Gene: MCTP2

55784
-
multiple C2 and transmembrane domain containing 2
protein-coding
15q26.2
Ensembl:ENSG00000140563 MIM:616297 Vega:OTTHUMG00000171751 UniprotKB:Q6DN12
NC_000015.10
SNP Mapped
5   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.493e-2 (AD)  2.360e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1048048chr15:94481531 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs1368839chr15:94417126 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10520754chr15:94416180 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3743307chr15:94341751 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4328383chr15:94320608 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEMA3E0.83
DACH10.789
FOXP20.754
TNIP30.747
FILIP10.745
THEMIS0.738
NPFFR20.736
SMYD10.714
CYP26A10.709
GRIK30.697

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OAF-0.381
TFAP2C-0.381
ASB4-0.38
RXRG-0.38
RLBP1-0.371
ENDOU-0.37
MSI1-0.366
CXCL14-0.364
C1QL2-0.364
RFX2-0.36

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCTP2 mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of MCTP2 mRNA"19095052
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MCTP2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MCTP2 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MCTP2 mRNA24449571
C006780bisphenol Abisphenol A results in increased expression of MCTP2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of MCTP2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MCTP2 gene28505145
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MCTP2 mRNA20971185
D005557FormaldehydeFormaldehyde results in decreased expression of MCTP2 mRNA23649840
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MCTP2 mRNA25613284
D048628KetolidesKetolides analog results in increased expression of MCTP2 mRNA24967691
D008727MethotrexateMethotrexate results in decreased expression of MCTP2 mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MCTP2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MCTP2 mRNA"25554681|2562005
D009532NickelNickel results in increased expression of MCTP2 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of MCTP2 mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MCTP2 mRNA20971185
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of MCTP2 mRNA19095052
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MCTP2 mRNA22714537
D012822Silicon DioxideSilicon Dioxide analog affects the expression of MCTP2 mRNA23806026
C017947sodium arsenitesodium arsenite results in increased expression of MCTP2 mRNA22714537
C016766sulforafansulforafan results in increased expression of MCTP2 mRNA26833863
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MCTP2 mRNA25613284
D019772TopotecanMCTP2 protein affects the susceptibility to Topotecan16217747
D014212TretinoinTretinoin results in decreased expression of MCTP2 mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of MCTP2 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of MCTP2 mRNA24383497
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MCTP2 gene25560391
C111237vorinostatvorinostat results in increased expression of MCTP2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IBA21873635  
GO:0005509calcium ion binding-IDA15528213  
GO:0005544calcium-dependent phospholipid bindingNOTIDA15528213  
GO ID GO Term Qualifier Evidence PubMed
GO:0007275multicellular organism development-IEA-  
GO:0019722calcium-mediated signaling-NAS15528213  
GO:0046928regulation of neurotransmitter secretion-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IBA21873635  
GO:0016021integral component of membrane-IDA15528213  
GO:0030672synaptic vesicle membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal