Gene: RIN2

54453
MACS|RASSF4
Ras and Rab interactor 2
protein-coding
20p11.23
Ensembl:ENSG00000132669 MIM:610222 Vega:OTTHUMG00000031996 UniprotKB:Q8WYP3
NG_016310.1
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.869e-1 (AD)  4.657e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11908323chr20:19826835 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs6081761chr20:19826064 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ITGB50.867
NFIA0.866
PARD3B0.853
CYBRD10.853
PON20.851
PDLIM50.847
HDAC10.84
LIX1L0.84
S1PR10.839
ARHGAP310.838

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRG3-0.564
CALHM1-0.56
PAQR9-0.557
HAS1-0.556
RTP1-0.552
MCHR1-0.548
KCNB2-0.538
IL12RB2-0.538
ANKRD34C-0.536
RHO-0.533

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of RIN2 mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of RIN2 mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RIN2 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of RIN2 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RIN2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of RIN2 mRNA21420995|2906747
D001379AzathioprineAzathioprine results in increased expression of RIN2 mRNA22623647
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of RIN2 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of RIN2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of RIN2 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RIN2 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RIN2 mRNA21632981|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RIN2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RIN2 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of RIN2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RIN2 gene28505145
D002185CannabidiolCannabidiol results in decreased expression of RIN2 mRNA21542829
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RIN2 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of RIN2 mRNA23052192
D019327Copper SulfateCopper Sulfate results in increased expression of RIN2 mRNA18579281
D016572CyclosporineCyclosporine affects the expression of RIN2 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of RIN2 mRNA21632981|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RIN2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RIN2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of RIN2 mRNA21603599
D002117CalcitriolCalcitriol results in increased expression of RIN2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of RIN2 mRNA21592394
D004237DiuronDiuron results in decreased expression of RIN2 mRNA21551480
C118739entinostatentinostat results in decreased expression of RIN2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RIN2 mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of RIN2 mRNA23649840
D005485FlutamideFlutamide results in decreased expression of RIN2 mRNA24136188
C065180fluvastatin[zoledronic acid co-treated with fluvastatin] results in increased expression of RIN2 mRNA16996129
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RIN2 gene20938992
D005557FormaldehydeFormaldehyde results in increased expression of RIN2 mRNA23649840
D005897GlafenineGlafenine results in decreased expression of RIN2 mRNA24136188
D017313FenretinideFenretinide results in increased expression of RIN2 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RIN2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RIN2 mRNA24796395|2530787
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of RIN2 mRNA25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of RIN2 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of RIN2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RIN2 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of RIN2 mRNA19465457
C030589methylmercury cysteinemethylmercury cysteine results in decreased expression of RIN2 mRNA19465457
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of RIN2 mRNA23649840
C523799MRK 003RIN2 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of RIN2 mRNA"25554681
C012655nimesulidenimesulide results in decreased expression of RIN2 mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of RIN2 mRNA25729387
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of RIN2 mRNA23948077
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RIN2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of RIN2 mRNA18301758
D011794QuercetinQuercetin affects the expression of RIN2 mRNA21632981
C010327salinomycinsalinomycin results in decreased expression of RIN2 mRNA19682730
D012822Silicon DioxideSilicon Dioxide results in decreased expression of RIN2 mRNA19073995
C009277sodium arsenatesodium arsenate results in increased expression of RIN2 mRNA21795629
C016104sodium bichromatesodium bichromate results in decreased expression of RIN2 mRNA17685462
D053260SootSoot results in increased expression of RIN2 mRNA26551751
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of RIN2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of RIN2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of RIN2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RIN2 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of RIN2 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of RIN2 mRNA25729387
D014212TretinoinTretinoin results in increased expression of RIN2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of RIN2 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased methylation of RIN2 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of RIN2 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of RIN2 mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of RIN2 mRNA29024780
D014520UrethaneUrethane results in decreased expression of RIN2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of RIN2 mRNA29154799
D014635Valproic AcidValproic Acid results in decreased methylation of RIN2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of RIN2 mRNA26272509
D014635Valproic AcidValproic Acid affects the expression of RIN2 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the methylation of RIN2 gene25560391
C025643vinclozolinvinclozolin affects the expression of RIN2 mRNA19015723
C088658zoledronic acid[zoledronic acid co-treated with fluvastatin] results in increased expression of RIN2 mRNA16996129

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005096GTPase activator activity-IEA-  
GO:0017112Rab guanyl-nucleotide exchange factor activity-NAS11733506  
GO:0017112Rab guanyl-nucleotide exchange factor activity-TAS-  
GO:0030695GTPase regulator activity-NAS1849280  
GO ID GO Term Qualifier Evidence PubMed
GO:0006897endocytosis-IEA-  
GO:0007264small GTPase mediated signal transduction-NAS1849280  
GO:0043547positive regulation of GTPase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal