Gene: ADCK1

57143
-
aarF domain containing kinase 1
protein-coding
14q24.3
Ensembl:ENSG00000063761 Vega:OTTHUMG00000171520 UniprotKB:Q86TW2
NC_000014.9
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.950e-2 (AD)  6.720e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17106558chr14:77897589 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17753195chr14:77885419 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SARS20.899
NACAD0.889
HID10.885
RPS6KL10.882
BRF10.877
ENDOV0.875
RNF1120.874
FAAH0.872
PRMT70.87
SLC27A40.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC2B-0.502
WWTR1-0.478
ARHGAP42-0.478
EVC2-0.47
PABPC4L-0.467
NEDD4-0.465
MAML2-0.459
CST7-0.457
NMI-0.455
GIMAP2-0.455

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ADCK1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ADCK1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ADCK1 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of ADCK1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ADCK1 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ADCK1 mRNA21298039
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ADCK1 mRNA20044591
C028007nickel monoxidenickel monoxide results in increased expression of ADCK1 mRNA19167457
D011374ProgesteroneProgesterone results in increased expression of ADCK1 mRNA19690047
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ADCK1 mRNA21570461
D014635Valproic AcidValproic Acid results in decreased expression of ADCK1 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of ADCK1 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006468protein phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal