Gene: CDKAL1

54901
-
CDK5 regulatory subunit associated protein 1 like 1
protein-coding
6p22.3
Ensembl:ENSG00000145996 MIM:611259 Vega:OTTHUMG00000014340 UniprotKB:Q5VV42
NG_021195.1
PubMed|SNP Mapped
3   ANCO-SNPs
ND|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.511e-2 (AD)  6.844e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12664021chr6:20760849 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs9295475chr6:20652534 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs2206579chr6:20625403 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15646123chr6:20954499CDKAL1Gene body4.875e-4Alcohol use disorders26763658
cg18954479chr6:20834224CDKAL11.600e-10Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMAD40.819
NUP2050.804
SUPT20H0.797
METTL140.797
SSR10.794
NIPBL0.793
ABCB70.79
ERP440.787
PGM30.786
CNOT60.785

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.505
OR4F29-0.47
CRH-0.243
PRSS56-0.184
CYP1A1-0.183
SPRR2A-0.177
HES5-0.175
HCRTR1-0.173
MYLK2-0.171
EDN3-0.166

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CDKAL1 mRNA"18648102
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CDKAL1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CDKAL1 mRNA21632981|2164198
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CDKAL1 mRNA19770486
D047310ApigeninApigenin results in increased expression of CDKAL1 mRNA22359648
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDKAL1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDKAL1 mRNA19770486|2171566
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CDKAL1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDKAL1 mRNA"20382639|2623829
C044887beta-methylcholinebeta-methylcholine affects the expression of CDKAL1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of CDKAL1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of CDKAL1 mRNA21786754
C018475butyraldehydebutyraldehyde results in decreased expression of CDKAL1 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDKAL1 gene20938992
D016572CyclosporineCyclosporine results in increased expression of CDKAL1 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CDKAL1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CDKAL1 mRNA24280081|2739243
D002945CisplatinCisplatin results in decreased expression of CDKAL1 mRNA24280081
D004041Dietary FatsDietary Fats results in decreased expression of CDKAL1 mRNA18042831
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in decreased expression of CDKAL1 mRNA21852083
D004126DimethylformamideDimethylformamide results in increased expression of CDKAL1 mRNA22169935
D004147DioxinsDioxins affects the expression of CDKAL1 mRNA20463971
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of CDKAL1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDKAL1 gene20938992
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of CDKAL1 mRNA18951874
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CDKAL1 mRNA27392435
C008261lead acetatelead acetate results in increased expression of CDKAL1 mRNA21829687
C045463leflunomideleflunomide results in increased expression of CDKAL1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of CDKAL1 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CDKAL1 gene20938992
D008727MethotrexateMethotrexate affects the expression of CDKAL1 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CDKAL1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CDKAL1 mRNA"26251327
D008777MethyltestosteroneMethyltestosterone results in decreased expression of CDKAL1 mRNA29191790
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CDKAL1 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of CDKAL1 mRNA18042831
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CDKAL1 protein26879310
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CDKAL1 mRNA19710929
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of CDKAL1 mRNA21334430
D011192Potassium DichromatePotassium Dichromate results in decreased expression of CDKAL1 protein23718831
D011794QuercetinQuercetin results in decreased expression of CDKAL1 mRNA21632981
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in decreased expression of CDKAL1 mRNA21852083
D012402RotenoneRotenone results in decreased expression of CDKAL1 mRNA19013527
C004648testosterone enanthatetestosterone enanthate affects the expression of CDKAL1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDKAL1 mRNA21570461
D013893ThiramThiram results in decreased expression of CDKAL1 mRNA20530235
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CDKAL1 mRNA25729387
D015032ZincZinc deficiency results in increased expression of CDKAL1 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005515protein binding-IPI25416956  
GO:0035596methylthiotransferase activity-IBA21873635  
GO:0035598N6-threonylcarbomyladenosine methylthiotransferase activity-EXP20584901  
GO:0035598N6-threonylcarbomyladenosine methylthiotransferase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO:00515394 iron, 4 sulfur cluster binding-IEA-  
GO:0061712tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006400tRNA modification-TAS-  
GO:0008150biological_process-ND-  
GO:0035600tRNA methylthiolation-IBA21873635  
GO:0035600tRNA methylthiolation-IEA-  
GO:1990145maintenance of translational fidelity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005791rough endoplasmic reticulum-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-6782315tRNA modification in the nucleus and cytosolTAS
R-HSA-72306tRNA processingTAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23202124New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. (2013 Jan)Horikoshi MNat Genet
22216278Large scale association analysis identifies three susceptibility loci for coronary artery disease. (2011)Saade SPLoS One
19020324Clinical risk factors, DNA variants, and the development of type 2 diabetes. (2008 Nov 20)Lyssenko VN Engl J Med
25516658Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan. (2014 Dec 14)Kuruma SWorld J Gastroenterol
19422935Genetic risk profiling and prediction of disease course in Crohn's disease patients. (2009 Sep)Henckaerts LClin Gastroenterol Hepatol