDE4B mRNA24136188
C451724NVP ABE171NVP ABE171 results in decreased activity of PDE4B protein11907180
C507134ON 01910ON 01910 results in increased expression of PDE4B mRNA22351695
D010098OxycodoneOxycodone results in decreased expression of PDE4B mRNA23439660
D010100OxygenOxygen deficiency results in increased expression of PDE4B mRNA16373842
D010100OxygenSimvastatin inhibits the reaction [Oxygen deficiency results in increased expression of PDE4B mRNA]16373842
D010100OxygenOxygen results in increased expression of PDE4B protein18941502
D000073878Palm OilPalm Oil results in increased expression of PDE4B mRNA18042831
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PDE4B mRNA"25510870
D010634PhenobarbitalPhenobarbital results in decreased expression of PDE4B mRNA19270015
D010634PhenobarbitalPhenobarbital results in decreased expression of PDE4B mRNA19162173
D010656PhenylephrinePhenylephrine results in increased expression of PDE4B mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4B mRNA"27188386
C006253pirinixic acidpirinixic acid results in decreased expression of PDE4B mRNA18445702|2381119
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of PDE4B mRNA]28070326
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in increased expression of PDE4B mRNA19695318
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PDE4B mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of PDE4B mRNA21795739
D011374ProgesteroneProgesterone results in increased expression of PDE4B mRNA18497975
C424423RoflumilastRoflumilast results in decreased activity of PDE4B protein15901792
D020889Rolipram[Albuterol co-treated with Rolipram] results in increased expression of PDE4B mRNA10763856
D020889RolipramRolipram inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]20384571
C047352septilinseptilin inhibits the reaction [Lipopolysaccharides results in increased expression of PDE4B mRNA]20384571
C047352septilinseptilin results in decreased expression of PDE4B mRNA20384571
C009250sevofluranesevoflurane affects the expression of PDE4B mRNA15967596
D012822Silicon DioxideSilicon Dioxide results in increased expression of PDE4B mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PDE4B mRNA19073995
D012834SilverSilver results in decreased expression of PDE4B mRNA27131904
D019821SimvastatinSimvastatin inhibits the reaction [Oxygen deficiency results in increased expression of PDE4B mRNA]16373842
D012906SmokeSmoke results in increased expression of PDE4B mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of PDE4B mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of PDE4B mRNA21795629
D053260SootSoot results in increased expression of PDE4B mRNA26551751
D013311StreptozocinStreptozocin results in decreased expression of PDE4B mRNA25905778
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of PDE4B mRNA16214533
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PDE4B mRNA26378955
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PDE4B mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PDE4B mRNA26378955
C016766sulforafansulforafan results in increased expression of PDE4B mRNA26833863
D013629TamoxifenTamoxifen affects the expression of PDE4B mRNA14699072
D013629TamoxifenTamoxifen affects the expression of PDE4B mRNA20937368
D013739Testosterone[FSHB protein co-treated with Testosterone] results in increased expression of PDE4B mRNA18535249
D013739Testosterone[PRKACA protein mutant form co-treated with Testosterone] results in increased expression of PDE4B mRNA18535249
C004648testosterone enanthatetestosterone enanthate results in increased expression of PDE4B mRNA21427060|2560346
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDE4B mRNA26377647|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of PDE4B mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDE4B mRNA17337447|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDE4B mRNA22298810
D013752TetracyclineTetracycline results in increased expression of PDE4B mRNA16917069
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDE4B mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of PDE4B mRNA23557971|2776080
C052342topiramatetopiramate results in decreased expression of PDE4B mRNA16979414
C483909torcetrapibtorcetrapib results in increased expression of PDE4B mRNA23228038
C035964trequinsintrequinsin results in decreased activity of PDE4B protein15901792
D014212TretinoinTretinoin results in decreased expression of PDE4B mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PDE4B mRNA25549359
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of PDE4B mRNA"18930950
C080163trovafloxacintrovafloxacin results in decreased expression of PDE4B mRNA24136188
D014415TunicamycinTunicamycin results in decreased expression of PDE4B mRNA22378314
C406224valdecoxibvaldecoxib results in decreased expression of PDE4B mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of PDE4B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PDE4B mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in increased expression of PDE4B mRNA24383497|2800136
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PDE4B gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of PDE4B mRNA25423262
C025643vinclozolinvinclozolin affects the expression of PDE4B mRNA19015723
D014750VincristineVincristine results in increased expression of PDE4B mRNA23649840
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of PDE4B mRNA17330099
D015034Zinc OxideZinc Oxide analog results in decreased expression of PDE4B mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of PDE4B mRNA27215404
C088658zoledronic acidzoledronic acid results in decreased expression of PDE4B mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00041153',5'-cyclic-AMP phosphodiesterase activity-IDA17404263  
GO:00041153',5'-cyclic-AMP phosphodiesterase activity-IGI8413254  
GO:00041153',5'-cyclic-AMP phosphodiesterase activity-ISS-  
GO:00041153',5'-cyclic-AMP phosphodiesterase activity-TAS-  
GO:0030552cAMP binding-IGI8413254  
GO:0043015gamma-tubulin binding-IEA-  
GO:0044325ion channel binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001780neutrophil homeostasis-ISS-  
GO:0006198cAMP catabolic process-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0030593neutrophil chemotaxis-ISS-  
GO:0032729positive regulation of interferon-gamma production-IMP17404263  
GO:0032743positive regulation of interleukin-2 production-IMP17404263  
GO:0035690cellular response to drug-ISS-  
GO:0050852T cell receptor signaling pathway-IMP17404263  
GO:0050900leukocyte migration-ISS-  
GO:0071222cellular response to lipopolysaccharide-ISS-  
GO:0071872cellular response to epinephrine stimulus-ISS-  
GO:0086004regulation of cardiac muscle cell contraction-ISS-  
GO:1901841regulation of high voltage-gated calcium channel activity-ISS-  
GO:1901898negative regulation of relaxation of cardiac muscle-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000930gamma-tubulin complex-IEA-  
GO:0005813centrosome-IEA-  
GO:0005829cytosol-TAS-  
GO:0005891voltage-gated calcium channel complex-ISS-  
GO:0008021synaptic vesicle-IEA-  
GO:0014069postsynaptic density-IEA-  
GO:0030018Z disc-ISS-  
GO:0043197dendritic spine-IEA-  
GO:0060076excitatory synapse-IEA-  
KEGG ID KEGG Term
hsa00230Purine metabolism
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-180024DARPP-32 eventsTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28937693Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117). (2017 Oct)Clarke TKMol Psychiatry
16814262Chronic nicotine doses down-regulate PDE4 isoforms that are targets of antidepressants in adolescent female rats. (2007 Jan 1)Polesskaya OOBiol Psychiatry