Gene: FSTL5

56884
-
follistatin like 5
protein-coding
4q32.2
Ensembl:ENSG00000168843 Vega:OTTHUMG00000161397 UniprotKB:Q8N475
NC_000004.12
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.561e-1 (AD)  7.793e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17536732chr4:161903214 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs115460205chr4:161890417 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs1440588chr4:161842862 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB3C0.925
ROBO20.921
GRIP10.908
PGM2L10.907
PEG30.902
GLRA20.901
KRT2220.899
HMGCLL10.898
PAK30.898
TUSC30.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.62
SYDE1-0.583
RNF135-0.556
MAGEA12-0.552
CDA-0.543
REST-0.539
CHST14-0.538
LATS2-0.534
ANPEP-0.532
CNN2-0.531

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of FSTL5 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of FSTL5 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FSTL5 gene27153756
D000393Air PollutantsAir Pollutants analog results in increased expression of FSTL5 mRNA21757418
C006632arsenic trioxidearsenic trioxide results in decreased expression of FSTL5 mRNA26705709
D001280AtrazineAtrazine results in increased expression of FSTL5 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FSTL5 mRNA22316170
C044887beta-methylcholinebeta-methylcholine affects the expression of FSTL5 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of FSTL5 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of FSTL5 gene28505145
D002104CadmiumCadmium results in decreased expression of FSTL5 mRNA24376830
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FSTL5 mRNA29097150
D004397FonofosFonofos results in increased methylation of FSTL5 promoter22847954
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of FSTL5 mRNA17183730
D008727MethotrexateMethotrexate results in increased expression of FSTL5 mRNA24449571
D010100OxygenOxygen deficiency results in decreased expression of FSTL5 mRNA26516004
D010278ParathionParathion results in increased methylation of FSTL5 promoter22847954
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FSTL5 mRNA25895662
D013501Surface-Active AgentsSurface-Active Agents results in increased expression of FSTL5 mRNA22467014
C012568terbufosterbufos results in increased methylation of FSTL5 promoter22847954
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of FSTL5 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of FSTL5 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FSTL5 gene25560391
D015034Zinc OxideZinc Oxide analog results in decreased expression of FSTL5 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI24407287  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal