Gene: CDK14

5218
PFTAIRE1|PFTK1
cyclin dependent kinase 14
protein-coding
7q21.13
Ensembl:ENSG00000058091 MIM:610679 Vega:OTTHUMG00000023649 UniprotKB:O94921
NC_000007.14
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.650e-1 (AD)  3.617e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs803174chr7:91165480 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs705362chr7:91153219 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SNAP910.978
TRIM370.977
SYT10.975
PRKCE0.975
CADPS0.974
ATP6V1A0.973
GABRA10.973
KIF3A0.97
MAP2K40.97
OPCML0.97

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.541
HEY2-0.537
RAB13-0.53
RNF135-0.526
REST-0.523
CMTM3-0.517
WWTR1-0.516
RAI14-0.516
TGIF1-0.515
CNN2-0.513

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of CDK14 mRNA21983209
D000082AcetaminophenAcetaminophen results in decreased expression of CDK14 mRNA21420995
D020106AcrylamideAcrylamide results in decreased expression of CDK14 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CDK14 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CDK14 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CDK14 gene27153756
D000452AldrinAldrin results in increased expression of CDK14 mRNA18579281
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CDK14 mRNA24449571
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of CDK14 mRNA15894712
C015001arsenitearsenite results in increased expression of CDK14 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDK14 mRNA20064835|2010694
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of CDK14 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDK14 mRNA15894712|2156981
D004958Estradiol[Dieldrin co-treated with Estradiol] results in increased expression of CDK14 mRNA23041725
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CDK14 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of CDK14 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of CDK14 mRNA17484886
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDK14 mRNA20938992
C031180chrysenechrysene results in decreased expression of CDK14 mRNA26377693
D016572CyclosporineCyclosporine results in decreased expression of CDK14 mRNA22147139|2798913
D016572CyclosporineCyclosporine results in decreased methylation of CDK14 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CDK14 mRNA23914054
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CDK14 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CDK14 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CDK14 mRNA22023808
D004026Dieldrin[Dieldrin co-treated with Estradiol] results in increased expression of CDK14 mRNA23041725
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDK14 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDK14 mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDK14 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of CDK14 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of CDK14 mRNA19167457
C001277geldanamycingeldanamycin results in increased expression of CDK14 mRNA26705709
D017313FenretinideFenretinide results in decreased expression of CDK14 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CDK14 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CDK14 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CDK14 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CDK14 mRNA27392435
D007649KetamineKetamine results in decreased expression of CDK14 mRNA20080153
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of CDK14 mRNA27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of CDK14 mRNA27188386
D008713MethimazoleMethimazole results in decreased expression of CDK14 mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CDK14 mRNA20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CDK14 mRNA"20188158
D009151Mustard GasMustard Gas affects the expression of CDK14 mRNA15651846
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CDK14 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of CDK14 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of CDK14 mRNA22714537
C025589ochratoxin Aochratoxin A results in decreased acetylation of CDK14 promoter29098329
C025589ochratoxin A[ochratoxin A results in decreased acetylation of CDK14 promoter] which results in decreased expression of CDK14 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in decreased expression of CDK14 mRNA29098329
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CDK14 mRNA25729387
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CDK14 mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of CDK14 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in decreased expression of CDK14 mRNA22504374
D012906SmokeSmoke analog results in decreased expression of CDK14 mRNA25680692
D012906SmokeSmoke analog results in decreased expression of CDK14 protein25680692
D012906SmokeSmoke analog results in decreased expression of CDK14 mRNA25680692
D012906SmokeSmoke analog results in decreased expression of CDK14 protein25680692
C016104sodium bichromatesodium bichromate affects the expression of CDK14 mRNA22110744
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDK14 mRNA24680724
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDK14 mRNA17942748
D013849ThimerosalThimerosal affects the expression of CDK14 mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CDK14 mRNA25680692
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CDK14 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of CDK14 mRNA23228038
D014212TretinoinTretinoin results in decreased expression of CDK14 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of CDK14 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of CDK14 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CDK14 mRNA26272509
D014635Valproic AcidValproic Acid results in decreased methylation of CDK14 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CDK14 gene25560391
C111237vorinostatvorinostat results in decreased expression of CDK14 mRNA27188386
C070417Win 55212-2Win 55212-2 results in increased expression of CDK14 mRNA12237329

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004693cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0004693cyclin-dependent protein serine/threonine kinase activity-IMP19524571  20059949  
GO:0005515protein binding-IPI16775625  17517622  19524571  22939624  23602568  
GO:0005524ATP binding-IEA-  
GO:0030332cyclin binding-IBA21873635  
GO:0030332cyclin binding-IPI19524571  20059949  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-IDA20059949  
GO:0006468protein phosphorylation-IBA21873635  
GO:0006468protein phosphorylation-IEA-  
GO:0016055Wnt signaling pathway-IEA-  
GO:0051301cell division-IEA-  
GO:0051726regulation of cell cycle-IEA-  
GO:0060828regulation of canonical Wnt signaling pathway-IDA20059949  
GO ID GO Term Qualifier Evidence PubMed
GO:0000308cytoplasmic cyclin-dependent protein kinase holoenzyme complex-IDA19524571  20059949  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS9202329  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA19524571  20059949  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal