Gene: CCDC91

55297
HSD8|p56
coiled-coil domain containing 91
protein-coding
12p11.22
Ensembl:ENSG00000123106 MIM:617366 Vega:OTTHUMG00000169141 UniprotKB:Q7Z6B0
NC_000012.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.942e-1 (AD)  5.181e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10506030chr12:28362948 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6487673chr12:28285474 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCOC0.944
PJA20.94
PRKAR1A0.933
ADSS0.931
STX70.931
UCHL50.931
FAM98B0.93
AP1AR0.927
ACTR20.925
SLC25A460.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.563
OR4F29-0.553
CSAG1-0.388
KCNK5-0.363
EVC2-0.348
MTRNR2L10-0.346
RHOD-0.335
SYDE1-0.334
EYA2-0.33
MTRNR2L8-0.329

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCDC91 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCDC91 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 affects the expression of CCDC91 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CCDC91 mRNA21632981|2210060
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CCDC91 gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of CCDC91 protein26072098
D001151ArsenicArsenic affects the methylation of CCDC91 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CCDC91 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CCDC91 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CCDC91 mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of CCDC91 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CCDC91 gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of CCDC91 protein28903499
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CCDC91 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CCDC91 mRNA20938992
D016572CyclosporineCyclosporine results in increased expression of CCDC91 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased expression of CCDC91 mRNA19770486
C000944dicrotophosdicrotophos results in decreased expression of CCDC91 mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of CCDC91 mRNA"22485181
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of CCDC91 mRNA22079256
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CCDC91 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CCDC91 mRNA17555576
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CCDC91 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of CCDC91 mRNA19167457
C544151jinfukangjinfukang results in decreased expression of CCDC91 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of CCDC91 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CCDC91 mRNA26272509
D008774MethylphenidateMethylphenidate results in decreased expression of CCDC91 mRNA22470460
C028007nickel monoxidenickel monoxide results in decreased expression of CCDC91 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of CCDC91 mRNA25729387
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of CCDC91 mRNA28973697
C006253pirinixic acidpirinixic acid results in increased expression of CCDC91 mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CCDC91 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CCDC91 mRNA22079256
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of CCDC91 mRNA"26680231
D013629TamoxifenTamoxifen affects the expression of CCDC91 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CCDC91 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CCDC91 mRNA21215274
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of CCDC91 mRNA25729387
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CCDC91 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of CCDC91 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CCDC91 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of CCDC91 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CCDC91 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of CCDC91 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of CCDC91 mRNA29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CCDC91 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015031protein transport-IEA-  
GO:0090160Golgi to lysosome transport-IBA21873635  
GO:0090160Golgi to lysosome transport-IMP17596511  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005794Golgi apparatus-IDA-  
GO:0005802trans-Golgi network-IBA21873635  
GO:0005802trans-Golgi network-IDA17596511  
GO:0005829cytosol-IEA-  
GO:0016020membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal