Gene: FMN2

56776
-
formin 2
protein-coding
1q43
Ensembl:ENSG00000155816 MIM:606373 Vega:OTTHUMG00000039883 UniprotKB:Q9NZ56
NG_042054.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.461e-2 (AD)  3.520e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10926254chr1:240435799 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10802867chr1:240401213 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LSAMP0.901
DAAM10.885
ADCY20.885
CDH20.875
TRAK10.871
ABI10.868
TMEM1920.866
GPM6A0.862
FAM168A0.862
ITSN10.861

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.666
OR4F29-0.607
FCRL1-0.413
SH2D1A-0.392
CD3G-0.388
CETP-0.378
GADL1-0.373
TFPI2-0.359
FCRL3-0.358
LY9-0.357

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FMN2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FMN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FMN2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FMN2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FMN2 gene27153756
D001151ArsenicArsenic affects the methylation of FMN2 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of FMN2 mRNA20458559
D001280AtrazineAtrazine results in increased expression of FMN2 mRNA25929836
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of FMN2 mRNA26377693
C006780bisphenol Abisphenol A results in decreased expression of FMN2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of FMN2 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FMN2 mRNA23741332
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of FMN2 mRNA]16221973
D007631ChlordeconeFMN2 gene SNP affects the susceptibility to Chlordecone25622337
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FMN2 gene20938992
D016572CyclosporineCyclosporine results in decreased expression of FMN2 mRNA20106945
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of FMN2 mRNA16963248
C014347decitabinedecitabine inhibits the reaction [Smoke results in decreased expression of FMN2 mRNA]21095227
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of FMN2 mRNA28962523
D002945CisplatinCisplatin promotes the reaction [jinfukang results in decreased expression of FMN2 mRNA]27392435
D002945CisplatinCisplatin results in decreased expression of FMN2 mRNA27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in decreased expression of FMN2 mRNA]27392435
D004041Dietary FatsDietary Fats results in decreased expression of FMN2 mRNA25016146
D000431EthanolEthanol results in decreased expression of FMN2 mRNA19167417
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FMN2 mRNA17942748
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of FMN2 mRNA27776689
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FMN2 gene20938992
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of FMN2 mRNA16963248
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of FMN2 mRNA22634610
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of FMN2 mRNA16963248
C544151jinfukangCisplatin promotes the reaction [jinfukang results in decreased expression of FMN2 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in decreased expression of FMN2 mRNA]27392435
C544151jinfukangjinfukang results in decreased expression of FMN2 mRNA27392435
D018021Lithium ChlorideLithium Chloride results in decreased expression of FMN2 mRNA23527032
D008558MelphalanMelphalan results in decreased expression of FMN2 mRNA22363485
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FMN2 gene20938992
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of FMN2 mRNA26705709
D010634PhenobarbitalPhenobarbital results in increased expression of FMN2 mRNA23091169
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of FMN2 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of FMN2 mRNA19690047
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FMN2 mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FMN2 mRNA25895662
D012906Smokedecitabine inhibits the reaction [Smoke results in decreased expression of FMN2 mRNA]21095227
D018038Sodium SeleniteSodium Selenite results in increased expression of FMN2 mRNA24383545
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FMN2 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FMN2 mRNA17942748
D014112ToxapheneFMN2 gene SNP affects the susceptibility to Toxaphene25622337
D014212TretinoinTretinoin results in increased expression of FMN2 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FMN2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of FMN2 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of FMN2 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of FMN2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FMN2 mRNA24935251|2800136
D014635Valproic AcidValproic Acid affects the expression of FMN2 mRNA17963808
D014638VanadatesVanadates results in decreased expression of FMN2 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FMN2 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FMN2 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of FMN2 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0003779actin binding-IDA20082305  
GO ID GO Term Qualifier Evidence PubMed
GO:0006974cellular response to DNA damage stimulus-IMP23375502  
GO:0007275multicellular organism development-IEA-  
GO:0015031protein transport-IEA-  
GO:0016192vesicle-mediated transport-ISS-  
GO:0035556intracellular signal transduction-IEA-  
GO:0040038polar body extrusion after meiotic divisions-ISS-  
GO:0042177negative regulation of protein catabolic process-IMP23375502  
GO:0043066negative regulation of apoptotic process-IMP23375502  
GO:0046907intracellular transport-ISS-  
GO:0048477oogenesis-ISS-  
GO:0051295establishment of meiotic spindle localization-ISS-  
GO:0051758homologous chromosome movement towards spindle pole involved in homologous chromosome segregation-ISS-  
GO:0070649formin-nucleated actin cable assembly-ISS-  
GO:0071456cellular response to hypoxia-IMP23375502  
GO ID GO Term Qualifier Evidence PubMed
GO:0005730nucleolus-IDA23375502  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005819spindle-IEA-  
GO:0005829cytosol-IDA20082305  
GO:0005886plasma membrane-IEA-  
GO:0005902microvillus-IEA-  
GO:0005938cell cortex-ISS-  
GO:0015629actin cytoskeletoncolocalizes_withIDA20082305  
GO:0030659cytoplasmic vesicle membrane-ISS-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04320Dorso-ventral axis formation
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal