Gene: TRPC7

57113
TRP7
transient receptor potential cation channel subfamily C member 7
protein-coding
5q31.1
Ensembl:ENSG00000069018 Vega:OTTHUMG00000189265 UniprotKB:Q9HCX4
NC_000005.10
PubMed|SNP Mapped
7   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.691e-1 (AD)  8.684e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2673931chr5:136353748 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs2546657chr5:136348047 (GRCh38.p7)T>Anicotine dependenceSNV(Single Nucleotide Variation)
rs4976489chr5:136343269 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs1499764chr5:136328500 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs2216640chr5:136319413 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)
rs10070699chr5:136316252 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)
rs4976485chr5:136314610 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18513357chr5:135696688TRPC7Gene body1.491e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRNA30.765
LHX80.743
DGKK0.738
DDC0.728
SLC18A30.725
COCH0.717
SLC35D30.714
GPR1010.711
GPR10.708
ANKRD34B0.704

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TNNT2-0.339
SLC17A7-0.324
SOHLH1-0.316
SYTL2-0.307
TBR1-0.302
MYBPHL-0.276
SLC6A12-0.273
NEUROD2-0.272
SLC38A11-0.269
EMX1-0.258

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0382371-oleoyl-2-acetylglycerol1-oleoyl-2-acetylglycerol results in increased activity of TRPC7 protein22031853
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TRPC7 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TRPC7 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TRPC7 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TRPC7 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TRPC7 mRNA"25510870
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TRPC7 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TRPC7 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of TRPC7 mRNA21298039
D006710HomocysteineHomocysteine results in decreased expression of TRPC7 mRNA17326132
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TRPC7 mRNA24449571
C006780bisphenol Abisphenol A results in decreased expression of TRPC7 mRNA25181051
D002118CalciumTRPC1 protein inhibits the reaction [TRPC7 protein results in increased transport of Calcium]22157757
D002118CalciumTRPC7 protein results in increased transport of Calcium22157757
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TRPC7 mRNA22129741
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of TRPC7 mRNA22129741
C063855microcystin RRmicrocystin RR results in increased expression of TRPC7 protein19111056
C070571ML 7ML 7 results in increased activity of TRPC7 protein17603544
C056218ML 9ML 9 results in increased activity of TRPC7 protein17603544
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of TRPC7 mRNA"25510870
D015232DinoprostoneTRPC7 results in increased susceptibility to Dinoprostone16790996
C006253pirinixic acidpirinixic acid results in increased expression of TRPC7 mRNA20813756
D011441PropylthiouracilPropylthiouracil results in increased expression of TRPC7 mRNA24780913

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005262calcium channel activity-TAS-  
GO:0005515protein binding-IPI21402151  
GO:0015279store-operated calcium channel activity-IBA21873635  
GO:0070679inositol 1,4,5 trisphosphate binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006828manganese ion transport-IBA21873635  
GO:0007338single fertilization-IBA21873635  
GO:0030168platelet activation-TAS-  
GO:0051480regulation of cytosolic calcium ion concentration-IBA21873635  
GO:0070588calcium ion transmembrane transport-IBA21873635  
GO:0070588calcium ion transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IEA-  
GO:0005801cis-Golgi network-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114508Effects of PIP2 hydrolysisTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-139853Elevation of cytosolic Ca2+ levelsTAS
R-HSA-162582Signal TransductionTAS
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373752Netrin-1 signalingIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418360Platelet calcium homeostasisTAS
R-HSA-418890Role of second messengers in netrin-1 signalingIEA
R-HSA-422475Axon guidanceIEA
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27613936High Prevalence of Smoking in the Roma Population Seems to Have No Genetic Background. (2016 Dec)Fiatal SNicotine Tob Res