Gene info: ID 5581

Gene: PRKCE

GENE ID: 5581

Synonyms: PKCE|nPKC-epsilon

Description: protein kinase C epsilon

Gene type: protein-coding

Location: 2p21

dbXrefs: Ensembl:ENSG00000171132 MIM:176975 Vega:OTTHUMG00000128817 UniprotKB:Q02156

RefSeq: NC_000002.12

Retrived from: PubMed|SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: CD|ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.115e-1 (AD) 4.494e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs2345955	chr2:46093741 (GRCh38.p7)	C>T	nicotine dependence	SNV(Single Nucleotide Variation)
rs1470598	chr2:46042428 (GRCh38.p7)	A>G	nicotine dependence	SNV(Single Nucleotide Variation)
rs2595211	chr2:45979613 (GRCh38.p7)	T>A / T>G	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CADPS	0.979
DLGAP1	0.978
GABRA1	0.977
HCN1	0.977
SYT1	0.976
CDK14	0.975
SV2B	0.974
SNAP91	0.974
NELL2	0.973
AAK1	0.973

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CSAG1	-0.593
RNF135	-0.582
HEY2	-0.555
MYL3	-0.553
RAB13	-0.553
REST	-0.548
YES1	-0.547
CMTM3	-0.541
WWTR1	-0.54
RAI14	-0.537

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB06064	KAI-1455	Small Molecule	-	Investigational	Target
DB00675	Tamoxifen	Small Molecule	10540-29-1	Approved	Target

ID	Drug Name	Action	PubMed
C521406	1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane	1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]	20723002
C521406	1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane	1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein]	20723002
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRKCE mRNA"	25510870
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PRKCE mRNA"	21394737
C505456	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKCE protein]	16716347
C061282	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine affects the localization of and results in increased activity of PRKCE protein	12590138
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRKCE mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRKCE mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRKCE mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRKCE mRNA"	25510870
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PRKCE mRNA"	21346803
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of PRKCE mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCE mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCE mRNA"	27188386
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of PRKCE mRNA"	21346803
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCE mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCE mRNA"	27188386
D000079	Acetaldehyde	PRKCE protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]]	17991733
D000079	Acetaldehyde	PRKCE protein affects the reaction [EGF protein results in decreased susceptibility to Acetaldehyde]	17991733
D000082	Acetaminophen	Acetaminophen inhibits the reaction [F2 protein affects the localization of PRKCE protein]	21811393
D000082	Acetaminophen	Acetaminophen inhibits the reaction [KNG1 protein affects the localization of PRKCE protein]	21811393
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [NGF protein results in increased localization of and results in increased activity of PRKCE protein]	18375950
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PRKCE mRNA	21641981\|2210060
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of PRKCE gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PRKCE mRNA	19770486
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of PRKCE mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PRKCE mRNA	16483693
C061640	arjunolic acid	arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCE protein]	19682444
D001151	Arsenic	Arsenic affects the methylation of PRKCE gene	25304211
C006632	arsenic trioxide	arsenic trioxide affects the localization of PRKCE protein	18294404
C006632	arsenic trioxide	arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCE protein]	18294404
D001241	Aspirin	Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PRKCE protein]	17644113
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PRKCE mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PRKCE mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PRKCE mRNA	22316170
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PRKCE mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PRKCE mRNA	19770486\|2222880
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PRKCE mRNA"	17944540
D001599	Berberine	arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCE protein]	18294404
D001599	Berberine	Berberine results in decreased activity of and affects the localization of PRKCE protein	18294404
D001599	Berberine	Berberine results in decreased activity of PRKCE protein	18294404
D004958	Estradiol	Estradiol results in increased expression of PRKCE mRNA	21795739
D004958	Estradiol	Estradiol results in increased expression of PRKCE mRNA	25210133
C088060	bisindolylmaleimide	bisindolylmaleimide results in decreased activity of PRKCE protein	18375950
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of PRKCE mRNA]	28780155
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in decreased expression of PRKCE mRNA	28780155
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [PRKCE protein binds to STAT3 protein]]	24496235
C006780	bisphenol A	bisphenol A results in decreased expression of PRKCE mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of PRKCE mRNA	12075121\|2909715
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of and results in increased activity of PRKCE protein	11118818
D019328	Buthionine Sulfoximine	Cycloheximide inhibits the reaction [Buthionine Sulfoximine results in increased expression of PRKCE protein]	11118818
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of PRKCE mRNA	27509014
D020122	tert-Butylhydroperoxide	PRKCE protein affects the reaction [tert-Butylhydroperoxide results in decreased uptake of rubidium chloride]	14570699
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide affects the localization of PRKCE protein	14570699
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased phosphorylation of PRKCE protein	14570699
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRKCE mRNA	20360939
D002118	Calcium	PRKCE protein affects the susceptibility to Calcium	11245615
D002118	Calcium	Calcium results in increased phosphorylation of PRKCE protein	21562303
D002118	Calcium	chelerythrine inhibits the reaction [Calcium results in increased phosphorylation of PRKCE protein]	21562303
D002118	Calcium	PRKCE protein affects the reaction [F2RL1 protein promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased abundance of Calcium]]	16793902
D002118	Calcium	PRKCE protein affects the reaction [Oxygen deficiency results in increased abundance of Calcium]	17087917
D002118	Calcium	PRKCE protein affects the susceptibility to Calcium	15242976
D002211	Capsaicin	PRKCE protein affects the reaction [F2RL1 protein promotes the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased abundance of Calcium]]	16793902
C043211	carvedilol	carvedilol results in increased activity of PRKCE protein	16782078
C016299	chelerythrine	chelerythrine inhibits the reaction [Calcium results in increased phosphorylation of PRKCE protein]	21562303
C016299	chelerythrine	[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine	12700091
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) affects the localization of PRKCE protein	15475174
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of PRKCE mRNA	18668222
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of PRKCE mRNA	19368821
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PRKCE mRNA	27858113
D002996	Clomiphene	Clomiphene affects the localization of PRKCE protein	9714066
D003024	Clozapine	Clozapine results in increased expression of PRKCE mRNA	15860345
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PRKCE mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in increased oxidation of and results in increased activity of PRKCE protein	18375950
C018021	cobaltous chloride	PRKCE protein promotes the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of CREB1 protein]	18375950
C018021	cobaltous chloride	PRKCE protein promotes the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]	18375950
C018021	cobaltous chloride	PRKCE protein promotes the reaction [cobaltous chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]	18375950
C018021	cobaltous chloride	PRKCE protein promotes the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]	18375950
D003042	Cocaine	Cocaine affects the expression of PRKCE mRNA	20187946
D003042	Cocaine	Cocaine results in decreased expression of PRKCE protein	15677681
D003042	Cocaine	Cocaine results in decreased phosphorylation of PRKCE protein	15677681
C513821	CPU0213	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]	20307649
C513821	CPU0213	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein]	20307649
C513821	CPU0213	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein modified form]	20307649
D003471	Cuprizone	Cuprizone results in decreased expression of PRKCE mRNA	26577399
D003474	Curcumin	Curcumin analog results in decreased expression of PRKCE mRNA	26409325
D003474	Curcumin	Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]	17148446
D003474	Curcumin	PRKCE protein results in decreased susceptibility to Curcumin	14742295
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Buthionine Sulfoximine results in increased expression of PRKCE protein]	11118818
D003513	Cycloheximide	Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]	11118818
C004742	daidzein	daidzein affects the localization of and results in increased activity of PRKCE protein	16972265
D003840	Deoxycholic Acid	Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PRKCE protein]	17644113
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased cleavage of PRKCE protein	17644113
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PRKCE mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PRKCE mRNA	21266533
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in decreased expression of PRKCE mRNA]	27392435
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in decreased expression of PRKCE mRNA]	27392435
D004041	Dietary Fats	Dietary Fats results in increased expression of PRKCE mRNA	25016146
D004041	Dietary Fats	[Streptozocin co-treated with Dietary Fats] results in increased expression of PRKCE mRNA	20665664
D004041	Dietary Fats	[Streptozocin co-treated with Dietary Fats] results in increased expression of PRKCE protein	20665664
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of PRKCE mRNA	26033743
C014476	diethyl maleate	Cycloheximide inhibits the reaction [diethyl maleate results in increased expression of PRKCE protein]	11118818
C014476	diethyl maleate	diethyl maleate results in increased expression of and results in increased activity of PRKCE protein	11118818
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PRKCE mRNA	20360939
D004075	Diglycerides	Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCE protein]	18487437
C007517	diphenyleneiodonium	"diphenyleneiodonium inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of PRKCE protein]"	21420390
D004280	Dobutamine	PRKCE protein affects the susceptibility to Dobutamine	15242976
C063533	dofetilide	dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]	20723002
C063533	dofetilide	dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein]	20723002
D004317	Doxorubicin	Doxorubicin results in increased oxidation of PRKCE protein	28818578
C038345	droloxifene	droloxifene affects the localization of PRKCE protein	9714066
D004391	Dust	Dust results in increased activity of PRKCE protein	23281135
D004391	Dust	Vitamin D inhibits the reaction [Dust results in increased activity of PRKCE protein]	23281135
D004837	Epinephrine	PRKCE protein affects the susceptibility to Epinephrine	11454025
D004837	Epinephrine	PRKCE protein affects the susceptibility to Epinephrine	11454025
D000431	Ethanol	Ethanol inhibits the reaction [Streptozocin results in increased expression of PRKCE protein]	12198386
D000431	Ethanol	Ethanol results in decreased expression of PRKCE mRNA	20655511
D000431	Ethanol	PRKCE results in increased susceptibility to Ethanol	20726883
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PRKCE mRNA	12075121\|2909715
D005411	Flame Retardants	Flame Retardants affects the localization of PRKCE protein	15475174
D005557	Formaldehyde	Formaldehyde results in decreased expression of PRKCE mRNA	23416264\|2364984
C069837	fullerene C60	fullerene C60 results in decreased expression of PRKCE mRNA	19167457
D019833	Genistein	Genistein results in increased expression of PRKCE mRNA	12075121
C007845	gingerol	PRKCE protein affects the reaction [gingerol results in increased expression of GDF15 protein]	18058799
D006220	Haloperidol	Haloperidol results in increased expression of PRKCE mRNA	15860345
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in decreased expression of PRKCE protein alternative form	11170310
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in increased expression of PRKCE protein alternative form	11170310\|1124613
C477271	His-Asp-Ala-Pro-Ile-Gly-Tyr-Asp	His-Asp-Ala-Pro-Ile-Gly-Tyr-Asp binds to and results in increased activity of PRKCE protein	15621379
C477271	His-Asp-Ala-Pro-Ile-Gly-Tyr-Asp	His-Asp-Ala-Pro-Ile-Gly-Tyr-Asp results in increased activity of PRKCE protein	20457222
D006861	Hydrogen Peroxide	Hydrogen Peroxide inhibits the reaction [Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]]	17087917
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased activity of PRKCE protein	17087917
D007213	Indomethacin	Indomethacin results in increased expression of PRKCE protein	10702201
D007295	Inositol Phosphates	PRKCE protein promotes the reaction [NTS protein results in increased chemical synthesis of Inositol Phosphates]	18313772
D007444	Inulin	PRKCE protein affects the reaction [EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]]	17991733
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRKCE mRNA	25613284
D007545	Isoproterenol	1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]	20723002
D007545	Isoproterenol	1-(methanesulfonamido-1-naphthyloxy)-2-(N-(4-methane sulfonamidophenethyl)-N-acetamido)ethane inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein]	20723002
D007545	Isoproterenol	2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKCE protein]	16716347
D007545	Isoproterenol	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]	20307649
D007545	Isoproterenol	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein]	20307649
D007545	Isoproterenol	CPU0213 inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein modified form]	20307649
D007545	Isoproterenol	dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]	20723002
D007545	Isoproterenol	dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein]	20723002
D007545	Isoproterenol	Isoproterenol results in increased expression of PRKCE mRNA	12775975\|2030764
D007545	Isoproterenol	Isoproterenol results in increased expression of PRKCE protein	12775975\|2030764
D007545	Isoproterenol	Isoproterenol results in increased expression of PRKCE protein modified form	20307649
D007545	Isoproterenol	Isoproterenol results in increased phosphorylation of PRKCE protein	16716347
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in decreased expression of PRKCE mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in decreased expression of PRKCE mRNA]	27392435
D007657	Ketone Bodies	Ketone Bodies results in decreased expression of PRKCE mRNA	15469884
D007854	Lead	Lead affects the expression of PRKCE mRNA	28903495
D007854	Lead	Lead results in decreased expression of PRKCE protein	16547843
D007854	Lead	Lead results in increased activity of PRKCE protein	10693946
C008261	lead acetate	lead acetate results in decreased expression of PRKCE protein	16547843
D008070	Lipopolysaccharides	Lipopolysaccharides affects the localization of and results in increased activity of PRKCE protein	16330529
D008070	Lipopolysaccharides	PRKCE protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]	16330529
D008094	Lithium	Lithium inhibits the reaction [Methamphetamine results in increased expression of PRKCE mRNA]	19149911
D008244	Lysophosphatidylcholines	PRKCE affects the reaction [Lysophosphatidylcholines results in increased phosphorylation of GJA1 protein]	23973256
D008694	Methamphetamine	Lithium inhibits the reaction [Methamphetamine results in increased expression of PRKCE mRNA]	19149911
D008694	Methamphetamine	Methamphetamine results in increased expression of PRKCE mRNA	19149911
D008727	Methotrexate	Methotrexate affects the expression of PRKCE mRNA	18502557
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of PRKCE mRNA	23649840
C008548	morin	morin results in decreased expression of PRKCE mRNA	28689916
C030517	myxothiazol	myxothiazol inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]	17087917
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PRKCE mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PRKCE mRNA"	25554681
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of PRKCE mRNA	19812364
C438686	N''-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine	"N''-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine results in increased expression of PRKCE mRNA"	15588621
C438686	N''-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine	"N''-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine results in increased expression of PRKCE protein"	15588621
C028007	nickel monoxide	nickel monoxide results in decreased expression of PRKCE mRNA	19167457
D009538	Nicotine	Nicotine results in increased expression of PRKCE mRNA	20426880
C012655	nimesulide	nimesulide inhibits the reaction [F2 protein affects the localization of PRKCE protein]	21811393
C012655	nimesulide	nimesulide inhibits the reaction [KNG1 protein affects the localization of PRKCE protein]	21811393
D009638	Norepinephrine	PRKCE protein promotes the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]	19168439
C464660	obeticholic acid	obeticholic acid results in increased expression of PRKCE mRNA	27939613
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in increased expression of PRKCE mRNA	24888373
D010100	Oxygen	GPX1 protein inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]	17087917
D010100	Oxygen	Hydrogen Peroxide inhibits the reaction [Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]]	17087917
D010100	Oxygen	myxothiazol inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]	17087917
D010100	Oxygen	Oxygen deficiency results in increased activity of PRKCE protein	17087917
D010100	Oxygen	PRKCE gene mutant form results in decreased susceptibility to Oxygen deficiency	18638544
D010100	Oxygen	PRKCE protein affects the reaction [Oxygen deficiency results in increased abundance of Calcium]	17087917
D010100	Oxygen	Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]	17087917
D017239	Paclitaxel	PRKCE protein affects the susceptibility to Paclitaxel	11738263
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PRKCE mRNA"	25510870
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of PRKCE mRNA	18593933
C073402	PD 123319	PD 123319 results in increased expression of PRKCE protein	11893553
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether affects the localization of PRKCE protein	15475174
D015232	Dinoprostone	PRKCE protein affects the susceptibility to Dinoprostone	18509033
D010634	Phenobarbital	Phenobarbital results in decreased methylation of PRKCE gene	19233941
D010656	Phenylephrine	DGKE protein inhibits the reaction [Phenylephrine results in increased localization of PRKCE protein]	18487437
D010656	Phenylephrine	Diglycerides affects the reaction [Phenylephrine results in increased localization of PRKCE protein]	18487437
D010656	Phenylephrine	Phenylephrine affects the localization of PRKCE protein	12003851
D010656	Phenylephrine	Phenylephrine results in increased localization of PRKCE protein	18487437
D010656	Phenylephrine	[chelerythrine results in decreased activity of PRKCE protein] which results in decreased susceptibility to Phenylephrine	12700091
D010656	Phenylephrine	GLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein]	16809552
D010656	Phenylephrine	Phenylephrine affects the localization of PRKCE protein	12720544
D010656	Phenylephrine	Phenylephrine results in increased expression of PRKCE protein	12720544
D010656	Phenylephrine	Phenylephrine results in increased phosphorylation of and results in increased activity of PRKCE protein	16809552
D015240	Phorbol 12,13-Dibutyrate	"Phorbol 12,13-Dibutyrate binds to PRKCE protein"	8106444
D010703	Phorbol Esters	Phorbol Esters affects the localization of and results in increased activity of PRKCE protein	14679204
D010852	Picrotoxin	Picrotoxin results in decreased expression of PRKCE mRNA	15170462
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRKCE mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of PRKCE mRNA	19162173
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in increased expression of PRKCE mRNA	24888373
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of PRKCE mRNA	22714537
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of PRKCE mRNA	19162173
D011374	Progesterone	PRKCE protein promotes the reaction [Dinoprost inhibits the reaction [LHB protein results in increased secretion of Progesterone]]	17760987
D011374	Progesterone	PRKCE protein promotes the reaction [[Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of STAR protein] which results in increased abundance of Progesterone]	21047949
D011374	Progesterone	Progesterone results in decreased expression of PRKCE mRNA	17170212
C045950	propiconazole	propiconazole results in decreased expression of PRKCE mRNA	21278054
D015237	Dinoprost	PRKCE protein promotes the reaction [Dinoprost inhibits the reaction [LHB protein results in increased secretion of Progesterone]]	17760987
C527556	Pt(O,O'-acac)(gamma-acac)(DMS)	"diphenyleneiodonium inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of PRKCE protein]"	21420390
C527556	Pt(O,O'-acac)(gamma-acac)(DMS)	"Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of and results in increased activity of PRKCE protein"	21420390
C527556	Pt(O,O'-acac)(gamma-acac)(DMS)	"[Pt(O,O'-acac)(gamma-acac)(DMS) results in increased abundance of Reactive Oxygen Species] which results in increased activity of PRKCE protein"	21420390
C527556	Pt(O,O'-acac)(gamma-acac)(DMS)	"[Pt(O,O'-acac)(gamma-acac)(DMS) results in increased activity of PRKCE protein] which affects the localization of RELA protein"	21420390
C527556	Pt(O,O'-acac)(gamma-acac)(DMS)	"[Pt(O,O'-acac)(gamma-acac)(DMS) results in increased activity of PRKCE protein] which results in decreased expression of BCL2 protein"	21420390
C527556	Pt(O,O'-acac)(gamma-acac)(DMS)	"[Pt(O,O'-acac)(gamma-acac)(DMS) results in increased activity of PRKCE protein] which results in increased expression of BAX protein"	21420390
C527556	Pt(O,O'-acac)(gamma-acac)(DMS)	"[Pt(O,O'-acac)(gamma-acac)(DMS) results in increased activity of PRKCE protein] which results in increased phosphorylation of MAPK1 protein"	21420390
C527556	Pt(O,O'-acac)(gamma-acac)(DMS)	"[Pt(O,O'-acac)(gamma-acac)(DMS) results in increased activity of PRKCE protein] which results in increased phosphorylation of MAPK3 protein"	21420390
C034912	puag-haad	bisindolylmaleimide I inhibits the reaction [puag-haad results in increased expression of PRKCE mRNA]	28780155
C034912	puag-haad	puag-haad results in increased expression of PRKCE mRNA	28780155
D011794	Quercetin	Quercetin results in decreased expression of PRKCE mRNA	26076811
D017382	Reactive Oxygen Species	"[Pt(O,O'-acac)(gamma-acac)(DMS) results in increased abundance of Reactive Oxygen Species] which results in increased activity of PRKCE protein"	21420390
D017382	Reactive Oxygen Species	PRKCE protein affects the reaction [Reactive Oxygen Species affects the phosphorylation of SHC1 protein]	19168439
C052785	rebamipide	rebamipide results in increased expression of PRKCE mRNA	15104358
D012402	Rotenone	Hydrogen Peroxide inhibits the reaction [Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]]	17087917
D012402	Rotenone	Rotenone inhibits the reaction [Oxygen deficiency results in increased activity of PRKCE protein]	17087917
C032710	rubidium chloride	PRKCE protein affects the reaction [tert-Butylhydroperoxide results in decreased uptake of rubidium chloride]	14570699
C002979	selenomethylselenocysteine	selenomethylselenocysteine results in decreased expression of PRKCE protein	10656618
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of PRKCE mRNA	25895662
C009277	sodium arsenate	sodium arsenate results in increased expression of PRKCE mRNA	21795629
D013311	Streptozocin	arjunolic acid inhibits the reaction [Streptozocin results in increased expression of PRKCE protein]	19682444
D013311	Streptozocin	Ethanol inhibits the reaction [Streptozocin results in increased expression of PRKCE protein]	12198386
D013311	Streptozocin	[Streptozocin co-treated with Dietary Fats] results in increased expression of PRKCE mRNA	20665664
D013311	Streptozocin	[Streptozocin co-treated with Dietary Fats] results in increased expression of PRKCE protein	20665664
D013311	Streptozocin	Streptozocin results in increased expression of PRKCE protein	12198386\|1968244
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of PRKCE mRNA	16214533
D013629	Tamoxifen	Tamoxifen affects the localization of PRKCE protein	9714066
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which affects the localization of PRKCE protein	15761253
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased localization of PRKCE protein	17222441
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate affects the localization of PRKCE protein	23285216
D013755	Tetradecanoylphorbol Acetate	PRKCE protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA]	21705328
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate affects the localization of PRKCE protein	14975926\|2170532
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of PRKCE protein	18313772
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of and results in increased localization of PRKCE protein	16793902
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of PRKCE protein	14975926
D013755	Tetradecanoylphorbol Acetate	bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [PRKCE protein binds to STAT3 protein]]	24496235
D013755	Tetradecanoylphorbol Acetate	PRKCE protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of RAF1 protein]	14623285
D013755	Tetradecanoylphorbol Acetate	PRKCE protein promotes the reaction [[Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of STAR protein] which results in increased abundance of Progesterone]	21047949
D013755	Tetradecanoylphorbol Acetate	PRKCE protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR mRNA]	21047949
D013755	Tetradecanoylphorbol Acetate	SOD2 protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PRKCE protein]	11507057
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate affects the localization of PRKCE protein	12003851
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [PRKCE protein binds to STAT3 protein]	24496235
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of and results in increased localization of PRKCE protein	16099101
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased activity of PRKCE protein	11507057
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of and results in increased phosphorylation of PRKCE protein	21047949
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRKCE mRNA	25613284
D013755	Tetradecanoylphorbol Acetate	PRKCE protein affects the reaction [Tetradecanoylphorbol Acetate results in decreased expression of VEGFA mRNA]	12590138
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate affects the localization of and results in increased activity of PRKCE protein	12590138
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in decreased expression of PRKCE protein	12590138
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate results in decreased expression of VEGFA mRNA] which results in decreased expression of PRKCE protein	12590138
D013755	Tetradecanoylphorbol Acetate	PRKCE protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of SHC1 protein alternative form]	19168439
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate affects the localization of PRKCE protein	19168439
D013853	Thioacetamide	Thioacetamide results in decreased expression of PRKCE mRNA	23411599
D013893	Thiram	Thiram results in decreased activity of PRKCE protein	15998240
D014212	Tretinoin	Tretinoin results in increased expression of PRKCE mRNA	23724009
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCE mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of PRKCE mRNA	24935251\|2627250
C057693	troglitazone	troglitazone results in decreased expression of PRKCE mRNA	19140230
D014415	Tunicamycin	Tunicamycin results in increased expression of PRKCE mRNA	17127020
D014520	Urethane	Urethane results in increased expression of PRKCE mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKCE mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of PRKCE mRNA	26272509
D014635	Valproic Acid	Valproic Acid inhibits the reaction [TAC1 protein results in increased phosphorylation of and results in increased activity of PRKCE protein]	12807426
C066075	vanadium pentoxide	vanadium pentoxide affects the expression of PRKCE mRNA	26210822
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of PRKCE gene	25560391
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride results in increased expression of PRKCE mRNA	25423262
C025643	vinclozolin	vinclozolin affects the expression of PRKCE mRNA	19015723
D014750	Vincristine	PRKCE protein results in increased susceptibility to Vincristine	12809704
C029297	vinylidene chloride	vinylidene chloride results in increased expression of PRKCE protein	14565772
D014807	Vitamin D	Vitamin D inhibits the reaction [Dust results in increased activity of PRKCE protein]	23281135
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of PRKCE mRNA	18593933

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003785	actin monomer binding	-	ISS	-
GO:0004674	protein serine/threonine kinase activity	-	IBA	21873635
GO:0004674	protein serine/threonine kinase activity	-	IDA	15695813
GO:0004697	protein kinase C activity	-	IDA	18556656
GO:0004697	protein kinase C activity	-	TAS	-
GO:0004699	calcium-independent protein kinase C activity	-	IEA	-
GO:0005515	protein binding	-	IPI	16810323 19662078 20353823 22939624 24996056
GO:0005524	ATP binding	-	IEA	-
GO:0008047	enzyme activator activity	-	IMP	18556656
GO:0019899	enzyme binding	-	IDA	18556656
GO:0019899	enzyme binding	-	IPI	15632189
GO:0030546	receptor activator activity	-	IEA	-
GO:0035276	ethanol binding	-	IEA	-
GO:0046872	metal ion binding	-	IEA	-
GO:0071889	14-3-3 protein binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002281	macrophage activation involved in immune response	-	IEA	-
GO:0006468	protein phosphorylation	-	IDA	18556656
GO:0006915	apoptotic process	-	TAS	10438519
GO:0007049	cell cycle	-	IEA	-
GO:0007155	cell adhesion	-	IEA	-
GO:0007165	signal transduction	-	TAS	1382605
GO:0010634	positive regulation of epithelial cell migration	-	IMP	17603037
GO:0010763	positive regulation of fibroblast migration	-	ISS	-
GO:0010811	positive regulation of cell-substrate adhesion	-	IEA	-
GO:0018105	peptidyl-serine phosphorylation	-	IBA	21873635
GO:0018105	peptidyl-serine phosphorylation	-	IDA	15695813
GO:0030168	platelet activation	-	TAS	-
GO:0030838	positive regulation of actin filament polymerization	-	ISS	-
GO:0031397	negative regulation of protein ubiquitination	-	IEA	-
GO:0031663	lipopolysaccharide-mediated signaling pathway	-	ISS	-
GO:0032024	positive regulation of insulin secretion	-	IEA	-
GO:0032230	positive regulation of synaptic transmission, GABAergic	-	IEA	-
GO:0032467	positive regulation of cytokinesis	-	IMP	18604201
GO:0035556	intracellular signal transduction	-	IBA	21873635
GO:0035641	locomotory exploration behavior	-	IEA	-
GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway	-	ISS	-
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	-	TAS	-
GO:0043085	positive regulation of catalytic activity	-	IEA	-
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	-	IEA	-
GO:0043278	response to morphine	-	IEA	-
GO:0043410	positive regulation of MAPK cascade	-	IEA	-
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0050996	positive regulation of lipid catabolic process	-	IEA	-
GO:0051209	release of sequestered calcium ion into cytosol	-	IEA	-
GO:0051279	regulation of release of sequestered calcium ion into cytosol	-	IEA	-
GO:0051301	cell division	-	IEA	-
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	-	IEA	-
GO:0070257	positive regulation of mucus secretion	-	IEA	-
GO:0071361	cellular response to ethanol	-	IEA	-
GO:0071380	cellular response to prostaglandin E stimulus	-	IEA	-
GO:0071456	cellular response to hypoxia	-	IEA	-
GO:0090303	positive regulation of wound healing	-	IMP	17603037
GO:1903078	positive regulation of protein localization to plasma membrane	-	TAS	22732145
GO:2000273	positive regulation of signaling receptor activity	-	IEA	-
GO:2000650	negative regulation of sodium ion transmembrane transporter activity	-	TAS	19193863
GO:2001031	positive regulation of cellular glucuronidation	-	IMP	18556656

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	-	IDA	15632189
GO:0005739	mitochondrion	-	IEA	-
GO:0005783	endoplasmic reticulum	-	IDA	18556656
GO:0005794	Golgi apparatus	colocalizes_with	ISS	-
GO:0005829	cytosol	-	IDA	17603037
GO:0005829	cytosol	-	TAS	-
GO:0005856	cytoskeleton	-	IEA	-
GO:0005886	plasma membrane	-	IDA	15632189 17603037
GO:0005886	plasma membrane	-	TAS	-
GO:0048471	perinuclear region of cytoplasm	-	ISS	-
GO:0071944	cell periphery	-	ISS	-

KEGG ID	KEGG Term
hsa04270	Vascular smooth muscle contraction
hsa04530	Tight junction
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04930	Type II diabetes mellitus

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114508	Effects of PIP2 hydrolysis	TAS
R-HSA-1227986	Signaling by ERBB2	TAS
R-HSA-1250196	SHC1 events in ERBB2 signaling	TAS
R-HSA-1489509	DAG and IP3 signaling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	TAS
R-HSA-2029485	Role of phospholipids in phagocytosis	TAS
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-418597	G alpha (z) signalling events	IEA
R-HSA-76002	Platelet activation, signaling and aggregation	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26384852	Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry. (2015 Nov)	Levran O	CNS Neurosci Ther